Objective Humans develop skilled movements such as using a spoon or dancing a waltz through a process known as "motor learning. Harnessing this innate process for its therapeutic potential is an attractive strategy to help patients suffering from diseases of movement disorders, yet we do not yet fully understand the normal phenomenon. This study will utilize new paradigms to explore the physiology of motor learning. It will test the validity of a traditional motor learning task that has been modified to invoke the mirror neuron system and odor conditioning. Additionally, by taking advantage of the unique opportunity to assess motor learning awareness immediately following the task, it will also explore this behavioral-cognitive relationship. Thus, this work will lay the foundation for further physiologic characterization of a novel motor learning technique and may support the development of future therapies. Study Population We will study up to one hundred fifty-two healthy, right-handed volunteers who are 18 to 50 years old. Design In phase I of the study, volunteers will be seated in front of a computer monitor with their right hands on a keyboard and respond to visual cues presented on the monitor by pressing the associated, finger-specific keys as quickly and accurately as possible. Each volunteer will be presented only the standard visuospatial or the novel mirror cues, defining the two reaction time task paradigms and experimental groups. In phases II and III of the study, a similar task will take place while subjects undergo magnetic resonance imaging scanning either in the presence or absence of an odor. In addition to the motor learning tasks above, volunteers will have the option to participate in genetic testing for normal genetic variability that may affect motor learning. Outcome Measure The primary outcomes are motor learning and awareness, which will be measured by the key-press reaction time and accuracy, respectively.
- INCLUSION CRITERIA: - Age 18-50 years - Right-handedness EXCLUSION CRITERIA: - Arthritis or other physically limiting disability, amputation, or significant trauma of either hand - Professional musician or stenographer - Persistent neurologic deficit of cognition, movement, or sensation or any history of a central nervous system lesion - Regular use of any neurotropic or psychotropic medication (e.g., narcotic analgesic, anxiolytic, anti-histamine) or any use within twenty-four hours of the motor learning task. - Blindness or visual acuity lower than necessary to distinguish visual stimuli on the display monitor - Impaired decisional capacity or inability to provide informed consent - Previous experience with a serial reaction time task type of study - Nasopharyngeal illness, injury, or dysfunction (Phase III only) - Inability to smell odorized air during screening exam (Phase III only) - Pregnancy (Phases II and III only)