Stroke survivors are often left with permanent physical and mental disabilities that create a major social and economic burden. Many of these patients receive different therapies in an attempt to improve their independence and quality of life. However, most of the current strategies are focused on the acute stage after stroke and are of limited influence in improving stroke outcome. One of the main problems of patients who have suffered a stroke is the difficulty in appropriately using the hand contralateral to the lesioned hemisphere; to date we have no successful means to improve the hand function in chronic stages of stroke. This protocol attempts to address this problem. A promising technique is repetitive transcranial magnetic stimulation (rTMS) that, so far, has produced some effects on motor function on other movement disorders like Parkinson's disease (PD). We hypothesize that rTMS will have a beneficial effect on motor function in chronic stroke patients. Specifically, we propose to look at the effect of 20 and 25 Hz stimulation since these types of stimulation have been shown to increase the excitability of the cerebral cortex. The purpose of this protocol is to investigate the effect of repetitive transcranial stimulation (rTMS) on the motor cortex of chronic stroke patients and motor function. Four different stimulation parameters within the limits of current safety guidelines will be used. We plan to determine; 1) which rTMS stimulation parameters induce more cortex excitability, 2) whether there is any improvement of hand motor function after rTMS, and 3) if the applied stimulation parameters are safe in chronic stroke patients. The optimal parameters will be subsequently proposed for use in an experimental protocol for rehabilitation.
- INCLUSION CRITERIA: Fifteen adult and impaired patients (right or left) with residual arm function who have had a single monohemispheric ischemic or hemorrhagic stroke (documented by CT or MRI) at least 6 months before, without severe proprioceptive deficits, independent of previous physical therapy will be included. They should be able to perform the pinch task. Their gender or ethnic origin will not provide bias for inclusion to the study. All subjects will sign an informed consent prior to participation in the trial. EXCLUSION CRITERIA: Exclusion criteria for the trial will include any current actively treated medical or surgical condition or neurological or psychiatric illness other than stroke. Any individual who is on medication which is known to lower seizure threshold, or who has a pacemaker, an implanted medical pump, a metal plate, a metal plate or metal object in the skull or eye (for example after brain surgery) will be excluded. Additional exclusion include patients with: History of more than one stroke; Large cortical, cerebellar, or brainstem lesions; An inability to extend metacarpophalangeal (MP) joints at least 10-20 degrees; Substantially recovered motor function; Severe depression; Poor motivational capacity, or severe language disturbances (particularly of receptive nature); Severe spasticity/pain; Bilateral motor problems; Serious cognitive deficits (defined as equivalent to a mini-mental state exam score of 20 or less); Uncontrolled medical problems, such as: cardiopulmonary disease, severe rheumatoid arthritis, active joint deformity of arthritic origin, active cancer, or renal disease; Uncontrollable issues due to natural aging; History of seizure(s). All patients will underfo electroencephalogram (EEG) examination prior to rTMS experiment as a part of the screening procedure. Patients without any history of seizures, but with any sign of increased cerebral activity in the EEG will be excluded. Women who are pregnant may not participate and women who are of childbearing years must be post-menopausal, sterile, or practicing adequate birth control. Children will be excluded.