Press Releases

A genetic mutation linked to ALS prevents motor neurons (pictured above) from getting rid of defective parts.

Neurons' broken machinery piles up in ALS

Wednesday, August 12, 2015

A healthy motor neuron needs to transport its damaged components from the nerve-muscle connection all the way back to the cell body in the spinal cord. If it cannot, the defective components pile up and the cell becomes sick and dies.

Scientists discovered that the protein PINK1 plays a critical role in keeping cells healthy by getting rid of mitochondria (pictured above) that are damaged.

PINK1 protein crucial for removing broken-down energy reactors

Wednesday, August 12, 2015

Cells are powered by tiny energy reactors called mitochondria. When damaged, they leak destructive molecules that can cause substantial harm and eventually kill brain cells. Scientists at the NIH's National Institute of Neurological Disorders and Stroke (NINDS) showed that a protein called PINK1...

Scientists searched the chromosomes of Huntington’s disease patients to find genetic factors that control when symptoms begin.

Scientists adopt new strategy to find Huntington's disease therapies

Friday, August 7, 2015

Scientists searched the chromosomes of more than 4,000 Huntington's disease patients and found that DNA repair genes may determine when the neurological symptoms begin. Partially funded by the National Institutes of Health, the results may provide a guide for discovering new treatments for...

NIH scientists described for the first time how a neuropeptide hormone may activate a G protein-coupled receptor.

Crystal clear images uncover secrets of hormone receptors

Friday, July 31, 2015

Many hormones and neurotransmitters work by binding to receptors on a cell's exterior surface. This activates receptors causing them to twist, turn and spark chemical reactions inside cells. NIH scientists used atomic level images to show how the neuropeptide hormone neurotensin might activate...

Scientists used soft materials to create a brain implant a tenth the width of a human hair that can wirelessly control neurons with lights and drugs.

Futuristic brain probe allows for wireless control of neurons

Thursday, July 16, 2015

A study showed that scientists can wirelessly control the path a mouse walks with just a press of a button. Researchers at the Washington University School of Medicine, St. Louis, and University of Illinois, Urbana-Champaign, created a remote controlled, next-generation tissue implant that...

Progesterone does not significantly improve outcome after traumatic brain injury

Tuesday, June 16, 2015

Results of a phase 3 randomized, placebo-controlled clinical trial suggest that progesterone may not significantly improve outcomes in patients who have suffered a moderate to severe traumatic brain injury.

Scientists found that normal neuronal firing patterns can enhance the growth of brain tumors.

Normal neuronal firing may spark brain tumor growth

Tuesday, June 16, 2015

Using human brain tumor samples, scientists have discovered that normal patterns of nerve cell firing may enhance the growth of cancer cells. They also found that, neuroligin-3 (NLGN3), a gene known to be important for brain cell communication, may influence tumor growth and patient survival,...

Walter J. Koroshetz

NIH Names Walter J. Koroshetz, M.D., Director of the National Institute of Neurological Disorders and Stroke

Thursday, June 11, 2015

National Institutes of Health Director Francis S. Collins, M.D., Ph.D., announced today the selection of Walter J. Koroshetz, M.D., as the Director of the National Institute of Neurological Disorders and Stroke (NINDS). He has served as Acting Director of the NINDS since October, 2014.

Scientists created a mouse model of ALS and FTD caused by mutations in the C9ORF72 gene.

Scientists create mice with a major genetic cause of ALS and FTD

Friday, May 22, 2015

Scientists at Mayo Clinic, Jacksonville, Florida created a novel mouse that exhibits the symptoms and neurodegeneration associated with the most common genetic forms of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), both of which are caused by a...

New findings suggest that MRI machines (such as the one pictured above) may help quickly screen stroke patients for acute treatment.

A SMARTer approach to stroke care

Wednesday, May 13, 2015

Time is critical when it comes to stroke: early treatment is associated with better outcomes. According to the Screening with MRI for Accurate and Rapid stroke Treatment (SMART) study, small changes in quality improvement procedures enabled clinicians to use MRI scans to diagnose stroke patients...