Contact Email: christine.swanson-fischer@nih.gov
Location:
Crowne Plaza Hotel
London, United Kingdom
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Frontotemporal Lobar Degeneration (FTD) includes a complex group of clinical syndromes (behavioral variant FTD, semantic variant primary progressive aphasia, nonfluent/agrammatic variant primary progressive aphasia, logopenic variant primary progressive aphasia, FTD with motor neuron disease, progressive supranuclear palsy syndrome, Pick’s Disease and cortical basal syndrome) and this variation in clinical presentation, in part, defines the complexity of the FTLD sequencing project. In addition to the clinical presentation, the proteinopathies (tau, TDP43, progranulin, fus, C9ORF72) associated with these syndromes are as varied as the genetic mutations that are causative for FTLD.
The workshop will introduce the National Institutes of Health (NIH) sponsored Alzheimer's Disease Related Dementia (ADRD) FTD activities to the larger research community. The workshop will focus on genetic approaches for identifying new gene mutations, genetic modifier identification, data availability, cohort studies and emerging technologies. Ongoing efforts in Parkinson's Disease (PD), Alzheimer's Disease (AD) and FTD sequencing will be presented and a panel discussion will focus on collaborative efforts going forward. Clinical trial preparation will be discussed specifically in reference to the use of genetics in FTD clinical trials.