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What is Gerstmann-Straussler-Scheinker disease?
Gerstmann-Straussler-Scheinker disease (GSS) is an extremely rare, neurodegenerative brain disorder. It is almost always inherited and is found in only a few families around the world. The disease usually begins between the ages of 35 and 55.
In the early stages, people with GSS may experience varying levels of ataxia (lack of muscle coordination), including clumsiness, unsteadiness, and difficulty walking. As the disease progresses, the ataxia becomes more…
… inflammation, muscle weakness, and in some cases, muscle pain. Myopathy is a general term used to describe a number of … inflammation, muscle weakness, and in some cases, muscle pain. The majority of the inflammatory myopathies are …
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What is antiphospholipid syndrome?
Antiphospholipid syndrome (APS) is a rare autoimmune disorder caused when antibodies—immune system cells that fight off bacteria and viruses—mistakenly attack normal proteins in the blood. Specific antibodies activate the inner lining of blood vessels, which leads to the formation of blood clots in arteries or veins in the brain, legs, kidneys, and lungs.
APS is sometimes called “sticky blood syndrome” because of the increased tendency for blood clots to form. A clot that…
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What is Menkes disease?
Menkes disease is caused by mutations in the ATP7A gene that regulates the metabolism of copper in the body. The disease primarily affects male infants. Copper accumulates at abnormally low levels in the liver and brain, but at higher-than-normal levels in the kidney and intestinal lining.
Infants may be born prematurely but appear healthy at birth and for six to eight weeks. Then, symptoms begin. These can include:
- Floppy muscle tone
- Seizures
- …
… longer than an hour. The frequency of episodes varies from person to person, with some people having only one episode a month to … It can affect a few members of a family, or only one person. The cause is unknown but the disorder may be …
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What is pseudotumor cerebri?
Pseudotumor cerebri literally means "false brain tumor." It is likely due to high pressure within the skull caused by the buildup or poor absorption of cerebrospinal fluid (CSF). The disorder is most common in females between the ages of 20 and 50. Symptoms, which closely mimic those of large brain tumors, include:
- Headache
- Nausea
- Vomiting
- Pulsating sounds within the head
Monday, March 11, 2019
This week, we celebrate the most mysterious and fascinating organ in the body—the brain—by participating in Brain Awareness Week, March 11-17. The goal of Brain Awareness Week is to increase public awareness of the brain and the progress and benefits of brain research. NINDS has played an active role in Brain…
… unsettling time for all of us. The rapidly evolving public health emergency associated with the coronavirus disease … number of lives that are at stake and for the safety of health care professionals working on the front lines. I urge … affected with neurological disorders who deal with serious health problems and uncertainty every day. There is probably …
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Decades of research have shown a strong link between cardiovascular and cerebrovascular disease, including stroke, and subsequent cognitive impairment and dementia. Moreover, cerebrovascular disease is exceedingly common in the elderly diagnosed with Alzheimer's disease. Vascular contributions to cognitive impairment & dementia (VCID) encompasses all types of…
… signaling between cells, at synapses and among circuits is the essential scaffold upon which brain function is built. … Nrg1 signaling contribute to these diverse phenotypes. What is the functional significance of heterogeneity in the … to the formation and retrieval of specific memories, and what factors distinguish cholinergic neurons that are …