OBJECTIVE: The present study is aimed to clarify which structure or network of structures are responsible for the temporal linkage in bimanual co-ordination in healthy humans. STUDY POPULATION: Healthy normal volunteers. DESIGN: fMRI: Anatomical MRI and fMRI sequences are performed to obtain blood-oxygenation level-dependent (BOLD) imaging of brain activation during which movement performance will be measured with respect to movement synchrony, movement speed and amplitude. Multi-channel EEG recording performed while motor performance is monitored. OUTCOME MEASURES: fMRI: BOLD will be obtained using baseline correction. EEG: band-power and inter-regional coherence will be calculated using baseline correction.
- INCLUSION CRITERIA: 1. Forty normal volunteers ranging from 21 to 75 will be included. Normal volunteers would be recruited from people who are registered as HMCS Normal Volunteers. All subjects should have a valid Clinical Center Medical Record Number. 2. Alcohol abstention is required for all subjects for both fMRI and EEG for 24 hours before the study. EXCLUSION CRITERIA: 1. Normal subjects younger than 21 years and older than 75 will also be excluded from the study since development and decline in movement performance and the associated brain activation is out of the scope of the present study. 2. Normal subjects with MRI findings consistent with organic brain lesions such as brain tumors, stroke, trauma or AVMs will be excluded. 3. Normal subjects with a history of significant medical disorders such as cancers, or requiring continuous treatment with drugs will be excluded. 4. Subjects with mental disorders will be excluded. 5. We will not scan pregnant women because safety of high magnetic field to fetus is not established. Therefore, we will administer a urine pregnancy test for any female subjects of childbearing potential 24 hours prior to functional MRI scan. Pregnant women will not be excluded from the EEG arm of this protocol.