MS is an autoimmune disease in which the immune system (white bloods cells that normally fight infection) becomes misdirected and attacks healthy tissue. In patients with MS, the misdirected white blood cells attack myelin, a lining that insulates the nerves found in the brain and spinal cord. This results in inflammation and damage in the myelin. Loss of this protective lining disrupts nerve impulses and causes abnormal function in the nervous system. This large research study will ultimately enroll 5000 subjects who are at risk of developing MS.
Inclusion Criteria: - First Degree Relatives of Patients with MS, or - Patients who have received anti-TNFa therapy as treatment for inflammatory diseases other than MS such as Crohn's disease, psoriasis and rheumatoid arthritis, or - Patients that have been referred for an evaluation of first presentation of neurologic symptoms but do not have a diagnosis of MS - Live in the United States Exclusion Criteria: - Does not match any of the inclusion criteria