Translational Stroke Research: Vision and Opportunities Workshop

Translational Stroke Research: Vision and Opportunities Workshop

November 1, 2016
November 2, 2016


Dr. Ipolia Ramadan

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Bldg. 10, Masur Auditorium, NIH campus, Bethesda, MD

Event Description: 

Registration is now open for the NIH/ NINDS sponsored workshop “Translational Stroke Research: Vision and Opportunities”, to be held in the NIH main campus (Bldg. 10, Masur Auditorium), Bethesda, MD, on November 1-2, 2016. The event is free and sponsored by the National Institute of Neurological Disorders and Stroke. Please refer to the link below for the workshop agenda and registration:

The event will also be available via NIH VideoCast (no prior registration required):

Day one:

Day two:

Although stroke risk and mortality have been steadily decreasing over past two decades, thanks to improved prevention strategies and increased and faster access to reperfusion therapies, the attempt to develop new pharmacological treatments for acute stroke has been costly and overall unsuccessful. Current drug treatments are problematic because of the narrow therapeutic window and the risk of hemorrhage, and there is no approved treatment for stroke patients after the acute phase. No pharmacological treatment is currently available to reduce hemorrhagic stroke-induced brain injury.

The overall goal of this workshop is to bring together key stakeholders, including stroke basic scientists and clinicians, members of editorial boards of stroke journals, and representative from industry, FDA, and other public and private funding agencies to identify the steps that need to be taken to improve animal models, experimental design, existing infrastructure and bridging between preclinical and clinical studies in order to improve the success in the development of new therapies for stroke and establish a vision for the field.

Workshop Program:

Session 1: Animal models and outcome measures. What is needed to move translational stroke research forward? To review existing animal models and outcome measures and establish a vision on what is needed to move translational research forward in ischemic and hemorrhagic stroke

Session 2: Opportunities for reverse translation: from bed-to-bench-side. Perspectives from StrokeNet regarding opportunities in reverse-translation, and harmonization of data-sharing, toolbox, and common data elements.

Session 3: Approaches in preclinical stroke research and lessons learned: What is the path forward? To evaluate potential infrastructures and approaches for preclinical studies with a rigorous experimental design with similar standards applied in human clinical trials.

NINDS Program Staff Organizing Committee: Francesca Bosetti, Rod Corriveau, Lyn Jakeman, Scott Janis, Jim Koenig, Claudia Moy, Ipolia Ramadan, Shai Silberberg, Hao Wang.

Steering committee: Tom Carmichael (University of California Los Angeles), Costantino Iadecola (Weill Cornell Medical School), Louise McCullough (University of Texas Health Science Center, Houston), Joe Broderick (University of Cincinnati), Mike Tymianski (University of Toronto, Canada), Uli Dirnagl (Charité, Germany), Eng Lo (Massachusetts General Hospital), Pat Lyden ( Cedars Sinai), John Zhang (Loma Linda University), Stephen Back (Oregon Health & Science University).