Charcot-Marie-Tooth Disease Information Page

Charcot-Marie-Tooth Disease Information Page


What research is being done?

Ongoing research on CMT includes efforts to identify more of the mutant genes and proteins that cause the various disease subtypes. Other research aims to discover the mechanism of muscle atrophy and nerve degeneration, with the goal of developing ways to stop or slow these processes and develop therapies to reverse the damage. Additional research focuses on protein regulation and how the mitochondria, thr cell's power plant, may play a role in nerve degeneration.

Information from the National Library of Medicine’s MedlinePlus
Charcot-Marie-Tooth Disease

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What research is being done?

Ongoing research on CMT includes efforts to identify more of the mutant genes and proteins that cause the various disease subtypes. Other research aims to discover the mechanism of muscle atrophy and nerve degeneration, with the goal of developing ways to stop or slow these processes and develop therapies to reverse the damage. Additional research focuses on protein regulation and how the mitochondria, thr cell's power plant, may play a role in nerve degeneration.

Information from the National Library of Medicine’s MedlinePlus
Charcot-Marie-Tooth Disease

Ongoing research on CMT includes efforts to identify more of the mutant genes and proteins that cause the various disease subtypes. Other research aims to discover the mechanism of muscle atrophy and nerve degeneration, with the goal of developing ways to stop or slow these processes and develop therapies to reverse the damage. Additional research focuses on protein regulation and how the mitochondria, thr cell's power plant, may play a role in nerve degeneration.

Information from the National Library of Medicine’s MedlinePlus
Charcot-Marie-Tooth Disease


Definition
Definition
Treatment
Treatment
Prognosis
Prognosis
Clinical Trials
Clinical Trials
Organizations
Organizations
Publications
Publications
Definition
Definition

Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders, and nearly all cases are inherited. CMT damages the body's peripheral nerves, making them unable to activate muscles or relay sensory informaton from the limbs back to the spinal cord and the brain. There are different types of CMT disease, which may share some symptoms but vary by pattern of inheritance and age of onset. Early symptoms typically include weakness or paralysis of the foot and lower leg muscles. As the disease progresses, weakness and decreased muscle bulk my occur in the hands, arms, legs, or feet. People may lose the ability to feel heat, cold, and touch. Chronic shortening of muscles or tendons around joints prevents the joints from moving freely, and muscle cramping is common. Some people have pain that can range from mild to severe. Genetic testing can detect the most common types of CMT.

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Definition

Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders, and nearly all cases are inherited. CMT damages the body's peripheral nerves, making them unable to activate muscles or relay sensory informaton from the limbs back to the spinal cord and the brain. There are different types of CMT disease, which may share some symptoms but vary by pattern of inheritance and age of onset. Early symptoms typically include weakness or paralysis of the foot and lower leg muscles. As the disease progresses, weakness and decreased muscle bulk my occur in the hands, arms, legs, or feet. People may lose the ability to feel heat, cold, and touch. Chronic shortening of muscles or tendons around joints prevents the joints from moving freely, and muscle cramping is common. Some people have pain that can range from mild to severe. Genetic testing can detect the most common types of CMT.

Treatment
Treatment

There is no cure for CMT, but physical therapy, occupational therapy, braces and other orthopedic devices, and orthopedic surgery can help people cope with the disabling symptoms of the disease. In addition, pain-killing drugs can be prescribed for individuals who have severe pain.

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Treatment

There is no cure for CMT, but physical therapy, occupational therapy, braces and other orthopedic devices, and orthopedic surgery can help people cope with the disabling symptoms of the disease. In addition, pain-killing drugs can be prescribed for individuals who have severe pain.

Definition
Definition

Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders, and nearly all cases are inherited. CMT damages the body's peripheral nerves, making them unable to activate muscles or relay sensory informaton from the limbs back to the spinal cord and the brain. There are different types of CMT disease, which may share some symptoms but vary by pattern of inheritance and age of onset. Early symptoms typically include weakness or paralysis of the foot and lower leg muscles. As the disease progresses, weakness and decreased muscle bulk my occur in the hands, arms, legs, or feet. People may lose the ability to feel heat, cold, and touch. Chronic shortening of muscles or tendons around joints prevents the joints from moving freely, and muscle cramping is common. Some people have pain that can range from mild to severe. Genetic testing can detect the most common types of CMT.

Treatment
Treatment

There is no cure for CMT, but physical therapy, occupational therapy, braces and other orthopedic devices, and orthopedic surgery can help people cope with the disabling symptoms of the disease. In addition, pain-killing drugs can be prescribed for individuals who have severe pain.

Prognosis
Prognosis

Onset of symptoms of CMT is most often in adolescence or early adulthood but can occur at any age. Progression of symptoms is very gradual. CMT affects both sensory and motor nerves (nerves that trigger an impulse for a muscle to contract). In addition to a reduced ability to feel vibrations, temperature differences, and touch, weakness and muscle atrophy in the hands may cause difficulty with fine motor skills. The disease can cause curvature of the spine and hip displacement. Most individuals with CMT have some amount of physical disability, although some people may never know they have the disease.  CMT usually isn't life threatening and rarely affects muscles involved in vital functions like breathing.

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Onset of symptoms of CMT is most often in adolescence or early adulthood but can occur at any age. Progression of symptoms is very gradual. CMT affects both sensory and motor nerves (nerves that trigger an impulse for a muscle to contract). In addition to a reduced ability to feel vibrations, temperature differences, and touch, weakness and muscle atrophy in the hands may cause difficulty with fine motor skills. The disease can cause curvature of the spine and hip displacement. Most individuals with CMT have some amount of physical disability, although some people may never know they have the disease.  CMT usually isn't life threatening and rarely affects muscles involved in vital functions like breathing.

Prognosis
Prognosis

Onset of symptoms of CMT is most often in adolescence or early adulthood but can occur at any age. Progression of symptoms is very gradual. CMT affects both sensory and motor nerves (nerves that trigger an impulse for a muscle to contract). In addition to a reduced ability to feel vibrations, temperature differences, and touch, weakness and muscle atrophy in the hands may cause difficulty with fine motor skills. The disease can cause curvature of the spine and hip displacement. Most individuals with CMT have some amount of physical disability, although some people may never know they have the disease.  CMT usually isn't life threatening and rarely affects muscles involved in vital functions like breathing.

Definition

Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders, and nearly all cases are inherited. CMT damages the body's peripheral nerves, making them unable to activate muscles or relay sensory informaton from the limbs back to the spinal cord and the brain. There are different types of CMT disease, which may share some symptoms but vary by pattern of inheritance and age of onset. Early symptoms typically include weakness or paralysis of the foot and lower leg muscles. As the disease progresses, weakness and decreased muscle bulk my occur in the hands, arms, legs, or feet. People may lose the ability to feel heat, cold, and touch. Chronic shortening of muscles or tendons around joints prevents the joints from moving freely, and muscle cramping is common. Some people have pain that can range from mild to severe. Genetic testing can detect the most common types of CMT.

Treatment

There is no cure for CMT, but physical therapy, occupational therapy, braces and other orthopedic devices, and orthopedic surgery can help people cope with the disabling symptoms of the disease. In addition, pain-killing drugs can be prescribed for individuals who have severe pain.

Prognosis

Onset of symptoms of CMT is most often in adolescence or early adulthood but can occur at any age. Progression of symptoms is very gradual. CMT affects both sensory and motor nerves (nerves that trigger an impulse for a muscle to contract). In addition to a reduced ability to feel vibrations, temperature differences, and touch, weakness and muscle atrophy in the hands may cause difficulty with fine motor skills. The disease can cause curvature of the spine and hip displacement. Most individuals with CMT have some amount of physical disability, although some people may never know they have the disease.  CMT usually isn't life threatening and rarely affects muscles involved in vital functions like breathing.

What research is being done?

Ongoing research on CMT includes efforts to identify more of the mutant genes and proteins that cause the various disease subtypes. Other research aims to discover the mechanism of muscle atrophy and nerve degeneration, with the goal of developing ways to stop or slow these processes and develop therapies to reverse the damage. Additional research focuses on protein regulation and how the mitochondria, thr cell's power plant, may play a role in nerve degeneration.

Information from the National Library of Medicine’s MedlinePlus
Charcot-Marie-Tooth Disease

Patient Organizations
Charcot-Marie-Tooth Association (CMTA)
P.O. Box 105
Glenolden
PA
Glenolden, PA 19036
Tel: 800-606-CMTA (2682)
Hereditary Neuropathy Foundation, Inc
432 Park Avenue South
4th Floor
New York
NY
New York, NY 10128
Tel: 855-HELPCMT (435-7268); 212-722-8396
Muscular Dystrophy Association
National Office - 222 S. Riverside Plaza
Suite 1500
Chicago
IL
Chicago, IL 60606
Tel: 800-572-1717
Patient Organizations