NINDS congratulates the 2014 Nobel Prize winners in Physiology or Medicine, neuroscientists John M. O’Keefe, Ph.D. (University
College London), May-Britt Moser, Ph.D., and Edvard I. Moser, Ph.D. (Norwegian University of Science and Technology), who
received the award “for their discoveries of cells that constitute a positioning system in the brain.” This research illustrates
how asking questions about basic neuroscience principles can dramatically influence our understanding of brain circuitry and
behavior, and provides insight into disorders of the nervous system.
Advancing the 1948 report by Edward Tolman, Ph.D., who proposed that rats form mental maps to navigate through mazes, Dr. O’Keefe used the best single-cell recording techniques available in the 1960’s and ‘70’s to identify specific "place cells," which encode information in the brain about the environment. Read More ...