Complex Regional Pain Syndrome Information Page

Complex Regional Pain Syndrome Information Page


What research is being done?

NINDS-supported scientists are studying new approaches to treat CRPS and intervene more aggressively to limit the symptoms and disability associated with the syndrome.  For example, researchers hope to better understand how CRPS develops by studying immune system activation and peripheral nerve injury. Researchers also hope to identify specific cellular and molecular changes in sensory nerve cells following peripheral nerve injury.  Identifying these mechanisms could provide targets for new drug therapies that could improve recovery following peripheral nerve injury and nerve cell regeneration.  

Information from the National Library of Medicine’s MedlinePlus
Complex Regional Pain

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What research is being done?

NINDS-supported scientists are studying new approaches to treat CRPS and intervene more aggressively to limit the symptoms and disability associated with the syndrome.  For example, researchers hope to better understand how CRPS develops by studying immune system activation and peripheral nerve injury. Researchers also hope to identify specific cellular and molecular changes in sensory nerve cells following peripheral nerve injury.  Identifying these mechanisms could provide targets for new drug therapies that could improve recovery following peripheral nerve injury and nerve cell regeneration.  

Information from the National Library of Medicine’s MedlinePlus
Complex Regional Pain

NINDS-supported scientists are studying new approaches to treat CRPS and intervene more aggressively to limit the symptoms and disability associated with the syndrome.  For example, researchers hope to better understand how CRPS develops by studying immune system activation and peripheral nerve injury. Researchers also hope to identify specific cellular and molecular changes in sensory nerve cells following peripheral nerve injury.  Identifying these mechanisms could provide targets for new drug therapies that could improve recovery following peripheral nerve injury and nerve cell regeneration.  

Information from the National Library of Medicine’s MedlinePlus
Complex Regional Pain

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Definition
Definition
Treatment
Treatment
Prognosis
Prognosis
Clinical Trials
Clinical Trials
Organizations
Organizations
Publications
Publications
Definition
Definition

Complex regional pain syndrome (CRPS) is a condition marked by severe, prolonged chronic pain (lasting more than six months) that may be constant. Symptoms vary in intensity and duration.  Some people describe it as a burning sensation, a "pins and needles" sensation, or as if an arm or leg is being squeezed.  The pain may spread to the entire arm or leg, even though the injury may have been only to a finger or toe.  Common symptoms include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, increased sensitivity in the affected area, skin sensitivity, abnormal sweating, and abnormal movement in the affected limb.  In most instances the condition is triggered by a clear history of trauma or injury. CRPS also affects the immune system -- the disorder is more common in individuals with other inflammatory and autoimmune conditions such as asthma.  Limited data also suggests that CRPS may also be influenced by genetics.

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Definition

Complex regional pain syndrome (CRPS) is a condition marked by severe, prolonged chronic pain (lasting more than six months) that may be constant. Symptoms vary in intensity and duration.  Some people describe it as a burning sensation, a "pins and needles" sensation, or as if an arm or leg is being squeezed.  The pain may spread to the entire arm or leg, even though the injury may have been only to a finger or toe.  Common symptoms include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, increased sensitivity in the affected area, skin sensitivity, abnormal sweating, and abnormal movement in the affected limb.  In most instances the condition is triggered by a clear history of trauma or injury. CRPS also affects the immune system -- the disorder is more common in individuals with other inflammatory and autoimmune conditions such as asthma.  Limited data also suggests that CRPS may also be influenced by genetics.

Treatment
Treatment

There is no cure for CRPS and no drug has been approved specifically for the disorder.  Treatments are aimed at relieving painful symptoms.  Doctors may prescribe topical analgesics, antidepressants, corticosteroids, and opioids to relieve pain, but no single drug or combination of drugs has produced consistent long-lasting improvement in symptoms.  Other treatments may include physical therapy, nerve blocks, spinal cord stimulation and other types of neurostimulation, and surgery.

×
Treatment

There is no cure for CRPS and no drug has been approved specifically for the disorder.  Treatments are aimed at relieving painful symptoms.  Doctors may prescribe topical analgesics, antidepressants, corticosteroids, and opioids to relieve pain, but no single drug or combination of drugs has produced consistent long-lasting improvement in symptoms.  Other treatments may include physical therapy, nerve blocks, spinal cord stimulation and other types of neurostimulation, and surgery.

Definition
Definition

Complex regional pain syndrome (CRPS) is a condition marked by severe, prolonged chronic pain (lasting more than six months) that may be constant. Symptoms vary in intensity and duration.  Some people describe it as a burning sensation, a "pins and needles" sensation, or as if an arm or leg is being squeezed.  The pain may spread to the entire arm or leg, even though the injury may have been only to a finger or toe.  Common symptoms include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, increased sensitivity in the affected area, skin sensitivity, abnormal sweating, and abnormal movement in the affected limb.  In most instances the condition is triggered by a clear history of trauma or injury. CRPS also affects the immune system -- the disorder is more common in individuals with other inflammatory and autoimmune conditions such as asthma.  Limited data also suggests that CRPS may also be influenced by genetics.

Treatment
Treatment

There is no cure for CRPS and no drug has been approved specifically for the disorder.  Treatments are aimed at relieving painful symptoms.  Doctors may prescribe topical analgesics, antidepressants, corticosteroids, and opioids to relieve pain, but no single drug or combination of drugs has produced consistent long-lasting improvement in symptoms.  Other treatments may include physical therapy, nerve blocks, spinal cord stimulation and other types of neurostimulation, and surgery.

Prognosis
Prognosis

The prognosis for CRPS varies highly from person to person.  Early treatment, particularly rehabilitation, may help with limiting the disorder.  Younger people, children, and teenagers tend to have better outcomes.  Some older adults have good outcomes while others continue to experience severe pain despite treatment.

×

The prognosis for CRPS varies highly from person to person.  Early treatment, particularly rehabilitation, may help with limiting the disorder.  Younger people, children, and teenagers tend to have better outcomes.  Some older adults have good outcomes while others continue to experience severe pain despite treatment.

Prognosis
Prognosis

The prognosis for CRPS varies highly from person to person.  Early treatment, particularly rehabilitation, may help with limiting the disorder.  Younger people, children, and teenagers tend to have better outcomes.  Some older adults have good outcomes while others continue to experience severe pain despite treatment.

Definition

Complex regional pain syndrome (CRPS) is a condition marked by severe, prolonged chronic pain (lasting more than six months) that may be constant. Symptoms vary in intensity and duration.  Some people describe it as a burning sensation, a "pins and needles" sensation, or as if an arm or leg is being squeezed.  The pain may spread to the entire arm or leg, even though the injury may have been only to a finger or toe.  Common symptoms include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, increased sensitivity in the affected area, skin sensitivity, abnormal sweating, and abnormal movement in the affected limb.  In most instances the condition is triggered by a clear history of trauma or injury. CRPS also affects the immune system -- the disorder is more common in individuals with other inflammatory and autoimmune conditions such as asthma.  Limited data also suggests that CRPS may also be influenced by genetics.

Treatment

There is no cure for CRPS and no drug has been approved specifically for the disorder.  Treatments are aimed at relieving painful symptoms.  Doctors may prescribe topical analgesics, antidepressants, corticosteroids, and opioids to relieve pain, but no single drug or combination of drugs has produced consistent long-lasting improvement in symptoms.  Other treatments may include physical therapy, nerve blocks, spinal cord stimulation and other types of neurostimulation, and surgery.

Prognosis

The prognosis for CRPS varies highly from person to person.  Early treatment, particularly rehabilitation, may help with limiting the disorder.  Younger people, children, and teenagers tend to have better outcomes.  Some older adults have good outcomes while others continue to experience severe pain despite treatment.

What research is being done?

NINDS-supported scientists are studying new approaches to treat CRPS and intervene more aggressively to limit the symptoms and disability associated with the syndrome.  For example, researchers hope to better understand how CRPS develops by studying immune system activation and peripheral nerve injury. Researchers also hope to identify specific cellular and molecular changes in sensory nerve cells following peripheral nerve injury.  Identifying these mechanisms could provide targets for new drug therapies that could improve recovery following peripheral nerve injury and nerve cell regeneration.  

Information from the National Library of Medicine’s MedlinePlus
Complex Regional Pain

Patient Organizations
International Research Foundation for RSD/CRPS
1910 East Busch Boulevard
Tampa
FL
Tampa, FL 33612
Tel: 813-907-2312
Reflex Sympathetic Dystrophy Syndrome Association(RSDSA)
P.O. Box 502
99 Cherry Street
Milford
CT
Milford, CT 06460
Tel: 203-877-3790; 877-662-7737
Publications

Reflex Sympathetic Dystrophy Syndrome (also known as Reflex Sympathetic Dystrophy Syndrome, Causalgia) information page compiled by the National Institute of Neurological Disorders and Stroke (NIND

Chronic pain information page compiled by the National Institute of Neurological Disorders and Stroke (NINDS).

Chronic pain information page compiled by the National Institute of Neurological Disorders and Stroke (NINDS)

Patient Organizations