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This Funding Opportunity Announcement (FOA) encourages small business applications for exploratory clinical trials of investigational agents (drugs, biologics, surgical therapies or devices) that may contribute to the justification for and provide the data required for designing clinical studies. Diseases chosen for study should be based on the NINDS' strategic plan and clinical research interests (www.ninds.nih.gov/funding/areas/index.htm ).

This FOA encourages applications for the Lasker Clinical Research Scholars Program for the purpose of supporting the research activities during the early stage careers of independent clinical researchers.

The purpose of this Funding Opportunity Announcement (FOA) is to support projects that will elucidate the therapeutic potential of the cannabinoids and endocannabinoid system in the development of mechanism-based therapies for pain.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this R25 program is to support educational activities that foster a better understanding of biomedical, behavioral and clinical research and its implications. To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on Research Experiences for high school, undergraduate and science teachers during the summer academic break.

The purpose of this FOA is to support the expansion of the National Institute of Neurological Disorders and Stroke (NINDS) Human Cell and Data Repository. The repository will maintain the current collection of fibroblast and induced pluripotent stem cell (iPSC) lines as well as develop, characterize, expand and where appropriate genetically modify new high-quality iPSC, fibroblast cell lines and peripheral blood monocyte cells in accordance with the NINDS mission. The NINDS Human Cell and Data Repository will distribute human cell resources broadly to qualified academic and industry researchers.

The National Institute of Neurological Disorders and Stroke (NINDS) is soliciting applications for a Human Biospecimen and Data Repository for Biomarkers Research ("Biomarkers Repository") in Neurological Disorders. Collaborative teams combining expertise in neuroscience, biomarkers, biospecimen handling, and data management are encouraged. Experience in biomarker research, such as evaluation of batch effects, protocol development, and analyte quality control measures, is expected. Successful applications will include a detailed description of 1) Administrative Structure, 2) Research and Resource Plan, and 3) Data Management and Web-Based activities.

The Jointly Sponsored NIH Predoctoral Training Program in the Neurosciences (JSPTPN) supports broad and fundamental research training in the neurosciences via institutional NRSA research training grants (T32) at domestic institutions of higher education. Trainees appointed to this training grant are financially supported for either one or two years, during the first 2 years of their graduate research training. The primary objective is to prepare individuals for careers in neuroscience that have a significant impact on the health-related research needs of the Nation.

This Funding Opportunity Announcement (FOA) is issued as an initiative of the NIH Blueprint for Neuroscience Research.The Neuroscience Blueprint is a collaborative framework through which 15 NIH Institutes, Centers and Offices jointly support neuroscience-related research, with the aim of accelerating discoveries and reducing the burden of nervous system disorders (for further information, see http://neuroscienceblueprint.nih.gov/).The Neuroscience Blueprint is supporting a Lifespan Human Connectome Project (L-HCP) to extend the Human Connectome Project (HCP) (http://www.neuroscienceblueprint.nih.gov/connectome) to map connectivity in the developing, adult, and aging human brain.The goal of this FOA is to solicit grant applications that propose to extend the experimental protocols developed through the HCP to children in the 0-5 year old age range to investigate the structural and functional changes that occur in the brain during typical development.Related FOAs solicit applications that apply the HCP protocols to the 5-21 year old age range and to middle age and elderly adults to explore changes that occur during normal aging.

This Funding Opportunity Announcement (FOA) invites research grant applications focused on defining the central role of exosomes in the neuropathogenesis of Human Immunodeficiency Virus (HIV)-1 Associated Neurocognitive Disorders (HAND) and determining the potential use of exosomes as biomarkers for HAND or as delivery vehicles for CNS targeted therapeutics. Basic and translational research in domestic and international settings is of interest.Multidisciplinary research teams and collaborative alliances are encouraged but not required.

This Funding Opportunity Announcement (FOA) invites small research grant applications focused on defining the central role of exosomes in the neuropathogenesis of Human Immunodeficiency Virus (HIV)-1 Associated Neurocognitive Disorders (HAND) and determining the potential use of exosomes as biomarkers for HAND or as delivery vehicles for CNS targeted therapeutics. Basic and translational research in domestic and international settings is of interest.Multidisciplinary research teams and collaborative alliances are encouraged but not required.