The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, is looking for individuals to participate in clinical studies. Participating in clinical trials allows you to play an active role in research on the nature and causes of many disorders of the brain and nervous system, and to possibly help physician-scientists develop future treatments. The information below is designed to help you quickly learn about actively recruiting research studies for which you or someone you know may be eligible.

Description:

The goal of this project is to develop a test to assess frontal lobe function using a rapid, inexpensive, objective, and standardized method, without the need for expertise in cognitive test administration. Such methods would be particularly helpful in traumatic brain injury (TBI), where objective measures are needed, and would greatly expand the capacity to make such assessments in clinical practice and research.

Eligibility Criteria:

Inclusion Criteria: - Able to read, write, speak and understand English - history of having sustained a TBI prior to enrollment. Evidence will be any one of the following 3 criteria: 1. GCS 3 - 12 2. Post-traumatic amnesia > 24 hours 3. TBI-related abnormality on neuroimaging (either CT or MRI). (Some missing information about the initial injury (i.e. documentation of initial GCS) is not necessarily exclusionary if the bulk of the available history is indicative that the patient suffered a TBI and meets the inclusion criteria) Exclusion Criteria: - Multiple sclerosis, pre- or co-existing - Stroke (other than stroke at the time of TBI) - Pre-existing developmental disorder - Pre-existing epilepsy - Pre-existing major depressive disorder - Pre-existing schizophrenia

Study Design:

Study Location:

Maryland