Effect of Sirolimus on Molecular Alterations in Cerebral Aneurysms

Inclusion Criteria: 1. Undergoing one of the following procedures at Jackson Memorial Hospital: - Clipping of an unruptured cerebral artery aneurysm - Endovascular treatment of unruptured cerebral aneurysms (including those receiving coiling) 2. ≥ 18 years of age 3. Willing and able to give informed consent Exclusion Criteria: 1) Subjects meeting any of the following criteria will be excluded: - Dissecting, traumatic, or mycotic brain aneurysm. - Women who are pregnant, or have a positive urine or blood (β-hCG) pregnancy test. - Women who are breastfeeding. - Any clinically significant psychiatric or psychological disease, which would preclude the patient from completing the protocol. - Patients with known Human Immunodeficiency Virus (HIV) infection or other known immunodeficiency. - Patient with renal or liver failure - Interstitial pneumonitis - History of lymphoma - History of skin cancer - Hypersensitivity to sirolimus - Severe or unstable concomitant condition disease or chronic condition, which in the opinion of the investigator could affect assessment of the safety or efficacy of study intervention.