Complex Regional Pain Syndrome Information Page

Complex Regional Pain Syndrome Information Page


What research is being done?

NINDS-supported scientists are studying new approaches to treat CRPS and intervene more aggressively after traumatic injury to lower the chances of developing the disorder.  Researchers hope to identify specific cellular and molecular changes in certain nerve cells following nerve injury to better understand the processes that underlie neuroplasticity (the brain’s ability to reorganize or form new nerve connections and pathways following injury or death of nerve cells). Identifying these mechanisms could provide targets for new drug therapies that could improve recovery following regeneration.  Other researchers hope to better understand how CRPS develops by studying immune system activation and changes in nerve connections following a nerve injury.

Information from the National Library of Medicine’s MedlinePlus
Complex Regional Pain

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What research is being done?

NINDS-supported scientists are studying new approaches to treat CRPS and intervene more aggressively after traumatic injury to lower the chances of developing the disorder.  Researchers hope to identify specific cellular and molecular changes in certain nerve cells following nerve injury to better understand the processes that underlie neuroplasticity (the brain’s ability to reorganize or form new nerve connections and pathways following injury or death of nerve cells). Identifying these mechanisms could provide targets for new drug therapies that could improve recovery following regeneration.  Other researchers hope to better understand how CRPS develops by studying immune system activation and changes in nerve connections following a nerve injury.

Information from the National Library of Medicine’s MedlinePlus
Complex Regional Pain

NINDS-supported scientists are studying new approaches to treat CRPS and intervene more aggressively after traumatic injury to lower the chances of developing the disorder.  Researchers hope to identify specific cellular and molecular changes in certain nerve cells following nerve injury to better understand the processes that underlie neuroplasticity (the brain’s ability to reorganize or form new nerve connections and pathways following injury or death of nerve cells). Identifying these mechanisms could provide targets for new drug therapies that could improve recovery following regeneration.  Other researchers hope to better understand how CRPS develops by studying immune system activation and changes in nerve connections following a nerve injury.

Information from the National Library of Medicine’s MedlinePlus
Complex Regional Pain

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Definition
Definition
Treatment
Treatment
Prognosis
Prognosis
Clinical Trials
Clinical Trials
Organizations
Organizations
Publications
Publications
Definition
Definition

Complex regional pain syndrome (CRPS) is a condition marked by severe, prolonged pain that people say feels like a burning sensation, a "pins and needles" sensation, or as if an arm or leg is being squeezed.  The continuous, intense pain  can get worse rather than better over time. CRPS most often affects one of the arms, legs, hands, or feet, and often the pain spreads to include thentire arm or leg.  Common symptoms include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, skin sensitivity, abnormal sweating, and swelling.  Doctors aren’t sure what causes CRPS.  Some people have a confirmed nerve injury that is associated with the disorder, while others do not.  Another theory is that CRPS may be caused by something that triggers an immune system response.

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Definition

Complex regional pain syndrome (CRPS) is a condition marked by severe, prolonged pain that people say feels like a burning sensation, a "pins and needles" sensation, or as if an arm or leg is being squeezed.  The continuous, intense pain  can get worse rather than better over time. CRPS most often affects one of the arms, legs, hands, or feet, and often the pain spreads to include thentire arm or leg.  Common symptoms include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, skin sensitivity, abnormal sweating, and swelling.  Doctors aren’t sure what causes CRPS.  Some people have a confirmed nerve injury that is associated with the disorder, while others do not.  Another theory is that CRPS may be caused by something that triggers an immune system response.

Treatment
Treatment

There is no cure for CRPS and no drug has been approved specifically for the disorder.  Treatments are aimed at relieving painful symptoms.  Doctors may prescribe topical analgesics, antidepressants, corticosteroids, and opioids to relieve pain, but no single drug or combination of drugs has produced consistent long-lasting improvement in symptoms.  Other treatments may include physical therapy, nerve blocks, spinal cord stimulation and other types of neurostimulation, and surgery.

×
Treatment

There is no cure for CRPS and no drug has been approved specifically for the disorder.  Treatments are aimed at relieving painful symptoms.  Doctors may prescribe topical analgesics, antidepressants, corticosteroids, and opioids to relieve pain, but no single drug or combination of drugs has produced consistent long-lasting improvement in symptoms.  Other treatments may include physical therapy, nerve blocks, spinal cord stimulation and other types of neurostimulation, and surgery.

Definition
Definition

Complex regional pain syndrome (CRPS) is a condition marked by severe, prolonged pain that people say feels like a burning sensation, a "pins and needles" sensation, or as if an arm or leg is being squeezed.  The continuous, intense pain  can get worse rather than better over time. CRPS most often affects one of the arms, legs, hands, or feet, and often the pain spreads to include thentire arm or leg.  Common symptoms include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, skin sensitivity, abnormal sweating, and swelling.  Doctors aren’t sure what causes CRPS.  Some people have a confirmed nerve injury that is associated with the disorder, while others do not.  Another theory is that CRPS may be caused by something that triggers an immune system response.

Treatment
Treatment

There is no cure for CRPS and no drug has been approved specifically for the disorder.  Treatments are aimed at relieving painful symptoms.  Doctors may prescribe topical analgesics, antidepressants, corticosteroids, and opioids to relieve pain, but no single drug or combination of drugs has produced consistent long-lasting improvement in symptoms.  Other treatments may include physical therapy, nerve blocks, spinal cord stimulation and other types of neurostimulation, and surgery.

Prognosis
Prognosis

The prognosis for CRPS varies highly from person to person.  Early treatment, particularly rehabilitation, may help with limiting the disorder.  Younger people, children, and teenagers tend to have better outcomes.  Some older adults have good outcomes while others continue to experience severe pain despite treatment.

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The prognosis for CRPS varies highly from person to person.  Early treatment, particularly rehabilitation, may help with limiting the disorder.  Younger people, children, and teenagers tend to have better outcomes.  Some older adults have good outcomes while others continue to experience severe pain despite treatment.

Prognosis
Prognosis

The prognosis for CRPS varies highly from person to person.  Early treatment, particularly rehabilitation, may help with limiting the disorder.  Younger people, children, and teenagers tend to have better outcomes.  Some older adults have good outcomes while others continue to experience severe pain despite treatment.

Definition

Complex regional pain syndrome (CRPS) is a condition marked by severe, prolonged pain that people say feels like a burning sensation, a "pins and needles" sensation, or as if an arm or leg is being squeezed.  The continuous, intense pain  can get worse rather than better over time. CRPS most often affects one of the arms, legs, hands, or feet, and often the pain spreads to include thentire arm or leg.  Common symptoms include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, skin sensitivity, abnormal sweating, and swelling.  Doctors aren’t sure what causes CRPS.  Some people have a confirmed nerve injury that is associated with the disorder, while others do not.  Another theory is that CRPS may be caused by something that triggers an immune system response.

Treatment

There is no cure for CRPS and no drug has been approved specifically for the disorder.  Treatments are aimed at relieving painful symptoms.  Doctors may prescribe topical analgesics, antidepressants, corticosteroids, and opioids to relieve pain, but no single drug or combination of drugs has produced consistent long-lasting improvement in symptoms.  Other treatments may include physical therapy, nerve blocks, spinal cord stimulation and other types of neurostimulation, and surgery.

Prognosis

The prognosis for CRPS varies highly from person to person.  Early treatment, particularly rehabilitation, may help with limiting the disorder.  Younger people, children, and teenagers tend to have better outcomes.  Some older adults have good outcomes while others continue to experience severe pain despite treatment.

What research is being done?

NINDS-supported scientists are studying new approaches to treat CRPS and intervene more aggressively after traumatic injury to lower the chances of developing the disorder.  Researchers hope to identify specific cellular and molecular changes in certain nerve cells following nerve injury to better understand the processes that underlie neuroplasticity (the brain’s ability to reorganize or form new nerve connections and pathways following injury or death of nerve cells). Identifying these mechanisms could provide targets for new drug therapies that could improve recovery following regeneration.  Other researchers hope to better understand how CRPS develops by studying immune system activation and changes in nerve connections following a nerve injury.

Information from the National Library of Medicine’s MedlinePlus
Complex Regional Pain

Patient Organizations
International Research Foundation for RSD/CRPS
1910 East Busch Boulevard
Tampa
FL
Tampa, FL 33612
Tel: 813-907-2312
Reflex Sympathetic Dystrophy Syndrome Association(RSDSA)
P.O. Box 502
99 Cherry Street
Milford
CT
Milford, CT 06460
Tel: 203-877-3790; 877-662-7737
Publications

Reflex Sympathetic Dystrophy Syndrome (also known as Reflex Sympathetic Dystrophy Syndrome, Causalgia) information page compiled by the National Institute of Neurological Disorders and Stroke (NIND

Chronic pain information page compiled by the National Institute of Neurological Disorders and Stroke (NINDS).

Chronic pain information page compiled by the National Institute of Neurological Disorders and Stroke (NINDS)

Patient Organizations