Objective The goals of this pilot study are to establish a normative database of vital signs, cognitive function and unusual subjective sensations in a 0T scanner. This data will be used as a reference for a future study of the effects of exposure to a 11.7T static magnetic field. Study Population 26 healthy volunteers, aged 22-65. Accrual ceiling =50 Accrual Target =26 Drop outs will be replaced Design The study consists of one outpatient screening session and one experimental session. Informed consent and a history and neurological examination will be carried out at the screening visit. Vital signs (pulse oximeter, heart rate, respiratory rate and skin temperature) will be measured immediately before and after the experimental scan session, and pulse oximeter, heart rate and respiration will be monitored when the subject is in the scanner. Subjects will remain in the scanner for approximately 1 hour. During the experimental session, while the subject is in the scanner, they will be asked to carry out a brief test of attention at 10-15 minute intervals, up to 3 times during the session. At the end of the experimental session, subjects will fill out the MRI exit questionnaire to rate subjective sensations such as nausea, vertigo, and lightheadedness, on a Likert scale and complete a computerized neuro-cognitive test battery. Outcome Measures The objective of the study is to obtain a normative dataset of neuropsychological test measures, physiological parameters, and subjective experiences measures in subjects undergoing 0T exposure.
- INCLUSION CRITERIA: - 22 - 65 years of age - In good general health - Able to understand the procedures and requirements and give informed consent - Fluent in English EXCLUSION CRITERIA: All Subjects will answer the NMR safety screening form and the Healthy volunteer form A subject will be excluded if he/she: - Has any implanted medical device - Underwent brain surgery, have a central nervous system illness, a neurological lesion or history of neurological or psychiatric disorders - Medical problems, such as diabetes mellitus, hypertension, pulmonary or airway disease, heart failure, coronary artery disease, history of sleep apnea - Diagnosable substance dependence - Consumes more than 1 alcoholic drink per day for women and up to 2 drinks per day for men on a regular basis - Has any metal in their body due to by trauma or surgery - Cannot lie comfortably on their back for up to 60 minutes - Is pregnant - Have sustained shrapnel injuries - Has worked as a machinist, or other occupations that have resulted in metal shavings in their eye - Has claustrophobia - Has known hearing problems