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Notice Intent Publish Revised Funding Opportunity Announcement NeuroNEXT Clinical Trials U01) Notice Number: NOT-NS-13-036 Update: following update relating this announcement been issued: August 30, 2013 - Issuance PAR-13-343 NeuroNEXT Clinical Trials U01). Key Dates Release Date: July 16, 2013 Estimated Publication Date Announcement: September, 2013  First Estimated Application Due Date: December 2, 2013 Earliest Estimated Award Date: June, 2014 Earliest Estimated Start Date: July, 2014 Related Announcements PAR-11-343 NOT-NS-13-034 Issued National Institute Neurological Disorders Stroke NINDS) Purpose NINDS intends reissue PAR-11-343 solicit applications NeuroNEXT Clinical Trials U01). revised Funding Opportunity Announcement FOA) expected be published Fall 2013 an expected initial application due date December 2013. FOA utilize U01 activity code. Details the planned FOA provided below. Research Initiative Details Notice encourages investigators begin consider applying this revised FOA. revised FOA encourage applications biomarker validation trials exploratory clinical trials drugs, biologics, surgical therapies devices may contribute the justification and provide data required design subsequent trial further evaluate intervention. Applications drugs biologics should provide compelling scientific evidence the investigational agent proposed study reach/act upon designated target that mechanism action such it be benefit ameliorating specific aspect the disease. Applications devices propose early traditional feasibility studies. Diseases chosen study should based the NINDS' strategic plan clinical research interests.  APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: D. Elizabeth McNeil, MD MSc National Institute Neurological Disorders & Stroke Telephone: 301-496-9135 Email: mcneilde@ninds.nih.gov  

Notice Intent Publish Funding Opportunity Announcement the NINDS Morris K. Udall Centers Excellence Parkinson's Disease Research P50) Notice Number: NOT-NS-13-033 Key Dates Release Date: July 11, 2013 Estimated Publication Date Announcement: November, 2013  First Estimated Application Due Date: January, 2014  Earliest Estimated Award Date: July, 2014  Earliest Estimated Start Date: July, 2014  Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS) continue Morris K. Udall Centers Excellence Parkinson's Disease Research program publishing Funding Opportunity Announcement FOA) new renewal applications. purpose this Notice to alert potential applicants to provide lead time the development responsive projects.  FOA utilize Specialized Center P50) activity code, will support spectrum basic, translational clinical research activities utilizing integrated, multidisciplinary approach a specific disease entity, Parkinson's Disease PD).   is anticipated this FOA be published autumn 2013 an expected application due date early winter 2014. Research Initiative Details NINDS intends solicit new renewal applications the Morris K. Udall Centers Excellence Parkinson’s Disease Research program, consortium specialized Centers work collaboratively well independently define causes and discover improved treatments this disease. Individual Centers establish unique, interdisciplinary programs optimize available expertise basic, translational clinical research required advance PD research. overall theme, proposed research projects integral cores each Center relate directly the etiology, pathogenesis treatment PD related parkinsonian disorders. considerable degree collaboration among investigators required achieve overarching objectives each Center. proposal must include least translational research project focusing the development therapeutics, diagnostics, clinical criteria will inform new approaches the treatment PD. Notably, Centers Excellence, Udall Centers serve regional national resources PD research. Successful applicants participate the network existing Udall Centers foster translation scientific findings novel treatments PD. Applicants request maximum annual direct costs 1,500,000. Full details be available the FOA. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Beth-Anne Sieber, PhD Program Director, Neurodegeneration Cluster Division Extramural Research National Institute Neurological Disorders Stroke 6001 Executive Boulevard, Room 2223 Bethesda, MD 20892-9525 Telephone: 301) 496-5680 Email: sieberb@ninds.nih.gov

Discontinuation PAR-11-343 NeuroNEXT Clinical Trials U01)" Notice Number: NOT-NS-13-034 Update: following update relating this announcement been issued: July 16, 2013 - Notice NOT-NS-13-036. Notice Intent Publish Revised Funding Opportunity Announcement NeuroNEXT Clinical Trials U01). Key Dates Release Date: July 3, 2013 Related Announcements PAR-11-343 Issued National Institute Neurological Disorders Stroke NINDS) Purpose Notice informs potential applicants NINDS discontinue PAR-11-343 NeuroNEXT Clinical Trials U01). Applications not accepted NINDS this Funding Opportunity Announcement after August 3, 2013. Inquiries Please direct inquiries to: D. Elizabeth McNeil, MD, MSc National Institute Neurological Disorders Stroke Office Clinical Trials 6001 Executive Blvd, Room 2114 Bethesda, MD 20892 Telephone: 301) 496-4135 Email: mcneilde@ninds.nih.gov  

Notice Change Earliest Start Date Applications Submitted RFA-DA-14-002 Short-term Mentored Career Enhancement Awards the Basic Behavioral Social Sciences: Cross-Training the Intersection Animal Models Human Investigation K18)" Notice Number: NOT-DA-13-040 Key Dates Release Date: June 24, 2013 Related Announcements RFA-DA-14-002 Issued NIH Basic Behavioral amp; Social Science Opportunity Network OppNet) behalf its constituent organizations: National Cancer Institute NCI) National Eye Institute NEI) National Heart, Lung, Blood Institute NHLBI) National Human Genome Research Institute NHGRI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Allergy Infectious Diseases NIAID) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Dental Craniofacial Research NIDCR) National Institute Diabetes Digestive Kidney Diseases NIDDK) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute General Medical Sciences NIGMS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) National Institute Minority Health Health Disparities NIMHD) National Library Medicine NLM) Fogarty International Center FIC) National Center Complementary Alternative Medicine NCCAM) National Center Advancing Translational Sciences NCATS) Division Program Coordination, Planning Strategic Initiatives, Office Research Infrastructure Programs ORIP) Office Behavioral Social Sciences Research OBSSR) Office Dietary Supplements ODS) Office Research Women’s Health ORWH) Purpose notice changes start date RFA-DA-14-002 quot;Short-term Mentored Career Enhancement Awards the Basic Behavioral Social Sciences:  Cross-Training the Intersection Animal Models Human Investigation K18)". Currently reads: Earliest Start Date December 2014 Modified read: Earliest Start Date September 2014 other aspects the FOA remain same. Inquiries Please direct inquiries to: Minda Lynch, PhD National Institute Drug Abuse NIDA) Telephone: 301-435-1322 Email: mlynch1@mail.nih.gov Melissa S. Gerald, Ph.D. Division Behavioral Social Research National Institute Aging NIA) Phone: 301-402-4156 Email: melissa.gerald@nih.gov

Notice Intent Publish Funding Opportunity Announcement NINDS Clinical Trial Methodology Course R25) Notice Number: NOT-NS-13-030 Key Dates Release Date: June 14, 2013 Estimated Publication Date Announcement: August 2013 First Estimated Application Due Date: October 2013  Earliest Estimated Award Date: March 2014  Earliest Estimated Start Date: 2014 Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS) intends issue Funding Opportunity Announcement FOA) solicit applications the NINDS Clinical Research Methods Course. goal this initiative to enhance training new investigators the conduct high-quality clinical trials. Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects.  FOA expected be published summer 2013 an expected application due date Fall 2013. FOA utilize R25 activity code. Details the planned FOA provided below. Research Initiative Details NINDS Clinical Research Methods Clinical Neurological Disorders course use R25 grant mechanism support educational course faculty any clinical neuroscience subspecialty introduce to principles good clinical trial design exposing early career clinical scientists the full spectrum challenges clinical research. NINDS aims develop cadre well-trained researchers whose expertise foster better clinical study design thereby lead improved regimens therapy prevention neurological disorders. is anticipated this annual course yield group talented, dedicated clinical neuroscience researchers will consequently in position obtain funding their own high quality clinical research.  the program successful, is anticipated participant scholars return their organizations/institutions where will take prominent role advancing local clinical research priorities neurology.  achieve objective, NINDS requires high-impact program enhancing training future researchers is innovative that exceeds training experiences available those treating neurological disease.  important part the NINDS extramural clinical trials budget spent early phase trials phase 1, 2, pilot trials) that primary focus this grant on training early phase clinical trials. Specific performance goals the FOA are: develop scientific content, curriculum, format a comprehensive, hands-on educational program incorporating innovative methods teaching conducting clinical research taking advantage knowledge gained disciplines outside neurology, emphasis proof principle studies new therapeutic agents, validating biomarkers use early phase clinical trials. organize conduct educational program, including recruitment selection faculty participants.  conduct formal evaluation the program and, where relevant, incorporate results subsequent course offerings. maximize course impact making didactic material available online the additional benefit a wider audience. is expected the grant tasks be performed two phases.  Phase comprises development the education program; Phase II includes conducting iteration the course course evaluation. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Robin Conwit, MD Program Director Office Clinical Research National Institute Neurological Disorders Stroke Telephone: 301) 496-9135 Fax: 301) 410-1080 Email: Robin.Conwit@nih.gov nbsp;

Notice Participation Additional NIH Institutes Centers PAR-13-208 Countermeasures Against Chemical Threats CounterACT) Cooperative Research Projects U01) Notice Number: NOT-NS-13-029 Key Dates Release Date: 14, 2013 Related Announcements PAR-13-208 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to inform potential applicants the participation additional NIH Institutes, effective immediately, Funding Opportunity Announcement FOA) PAR-13-208. following sections PAR-13-208 been updated reflect participation NEI, NIAID, NIAMS, NIEHS this FOA. Part 1. Overview Information Components Participating Organizations National Institute Neurological Disorders Stroke NINDS) National Eye Institute NEI) National Institute Allergy Infectious Diseases NIAID) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) National Institute Environmental Health Sciences NIEHS) National Institute General Medical Sciences NIGMS) Catalog Federal Domestic Assistance CFDA) Number(s) 93.853; 93.867; 93.855; 93.856; 93.846; 93.113; 93.859  Part 2. Section VII. Agency Contacts Scientific/Research Contact(s)       Houman Araj, Ph.D. National Eye Institute NEI) Telephone: 301-451-2020 Email: arajh@nei.nih.gov Gennady E. Platoff Jr., Ph.D. National Institute Allergy amp; Infectious Diseases NIAID) Telephone: 301-451-4418 Email: platoffg@niaid.nih.gov Hung Tseng, Ph.D. National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) Telephone: 301-594-5032 Email: tsengh@mail.nih.gov Srikanth S. Nadadur, Ph.D. National Institute Environmental Health Sciences NIEHS) Telephone: 919-541-5327 Email: nadadurs@niehs.nih.gov Financial/Grants Management Contact(s) William W. Darby Grants Management Branch National Eye Institute NEI) Telephone: 301-451-2020 Email: darbyw@mail.nih.gov Victoria Connors Grants Management Branch National Institute Allergy amp; Infectious Diseases NIAID) Telephone: 301-402-5065 Email: connorssv@niaid.nih.gov Melinda B. Nelson Grants Management Branch National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) Telephone: 301-435-5278 Email: nelson@mail.nih.gov Lisa Archer Edwards, MBA Grants Management Branch National Institute Environmental Health Sciences NIEHS) Telephone: 919-541-0751  Email:  archer@niehs.nih.gov Inquiries Please direct inquiries to: David A. Jett, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-6035  Email: jettd@ninds.nih.gov

Notice Correction the Review Selection Process RFA-NS-13-015 quot;Pilot Projects Sports-Related Brain Spinal Cord Injury R03)" Notice Number: NOT-NS-13-026 Key Dates Release Date:   April 19, 2013 Related Announcements RFA-NS-13-015     Issued National Institute Neurological Disorders Stroke NINDS)) Purpose National Institute Neurological Disorders Stroke NINDS) correcting process the selection grants fund RFA-NS-13-015 quot;Pilot Projects Sports-Related Brain Spinal Cord Injury R03)" include review the NIH Institute's Advisory Council which grant been given primary assignment. CURRENTLY READS: Review Selection Process Following initial peer review, recommended applications receive second level review the National Advisory Neurological Disorders Stroke NANDS) Council. CHANGED READ: Review Selection Process  Following initial peer review, recommended applications receive second level review the NIH Institute's Advisory Council which grant been given primary assignment. other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Ramona Hicks, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1447 Email: hicksra@mail.nih.gov

Notice Correction the Review Selection Process RFA-NS-13-014 quot;Pilot Projects Sports-Related Brain Spinal Cord Injury R21)" Notice Number: NOT-NS-13-025 Key Dates Release Date:  April 19, 2013   Related Announcements RFA-NS-13-014    Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS) correcting process the selection grants fund RFA-NS-13-014 quot;Pilot Projects Sports-Related Brain Spinal Cord Injury R21)" include review the NIH Institute's Advisory Council which grant been given primary assignment. CURRENTLY READS: Review Selection Process Following initial peer review, recommended applications receive second level review the National Advisory Neurological Disorders Stroke NANDS) Council. CHANGED READ: Review Selection Process Following initial peer review, recommended applications receive second level review the NIH Institute's Advisory Council which grant been given primary assignment. other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Ramona Hicks, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1447 Email: hicksra@mail.nih.gov

Notice Clarification Responsive Projects RFA-NS-13-009 quot;High Impact Neuroscience Research Resource Grants R24)" Notice Number: NOT-NS-13-024 Key Dates Release Date: April 12, 2013 Related Announcements RFA-NS-13-009 NOT-MH-12-020 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to clarify project eligibility for RFA-NS-13-009 "High Impact Neuroscience Research Resource Grants R24)".   accordance a recent change funding support repositories brain related bio-specimens NOT-MH-12-020), NINDS not accept applications proposing activities submitted response RFA-NS-13-009 . Inquiries Please direct inquiries to: Edmund Talley, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1917 Email strongly preferred): TalleyE@mail.nih.gov

Notice Extend Expiration Date PAR-10-199 quot;NINDS Exploratory Clinical Trials R01)" Notice Number:  NOT-NS-13-022 Key Dates Release Date: March 25, 2013 Related Announcements PAR-10-199 Issued National Institute Neurological Disorders Stroke NINDS) Purpose NINDS gives notice the extension the expiration date PAR-10-199 quot;NINDS Exploratory Clinical Trials R01)" until September 8, 2013. Current Expiration Date: 8, 2013 New Expiration Date: September 8, 2013 other aspects the FOA remain unchanged. Inquiries Please direct inquiries to: Peter R. Gilbert, Sc.M. National Institute Neurological Disorders Stroke Telephone: 301) 496-0870 Email: Peter.Gilbert@nih.gov