The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, is looking for individuals to participate in clinical studies. Participating in clinical trials allows you to play an active role in research on the nature and causes of many disorders of the brain and nervous system, and to possibly help physician-scientists develop future treatments. The information below is designed to help you quickly learn about actively recruiting research studies for which you or someone you know may be eligible.

Description:

Rolandic epilepsy (RE) is the most common type of childhood epilepsy-affecting more than 50,000 children in the United States-and has a complex genetic inheritance. The seizure prognosis is relatively benign, however, many children with RE also have problems with speech and language, reading, and motor coordination. Symptoms of the disorder overlap with more severe types of epilepsy.[\n\r] The purpose of this study is to find the genes that influence RE and its related traits. Identifying genetic causes for the variants would improve diagnosis and allow for early intervention.[\n\r] Researchers will enroll 1000 children with RE and 3000 controls for participation in the study. The scientists will request medical histories and (salivary) DNA samples from the participants. Participation can be completed by mail and telephone.[\n\r] Results from this study should provide important information regarding diagnosis and prognosis of RE, may be useful in clinical management, and, eventually, may lead to a cure for this and other forms of epilepsy.

Eligibility Criteria:

Inclusion: - typical history of focal seizures - EEG centrotemporal sharp waves - age of onset 3-12 years - no previous epilepsy type (febrile seizures OK) - normal development - normal neurological examination - normal MRI/CT (if done) Exclusion: - only history of secondary generalized seizures - atypical history/semiology - history and EEG inconsistent - abnormal EEG background - very early (12yrs) onset - global neurodevelopmental deficit - deviant neurodevelopment - structural imaging abnormality

Study Design:

Study Location:

New York

Study Website: