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The Division of Convulsive, Developmental, and Neuromuscular Disorders, National Institute of Neurological Disorders and Stroke (NINDS) encourages the submission of research grant applications related to genetics of the epilepsies. The NINDS solicits submission of research project grants to stimulate research in both basic and clinical aspects of genetics of the epilepsies. The scope of this program encompasses both animal and human studies which would utilize a variety of experimental approaches and methods.

The purpose of this announcement is to facilitate a research area that defines a comparative framework for understanding the neural substrates of behavior, its principles, organization, and disorders. Applicants are encouraged to consider the advantages of using animal species representing different evolutionary levels including species that expand the kinds of animals conventionally used in brain and behavior research, as well as those that may require further development as experimental models.

The National Institute of Neurological Disorders and Stroke (NINDS) invites research grant applications seeking support of a wide spectrum of research directed at generating improved knowledge concerning amyotrophic lateral sclerosis (ALS).

The National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Allergy and Infectious Diseases (NIAID) invite research grant applications seeking support of a wide spectrum of research directed at generating improved knowledge concerning Lyme disease of the nervous system.

The Division of Convulsive, Developmental, and Neuromuscular Disorders, National Institute of Neurological Disorders and Stroke (NINDS) is revising and reissuing an existing NINDS program announcement published January 8, 1988 to notify the scientific community of continuing NINDS interest in research addressing the surgical management of epilepsies.

The Division of Convulsive, Developmental, and Neuromuscular Disorders, National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Mental Health (NIMH) are revising and reissuing a NINDS program announcement on narcolepsy published in the NIH Guide to Grants and Contracts, Vol. 19, No. 15, April 13, 1990, to notify the scientific community of continuing NINDS/NIMH interest in the submission of research project grant applications related to narcolepsy.

The National Institute of Neurological Disorders and Stroke (NINDS), a component of the National Institutes of Health, invites research grant applications seeking support of a wide spectrum of research on multiple sclerosis.

The olfactory nerve provides a direct anatomic conduit between the external chemical environment and the brain. This location puts the olfactory system at risk for damage from environmental toxicants and pathogens. These toxic agents comprise the major health hazard to human olfaction. However, the direct and indirect effects of these agents on the peripheral and central olfactory system are poorly understood. The purpose of this Program Announcement (PA) is to foster investigator-initiated research fundamental to understanding the impact of environmental toxicants and pathogens on the olfactory system. A broad range of studies extending from the molecular to the behavioral areas of basic and clinical research is applicable to this PA. The scope of these areas encompasses the transport of toxic substances into the brain through the olfactory nerve, olfactory mucosal defense mechanisms, neurogenesis, the relation of neurodegenerative diseases, such as Alzheimer"s disease, to olfactory abnormalities induced by toxic agents, and the vulnerability of an aged olfactory system to toxic agents.

The Division of Stroke and Trauma (DST), National Institute of Neurological Disorders and Stroke (NINDS), invites applications for support of research that will increase our knowledge of the mechanisms underlying the neuronal regeneration and plasticity that can follow spinal cord injury.

The Division of Stroke and Trauma (DST), National Institute of Neurological Disorders and Stroke (NINDS), invites applications for support of research that will increase our understanding of the causes of, and add to our ability to treat and prevent, recurrent headache, especially migraine.