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The National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Mental Health (NIMH), National Cancer Institute (NCI), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), and the Tuberous Sclerosis Alliance invite research grant applications aimed at understanding or treating Tuberous Sclerosis Complex (TSC). -This funding opportunity will utilize the R03 mechanism, but runs in parallel with two program announcements of identical scientific scope that utilize the traditional research project grant (R01) [PAS-05-085] and exploratory/developmental research grant (R21) [PAS-06-206] grant mechanisms, respectively. -The participating organizations intend to commit a total of $2,000,000 to this Program Announcement with set-aside funds (PAS) and two other Program Announcements of identical scientific scope that utilize the R01 and R21 mechanisms. These funds are in addition to funds available for applications sent in response to these announcements that score within the paylines of the participating NIH Institutes. -Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. -Project Period and Award Levels: A total project period of up to two years and a budget for direct costs of up to two $25,000 modules or $50,000 per year may be requested. -Eligible organizations include: For-profit organizations; Non-profit organizations; Public or private institutions, such as universities, colleges, hospitals, and laboratories; Eligible agencies of the Federal government; Units of State government; Units of local government ; Foreign Institutions; Domestic Institutions; Faith-based or community-based organizations; and units of state or local tribal governments. -Eligible Project Directors/Principal Investigators (PD/PIs): Any individual with the skills, knowledge and resources necessary to carry out the proposed research, is invited to work with his/her institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. -An R03 is not renewable. 

The National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Mental Health (NIMH), National Cancer Institute (NCI), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), and the Tuberous Sclerosis Alliance invite research grant applications aimed at understanding or treating Tuberous Sclerosis Complex (TSC). -This funding opportunity will utilize the R21 mechanism, but runs in parallel with two program announcements of identical scientific scope utilize the traditional research project grant (R01) [PAS-05-085] and small research grant (R03) [PAS-06-205] mechanisms, respectively. -The participating organizations intend to commit a total of $2,000,000 to this Program Announcement with set-aside funds (PAS) and two other Program Announcements of identical scientific scope that utilize the R01 and R03 mechanisms. These funds are in addition to funds available for applications sent in response to these announcements that score within the paylines of the participating NIH Institutes. -Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. -Project Period and Award Levels: The total project period for an application submitted in response to this funding opportunity may not exceed two years. Direct costs are limited to $275,000 over an R21 two-year period, with no more than $200,000 in direct costs allowed in any single year. -Eligible organizations: For profit organizations; Non-profit organizations; Public or private institutions, such as universities, colleges, hospitals and laboratories; Units of State government; Units of local government; Eligible institutions of the Federal government; Domestic institutions; Foreign institutions; Faith-based or community-based organizations; Units of State Tribal government; and Units of Local Tribal government. -Eligible Project Directors/Principal Investigators (PD/PIs): Any individual with the skills, knowledge and resources necessary to carry out the proposed research, is invited to work with his/her institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. -Applicants may submit more than one application, provided each application is scientifically distinct. -An R21 is not renewable. 

The National Institute of Neurological Disorders and Stroke (NINDS), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), and the National Institute of Child Health and Human Development (NICHD) solicit applications for translational research projects in muscular dystrophy. Several emerging pathways to treatment of muscular dystrophy show promise, ranging from palliative therapies that can markedly delay onset or progression of the disease to genetic or stem cell approaches that may reverse or eliminate the condition. The objective of this initiative is to encourage the pursuit of a broad range of translational research strategies for therapeutic development in muscular dystrophy. This Funding Opportunity Announcement (FOA) solicits exploratory/developmental applications that will provide the leads, tools, and resources needed for a subsequent therapy development project. Applications are encouraged for translational research exploratory/developmental projects for any one or more of the muscular dystrophies.

The National Institute of Neurological Disorders and Stroke (NINDS) invites applications for studying the integration of neurobiological and cerebrovascular mechanisms in the adult, aged and pediatric brain in health and disease.

The goal of this Funding Opportunity Announcement (FOA) is to promote studies that 1) identify the properties of brain tumor cells that cause them to migrate; 2) determine how interaction of tumor cells with normal brain elements affects migration; and 3) translate understanding of these parameters into interventions that target invading tumor cells.

The goal of this Funding Opportunity Announcement (FOA) is to solicit applications on lysosomal storage disorders (LSDs) focused on improving CNS treatment outcomes, enhancing the effectiveness of delivery and targeting of cells, enzymes, drugs and genes into the brain, and developing novel therapeutic modalities, such as implantable biocapsules and micro-electro-mechanical systems (MEMS)-based devices.

The NIMH, NIDA, and NINDS request competing renewal applications from the current grant recipients of RFA-MH-01-009, Institutional Training Programs: Increasing Diversity which were funded in FY 2002. The goal of the Increasing Diversity T32 program is to help ensure that a diverse pool of highly trained scientists is available in adequate numbers and in appropriate research areas to address the Nation's biomedical, behavioral, and clinical research needs in research areas relevant to the NIMH, and/or NIDA, and/or NINDS. Only those T32 programs previously awarded as a result of RFA-MH-01-009 that were funded in FY 2002 are eligible to respond to this announcement. Pre- and postdoctoral candidates selected to participate in these training programs must be from underrepresented ethnic and racial groups, and/or individuals with disabilities, and/or individuals from disadvantaged backgrounds. For eligibility criteria for the above-mentioned categories, please see Section III.1. Trainees supported under this mechanism must be U.S. citizens, non-citizen nationals, or individuals lawfully admitted for permanent residence, (i.e., in possession of the Alien Registration Receipt Card I-551 or some other legal verification of such status) by the time of the trainee appointment. Non-citizen nationals are generally persons born in outlying possessions of the United States (i.e., American Samoa and Swains Island). An individual admitted lawfully for permanent residence must submit with the application a notarized statement indicating possession of the Alien Registration Receipt Card I-551. Individuals on temporary or student visas are not eligible. Because the nature and scope of the proposed research training will vary from application to application, it is anticipated that the size of each award will also vary. The total amount awarded and the number of awards will depend upon the quality, duration, and quality of the applications received. Eligible Program Directors include any individual with the knowledge, skills, successful past training records, and available resources necessary to carry out the proposed research training program. Program Directors should have a strong and active track record in research, training, and administration that are essential to conduct and manage the proposed research training program. Awards for Institutional Research Training Grants may be for project periods up to five years in duration. Awards are made in 12-month increments. Trainees are required to pursue full-time research training, which is normally defined as 40 hours per week, or as specified by the sponsoring institution in accordance with its own policies. Institutional research training grants may not be transferred from one institution to another.

The National Institutes of Health and the Canadian Institutes of Health Research invite applications to participate in the Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine (Network), a cooperative network of academic centers with clinically active cardiothoracic surgeons and their colleagues in allied specialties interested in promulgating the use of evidence-based medicine in surgical practice. The goal of the Network is to foster a culture of rigorous scientific comparisons and promote the evaluation of newer surgical techniques, technologies, devices, and innovative pharmaceutical and bioengineered products directed at cardiovascular disease.The Network will allow research teams led by cardiac surgeons to evaluate, by the most rigorous methods possible, newer therapies and techniques as they move from laboratory science to broad clinical use.The Network will enhance the capacity to disseminate study results, and translate findings to large-scale trials or practice. The program will provide support to maintain the necessary infrastructure to develop, coordinate, and conduct multiple collaborative proof-of-concept clinical studies and interventional protocols to improve cardiovascular disease outcomes.

The National Institute of Neurological Disorders and Stroke (NINDS) encourages submission of investigator-initiated research grant applications to study mechanisms of transmission and dissemination of Transmissible Spongiform Encephalopathies (TSEs). -This funding opportunity announcement (FOA) will utilize the NIH Small Grant (R03) award mechanism, but runs in parallel with two program announcements of identical scientific scope that utilize the traditional research project grant (R01) [PA-06-191] and exploratory/developmental research grant (R21) [PA-06-193] mechanisms, respectively. -Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. -Project Period and Award Levels: A total project period of up to two years and a budget for direct costs of up to two $25,000 modules or $50,000 per year may be requested. -Eligible organizations include: For-profit organizations; Non-profit organizations; Public or private institutions, such as universities, colleges, hospitals, and laboratories; Eligible agencies of the Federal government; Units of State government; Units of local government ; Foreign Institutions; Domestic Institutions; Faith-based or community-based organizations; and units of state or local tribal governments. -Eligible project directors/principal investigators include: Postdoctoral trained individuals with institutional appointments through Assistant Professor, or equivalent, position. Any individual with the skills, knowledge and resources necessary to carry out the proposed research, is invited to work with his/her institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. -An R03 is not renewable. 

The National Institute of Neurological Disorders and Stroke (NINDS) encourages submission of investigator-initiated research grant applications to study mechanisms of transmission and dissemination of Transmissible Spongiform Encephalopathies (TSEs). -This funding opportunity announcement (FOA) will use the NIH Exploratory/Developmental Grant (R21) award mechanism but runs in parallel with two program announcements of identical scientific scope that utilizes the traditional research project grant (R01) [PA-05-096] and small research grant (R03) mechanisms [PA-06-192], respectively. -Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. -Eligible organizations include: For-profit organizations; Non-profit organizations; Public or private institutions, such as universities, colleges, hospitals, and laboratories; Eligible agencies of the Federal government; Units of State government; Units of local government ; Foreign Institutions; Domestic Institutions; Faith-based or community-based organizations; and units of state or local tribal governments. -Eligible project directors/principal investigators include: Postdoctoral trained individuals with institutional appointments through Assistant Professor, or equivalent, position. Any individual with the skills, knowledge and resources necessary to carry out the proposed research, is invited to work with his/her institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. -An R21 is not renewable.