Frontotemporal Dementia Information Page

Frontotemporal Dementia Information Page


What research is being done?

The National Institute of Neurological Disorders and Stroke (NINDS) and other institutes of the National Institutes of Health (NIH) conduct and fund research on FTD. Among several research projects, scientists hope to identify novel genes involved with FTD, perhaps leading to therapeutic approaches where delivery of normal genes would improve or restore brain function.  Clinical imaging may help researchers better understand changes in the brains of people with FTD, as well as help diagnose these disorders.  Other projects are aimed a better understanding the toxic effects of protein buildup and how it is related to the development of FTD and related dementias.

Information from the National Library of Medicine’s MedlinePlus
Pick Disease

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What research is being done?

The National Institute of Neurological Disorders and Stroke (NINDS) and other institutes of the National Institutes of Health (NIH) conduct and fund research on FTD. Among several research projects, scientists hope to identify novel genes involved with FTD, perhaps leading to therapeutic approaches where delivery of normal genes would improve or restore brain function.  Clinical imaging may help researchers better understand changes in the brains of people with FTD, as well as help diagnose these disorders.  Other projects are aimed a better understanding the toxic effects of protein buildup and how it is related to the development of FTD and related dementias.

Information from the National Library of Medicine’s MedlinePlus
Pick Disease

The National Institute of Neurological Disorders and Stroke (NINDS) and other institutes of the National Institutes of Health (NIH) conduct and fund research on FTD. Among several research projects, scientists hope to identify novel genes involved with FTD, perhaps leading to therapeutic approaches where delivery of normal genes would improve or restore brain function.  Clinical imaging may help researchers better understand changes in the brains of people with FTD, as well as help diagnose these disorders.  Other projects are aimed a better understanding the toxic effects of protein buildup and how it is related to the development of FTD and related dementias.

Information from the National Library of Medicine’s MedlinePlus
Pick Disease

Search Disorders

Definition
Definition
Treatment
Treatment
Prognosis
Prognosis
Clinical Trials
Clinical Trials
Organizations
Organizations
Publications
Publications
Definition
Definition

Frontotemporal dementia (FTD) describes a clinical syndrome associated with shrinking of the frontal and temporal anterior lobes of the brain. Originally known as Pick’s disease, the name and classification of FTD has been a topic of discussion for over a century.  The current designation of the syndrome groups together Pick’s disease, primary progressive aphasia, and semantic dementia as FTD.  Some doctors propose adding corticobasal degeneration and progressive supranuclear palsy to FTD and calling the group Pick Complex.  These designations will continue to be debated.  As it is defined today, the symptoms of FTD fall into two clinical patterns that involve either (1) changes in behavior, or (2) problems with language.  The first type features behavior that can be either impulsive (disinhibited) or bored and listless (apathetic) and includes inappropriate social behavior; lack of social tact; lack of empathy; distractability; loss of insight into the behaviors of oneself and others; an increased interest in sex; changes in food preferences; agitation or, conversely, blunted emotions; neglect of personal hygiene; repetitive or compulsive behavior, and decreased energy and motivation.  The second type primarily features symptoms of language disturbance, including difficulty making or understanding speech, often in conjunction with the behavioral type’s symptoms.  Spatial skills and memory remain intact.  There is a strong genetic component to the disease; FTD often runs in families.

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Definition

Frontotemporal dementia (FTD) describes a clinical syndrome associated with shrinking of the frontal and temporal anterior lobes of the brain. Originally known as Pick’s disease, the name and classification of FTD has been a topic of discussion for over a century.  The current designation of the syndrome groups together Pick’s disease, primary progressive aphasia, and semantic dementia as FTD.  Some doctors propose adding corticobasal degeneration and progressive supranuclear palsy to FTD and calling the group Pick Complex.  These designations will continue to be debated.  As it is defined today, the symptoms of FTD fall into two clinical patterns that involve either (1) changes in behavior, or (2) problems with language.  The first type features behavior that can be either impulsive (disinhibited) or bored and listless (apathetic) and includes inappropriate social behavior; lack of social tact; lack of empathy; distractability; loss of insight into the behaviors of oneself and others; an increased interest in sex; changes in food preferences; agitation or, conversely, blunted emotions; neglect of personal hygiene; repetitive or compulsive behavior, and decreased energy and motivation.  The second type primarily features symptoms of language disturbance, including difficulty making or understanding speech, often in conjunction with the behavioral type’s symptoms.  Spatial skills and memory remain intact.  There is a strong genetic component to the disease; FTD often runs in families.

Treatment
Treatment

No treatment has been shown to slow the progression of FTD. Behavior modification may help control unacceptable or dangerous behaviors.  Aggressive, agitated, or dangerous behaviors could require medication.  Anti-depressants have been shown to improve some symptoms.

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Treatment

No treatment has been shown to slow the progression of FTD. Behavior modification may help control unacceptable or dangerous behaviors.  Aggressive, agitated, or dangerous behaviors could require medication.  Anti-depressants have been shown to improve some symptoms.

Definition
Definition

Frontotemporal dementia (FTD) describes a clinical syndrome associated with shrinking of the frontal and temporal anterior lobes of the brain. Originally known as Pick’s disease, the name and classification of FTD has been a topic of discussion for over a century.  The current designation of the syndrome groups together Pick’s disease, primary progressive aphasia, and semantic dementia as FTD.  Some doctors propose adding corticobasal degeneration and progressive supranuclear palsy to FTD and calling the group Pick Complex.  These designations will continue to be debated.  As it is defined today, the symptoms of FTD fall into two clinical patterns that involve either (1) changes in behavior, or (2) problems with language.  The first type features behavior that can be either impulsive (disinhibited) or bored and listless (apathetic) and includes inappropriate social behavior; lack of social tact; lack of empathy; distractability; loss of insight into the behaviors of oneself and others; an increased interest in sex; changes in food preferences; agitation or, conversely, blunted emotions; neglect of personal hygiene; repetitive or compulsive behavior, and decreased energy and motivation.  The second type primarily features symptoms of language disturbance, including difficulty making or understanding speech, often in conjunction with the behavioral type’s symptoms.  Spatial skills and memory remain intact.  There is a strong genetic component to the disease; FTD often runs in families.

Treatment
Treatment

No treatment has been shown to slow the progression of FTD. Behavior modification may help control unacceptable or dangerous behaviors.  Aggressive, agitated, or dangerous behaviors could require medication.  Anti-depressants have been shown to improve some symptoms.

Prognosis
Prognosis

The outcome for people with FTD is poor.  The disease progresses steadily and often rapidly, ranging from less than 2 years in some individuals to more than 10 years in others.  Eventually some individuals with FTD will need 24-hour care and monitoring at home or in an institutionalized care setting. 

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The outcome for people with FTD is poor.  The disease progresses steadily and often rapidly, ranging from less than 2 years in some individuals to more than 10 years in others.  Eventually some individuals with FTD will need 24-hour care and monitoring at home or in an institutionalized care setting. 

Prognosis
Prognosis

The outcome for people with FTD is poor.  The disease progresses steadily and often rapidly, ranging from less than 2 years in some individuals to more than 10 years in others.  Eventually some individuals with FTD will need 24-hour care and monitoring at home or in an institutionalized care setting. 

Definition

Frontotemporal dementia (FTD) describes a clinical syndrome associated with shrinking of the frontal and temporal anterior lobes of the brain. Originally known as Pick’s disease, the name and classification of FTD has been a topic of discussion for over a century.  The current designation of the syndrome groups together Pick’s disease, primary progressive aphasia, and semantic dementia as FTD.  Some doctors propose adding corticobasal degeneration and progressive supranuclear palsy to FTD and calling the group Pick Complex.  These designations will continue to be debated.  As it is defined today, the symptoms of FTD fall into two clinical patterns that involve either (1) changes in behavior, or (2) problems with language.  The first type features behavior that can be either impulsive (disinhibited) or bored and listless (apathetic) and includes inappropriate social behavior; lack of social tact; lack of empathy; distractability; loss of insight into the behaviors of oneself and others; an increased interest in sex; changes in food preferences; agitation or, conversely, blunted emotions; neglect of personal hygiene; repetitive or compulsive behavior, and decreased energy and motivation.  The second type primarily features symptoms of language disturbance, including difficulty making or understanding speech, often in conjunction with the behavioral type’s symptoms.  Spatial skills and memory remain intact.  There is a strong genetic component to the disease; FTD often runs in families.

Treatment

No treatment has been shown to slow the progression of FTD. Behavior modification may help control unacceptable or dangerous behaviors.  Aggressive, agitated, or dangerous behaviors could require medication.  Anti-depressants have been shown to improve some symptoms.

Prognosis

The outcome for people with FTD is poor.  The disease progresses steadily and often rapidly, ranging from less than 2 years in some individuals to more than 10 years in others.  Eventually some individuals with FTD will need 24-hour care and monitoring at home or in an institutionalized care setting. 

What research is being done?

The National Institute of Neurological Disorders and Stroke (NINDS) and other institutes of the National Institutes of Health (NIH) conduct and fund research on FTD. Among several research projects, scientists hope to identify novel genes involved with FTD, perhaps leading to therapeutic approaches where delivery of normal genes would improve or restore brain function.  Clinical imaging may help researchers better understand changes in the brains of people with FTD, as well as help diagnose these disorders.  Other projects are aimed a better understanding the toxic effects of protein buildup and how it is related to the development of FTD and related dementias.

Information from the National Library of Medicine’s MedlinePlus
Pick Disease

Patient Organizations
Association for Frontotemporal Degeneration (AFTD)
Radnor Station Building #2 Suite 320
290 King of Prussia Road
Radnor
PA
Radnor, PA 19087
Tel: 267-514-7221; 866-507-7222
National Institute on Aging (NIA)
National Institutes of Health, DHHS
31 Center Drive, Rm. 5C27 MSC 2292
Bethesda
MD
Bethesda, MD 20892-2292
Tel: 301-496-1752; 800-222-2225; 800-222-4225 (TTY)
The Bluefield Project to Cure Frontotemporal Dementia
637 Carolina Street
San Francisco
CA
San Francisco, CA 94107
Tel: 650-208-3478
Publications

An informational booklet about Frontotemporal Disorders compiled by the National Institute of Neurological Disorders and Stroke (NINDS).

Information booklet about Alzheimer's disease, vascular dementia, and other types of dementia compiled by the National Institute of Neurological Disorders and Stroke (NINDS).

Patient Organizations