Note regarding the primary purpose of the study: In the Study Design section, this protocol is classified as "Other", since it is specifically designed to examine the effect of telmisartan administered in conjunction with ART on the size of HIV reservoirs in the central nervous system.
Inclusion Criteria: - Age ≥ 18 years old - Have protocol-defined acute HIV-1 infection - Be part of the SEARCH 010/RV 254 study in Bangkok, Thailand - Ability and willingness to start ART immediately after diagnosis - Availability for follow-up for the duration of the planned study - Systolic blood pressure ≥ 110 mmHg - Agree to undergo lumbar puncture at weeks 0, 48 and 72 - Ability and willingness to provide informed consent. Subjects must understand the study and sign the consent form. Persons who cannot read will have the consent form read to them by a member of the study staff and may then give informed consent by using making a thumb print. Exclusion Criteria: - Pregnancy (current or within the last 6 months) or breastfeeding - Uncontrolled hypertension - Use of thiazolidinediones or other angiotensin receptor blockers class [losartan, irbesartan, olmesartan, valsartan, candesartan (washout permitted)] - Screening laboratory values: absolute neutrophil count < 750 cells/mm3, hemoglobin <10 gm/dL creatinine clearance <30 mL/min (estimated by the Cockcroft-Gault equation using ideal body weight) - Known renal artery stenosis - Known cirrhosis or severe liver disease - Unstable coronary artery disease/angina or decompensated congestive heart failure - Any history of intolerance to any angiotensin receptor blocker - Need for ongoing potassium supplementation - Any contraindication to lumbar puncture such as history of bleeding diathesis or cerebral mass lesion