R16 First Independent Research Support & Transition (SuRE-First)

Support for investigator-initiated research projects at institutions that receive limited NIH research support and serve underrepresented students.

Program Announcement

Due Dates for New Applications
September 28, 2021, 2022, 2023

PD/PI Eligibility
New investigators

Institution Eligibility
Institutions that receive limited NIH research support and serve students who are underrepresented in biomedical research (see FOA for details)

Additional Information
The SuRE program supports research capacity building at institutions that enroll significant numbers of students from backgrounds nationally underrepresented in biomedical research (see NOT-OD-20-031), award baccalaureate and/or graduate degrees in biomedical sciences, and receive limited NIH Research Project Grant funding. It seeks to develop and sustain research excellence of faculty investigators and provide students with research opportunities while catalyzing institutional research and enriching the research environment. The SuRE program will support investigator-initiated research in the biomedical, clinical, behavioral and social sciences (collectively termed "biomedical" sciences) that falls in the mission areas of NIH Institutes, Centers and Offices. 

SuRE-First awards will support investigators who have not had prior independent external research grants. The SuRE-First Award allows these investigators to develop their independent research programs. A SuRE-First applicant must identify a scientist based in the U.S. with expertise and an extramural funding record in the proposed field of research to serve as a mentor. The mentor may be from the applicant institution or another domestic institution. SuRE-First-supported projects must have student participation in the execution, analysis, and reporting of the research. An applicant institution must demonstrate a commitment to build its research capacity and support the Program Director/Principal Investigator of the award.

NINDS will support applications that address or seek fundamental knowledge about the brain and nervous system by supporting and conducting research on the healthy and diseased brain, spinal cord, and peripheral nerves and to use that knowledge to reduce the burden of neurological disease. NINDS also encourages activities focused on understanding and addressing disparities in neurologic health, healthcare, and health outcomes in disparate populations, including racial and ethnic minorities, the geographically disadvantaged, sex and gender minorities, and others who have been historically underserved, marginalized, and adversely affected by persistent inequality and socioeconomic disadvantage. NINDS supports basic, translational, and clinical research.

A national resource center will provide infrastructure development to SuRE-eligible institutions and application services to faculty investigators.



Lauren Ullrich, PhD | Program Director



SuRE Program Information

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Loan Repayment Program

How to Apply