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The National Institute of Nursing Research and co-sponsoring Institutes and Centers encourage research proposals in the management of chronic pain across the lifespan. Pain is a subjective experience influenced by gender, age, race/ethnicity and psychosocial factors. The management of pain is influenced by patient, health care provider and system factors. Research is needed to determine the most effective interventions to remove barriers to effective treatment, to determine the most effective pharmacological and non- pharmacological therapies including complementary and alternative therapies, to identify assessment tools for patients unable to verbalize their pain, and to identify effective pain management strategies for individuals with disabilities and underserved populations.

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Eye Institute (NEI), the National Heart, Lung and Blood Institute (NHLBI), the National Institute on Aging (NIA), the National Institute of Neurological Disorders and Stroke (NINDS) and the Office of Dietary Supplements (ODS) seek basic and clinical research applications to study the use of vitamin E and other antioxidants in the prevention or amelioration of diabetic complications.

The National Institute of Neurological Disorders and Stroke (NINDS) is interested in promoting collaborations among junior investigators (Postdoctoral Fellows through Assistant Professors, or equivalent) to stimulate translational research in the field of epilepsy. To this end the NINDS invites exploratory/developmental research grant applications (R21) in patient- oriented research, developmental neurobiology, genetics, advanced technology, imaging, pharmacotherapeutics, or other research areas, which are likely to lead to the cure of epilepsy (defined as "the prevention of epilepsy before it occurs in people at risk, and the cessation of seizures without therapy-associated side effects in those who develop the disease"). Emphasis will be placed on cross- disciplinary collaborations, novel hypotheses, and unique approaches in applying fundamental neurobiological concepts to epilepsy research. Special consideration will be given to proposals that enhance the application of scientific knowledge to the understanding and treatment of the disorder. This initiative requires collaborations of two or more junior investigators at different institutions, or in different laboratories within the same institution. Investigators already working together at the same department are not eligible.

The National Institutes of Health Autism Coordinating Committee (NIH/ACC) is implementing the aspects of the Children"s Health Act of 2000 that relate to support of autism research by NIH. The NIH/ACC is composed of the NIH institutes currently funding autism research: NIMH, NICHD, NINDS, NIDCD, and NIEHS. An important aspect of these activities is the establishment of Centers of Excellence in Autism Research, and in this RFA the participating institutes invite research grant applications for such Centers. These Centers will constitute a cohesive program, operating under an NIH cooperative agreement, which will be called the STAART Centers Program (Studies to Advance Autism Research and Treatment).

This Program Announcement (PA) solicits applications for investigator- initiated research related to the prevention and management of cachexia to improve the quality of life for these patients. Cachexia is a condition of severe malnutrition characterized by anorexia, weight loss and muscle wasting that occurs as a consequence of chronic conditions such as cystic fibrosis, cerebral palsy, cancer, AIDS, congestive heart failure, failure to thrive in older populations, end-stage organ failure, neurological degenerative diseases, chronic obstructive lung disease, chronic liver disease, and chronic renal disease. Cachexia has repeatedly been associated with adverse clinical outcomes, and increased morbidity and mortality. Research findings are reported in the literature which address individual symptoms and speculated causes of cachexia but data are not available to provide a scientific base for a multidisciplinary approach to prevent cachexia and manage the associated symptoms to improve the quality of life for patients suffering from cachexia. The goal of this PA is threefold: 1) to stimulate basic and clinical research in cachexia, 2) to examine cachexia in relation to several related symptoms to improve quality of life, and 3) to examine cachexia symptoms in two or more chronic conditions.

The National Institutes of Neurological Disorders and Stroke (NINDS) will award National Research Service Award (NRSA) Short-Term Institutional Training Grants (T35) to eligible institutions to provide research training opportunities for medical students who are preparing for careers in basic or clinical neurological sciences research. The purpose of this program is to help ensure that a highly trained workforce is available to assume leadership roles related to the Nation"s neurological sciences research agenda. The goals of the program are to encourage the interest of potential clinician scientists early in their education, and accelerate entry to independent research.

The National Institutes of Neurological Disorders and Stroke (NINDS) will award individual fellowships (F31) to eligible individuals to provide research training opportunities for medical students who are preparing for careers in basic or clinical neurological sciences research. The purpose of this program is to help ensure that a highly trained workforce is available to assume leadership roles related to the Nation"s neurological sciences research agenda. The goals of the program are to encourage the interest of potential clinician scientists early in their education, and accelerate entry to independent research.

The National Institute of Neurological Disorders and Stroke (NINDS) invites applications for individual National Research Service Award (NRSA) fellowships for MD/PhD and MD/MPH students. There is a critical need for clinician-scientists with the medical training and research experience to investigate problems of disease in humans. Yet, the enormous complexity of the neurological disorders prevents the standard course of study at most medical schools from providing the experience necessary to develop researchers. Support for NRSA MD/PhD and MD/MPH fellowships is designed to help ensure that highly trained clinician-scientists will be available in adequate numbers to conduct basic and clinical research in disorders relevant to the mission of the NINDS. While this program is primarily focused on individuals pursuing the MD degree, other health professional students (e.g., D.O., D.D.S.) may also apply. For additional information about NINDS programs please consult the following Website: http://www.ninds.nih.gov

The National Institute of Neurological Disorders and Stroke (NINDS), The National Institute on Deafness and Other Communication Disorders (NIDCD), the National Institute of Environmental Health Sciences (NIEHS), the National Institute of Mental Health (NIMH), the Michael J. Fox Foundation for Parkinson"s Research, the Parkinson’s Disease Foundation/National Parkinson’s Foundation, and the Parkinson’s Alliance invite investigator-initiated grant applications to conduct research relevant to the cure, cause, prevention or improved treatment of Parkinson’s Disease (PD) and its complications. The intent of this RFA is to stimulate novel, innovative, or high impact approaches to the field of Parkinson"s Disease research within the framework of the exploratory/developmental granting mechanism to enhance and escalate discoveries beneficial to PD.

The purpose of this Program Announcement (PA) is to solicit applications as part of a National Institutes of Health (NIH) initiative to increase our support of the zebrafish as an animal model for development, organ formation, behavior, aging, and disease research. This PA is a reissuance of PA-98-074, which was published in the NIH Guide for Grants and Contracts, Vol. 5, No. 22 on May 21, 1998. This effort stems from an NIH initiative with participation of the Institutes and Centers listed above, working though the Trans-NIH Zebrafish Coordinating Committee (TZCC, http://www.nih.gov/science/models/zebrafish/) under the co-chairmanship of NICHD and NIDDK. Since its formation in 1997, the committee has played an active role as an advocate for the zebrafish as an important model for development, organ formation, behavior, aging, and disease research.