Klippel-Trenaunay Syndrome

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What is Klippel-Trenaunay syndrome?

Klippel-Trenaunay syndrome (KTS) is a condition that affects the development of blood vessels, soft tissues (such as skin and muscles), and bones. The disorder has three characteristic features:

  • A red birthmark called a "port-wine stain"
  • Abnormally overgrown, soft tissues and bones, usually in one leg but sometimes in the arms or (rarely) on the torso
  • Vein malformations (deformities)
Learn About Clinical Trials
Clinical trials are studies that allow us to learn more about disorders and improve care. They can help connect patients with new and upcoming treatment options.

How can I or my loved one help improve care for people with Klippel-Trenaunay syndrome?

Consider participating in a clinical trial so clinicians and scientists can learn more about KTS and related disorders. Clinical research uses human volunteers to help researchers learn more about a disorder and perhaps find better ways to safely detect, treat, or prevent disease.

All types of volunteers are needed—those who are healthy or may have an illness or disease—of all different ages, sexes, races, and ethnicities to ensure that study results apply to as many people as possible, and that treatments will be safe and effective for everyone who will use them.

For information about participating in clinical research visit NIH Clinical Research Trials and You. Learn about clinical trials currently looking for people with KTS at Clinicaltrials.gov.

Where can I find more information about Klippel-Trenaunay syndrome?

The following resource may provide more information:


Order publications from the NINDS Catalog
The NINDS Publication Catalog offers printed materials on neurological disorders for patients, health professionals, and the general public. All materials are free of charge, and a downloadable PDF version is also available for most publications.