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Research Category: CounterACT Expiration Date: Friday, January 1, 2027 NOFO Number: NOT-NS-13-004 Release Date: Thursday, December 20, 2012 Notice Type: NOT

Notice Intent Publish Funding Opportunity Announcement Countermeasures Against Chemical Threats CounterACT) Cooperative Research Projects U01) Notice Number: NOT-NS-13-004 Key Dates Release Date: December 20, 2012 Estimated Publication Date Announcement: 1, 2013  First Estimated Application Due Date: September 16, 2013   Earliest Estimated Award Date: July 1, 2014  Earliest Estimated Start Date: July 1, 2014 Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS), intends re-issue Program Announcement Special Review Considerations PAR) solicit applications ldquo;Countermeasures Against Chemical Threats CounterACT) Cooperative Research Projects U01)”. goal this initiative to provide support translational research develop therapeutics reducing mortality morbidity caused acute exposures chemical threat agents. Chemical threats toxic chemicals could used a terrorist attack accidentally released industrial production, storage shipping.  scope the research supported within milestone-driven translational program includes target candidate identification characterization, through candidate optimization demonstration in vivo efficacy, through Investigational New Drug IND) submission.   www.ninds.nih.gov/counteract a description the CounterACT program.  Notice being provided allow potential applicants sufficient time develop meaningful collaborations competitive research programs.  FOA expected be published Spring 2013 an expected application due date September 2013. FOA utilize U01 activity code. Details the planned FOA provided below. Research Initiative Details Notice encourages collaborative multidisciplinary investigations, combining expertise toxicology drug discovery development, discover develop new improved therapeutics treating victims chemical exposures. CounterACT research program utilize Research Project - Cooperative Agreements U01) support Research Projects up 5 years translational research.  research project must establish milestones include discrete quantitative goals create or no-go decision points the project.  Chemical threats be covered include chemical warfare agents e.g. sarin, VX), Toxic Industrial Chemicals e.g. phosgene, sulfur dioxide) others. Please contact NIH Program Director below discuss chemical threats be covered.  NIH intends commit approximately 2-3 million per year Fiscal Years 2014, 2015, 2016 fund new and/or competing renewal U01 awards.  Since nature scope the proposed research vary application application, is anticipated the size duration each award also vary. total amount awarded the number awards depend the number, quality, duration, costs the applications received.  is anticipated several NIH Institutes, including National Eye Institute NEI), National Institute Allergy Infectious Diseases NIAID), National Institute Arthritis Musculoskeletal Skin Diseases NIAMS), Eunice Kennedy Shriver National Institute Child Health Human Development NICHD), National Institute Environmental Health Sciences NIEHS), the National Institute General Medical Sciences NIGMS), also participate this funding opportunity announcement.  APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: David A. Jett, Ph.D. Program Director, NIH CounterACT Research National Institutes Health, NINDS 6001 Executive Blvd. NSC, Room 2177, MSC 9527 Bethesda, MD 20892-9527 Telephone: 301-496-6035 Fax: 301-402-1501 Email: jettd@ninds.nih.gov

Research Category: CounterACT Expiration Date: Friday, January 1, 2027 NOFO Number: NOT-NS-13-005 Release Date: Thursday, December 20, 2012 Notice Type: NOT

Notice Intent Publish Funding Opportunity Announcement Countermeasures Against Chemical Threats CounterACT) Research Centers Excellence U54) Notice Number: NOT-NS-13-005 Key Dates Release Date: December 20, 2012 Estimated Publication Date Announcement: 1, 2013  First Estimated Application Due Date: September 16, 2013   Earliest Estimated Award Date: July 1, 2014  Earliest Estimated Start Date: July 1, 2014 Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS), intends re-issue Program Announcement Special Review Considerations PAR) solicit applications ldquo;Countermeasures Against Chemical Threats CounterACT) Research Centers Excellence U54)”. goal this initiative to provide support translational research develop therapeutics reducing mortality morbidity caused acute exposures chemical threat agents. Chemical threats toxic chemicals could used a terrorist attack accidentally released industrial production, storage shipping.  scope the research supported within milestone-driven translational program includes target candidate identification characterization, through candidate optimization demonstration in vivo efficacy, through Investigational New Drug IND) submission.  www.ninds.nih.gov/counteract a description the CounterACT program.  Notice being provided allow potential applicants sufficient time develop meaningful collaborations competitive research programs.  FOA expected be published Spring 2013 an expected receipt date September 2013. FOA utilize U54 activity code. Details the planned FOA provided below. Research Initiative Details Notice encourages collaborative multidisciplinary investigations, combining expertise toxicology drug discovery development, discover develop new improved therapeutics treating victims chemical exposures. CounterACT research program utilize Specialized Center Cooperative Agreements U54) support Research Centers Excellence up 5 years translational research.  Research Center must establish milestones include discrete quantitative goals create or no-go decision points the project.   Each Center include several individual research projects scientific administrative cores create interdisciplinary synergistic multifaceted research approach, centered a central common goal.  Chemical threats be covered include chemical warfare agents e.g. sarin, VX), Toxic Industrial Chemicals e.g. phosgene, sulfur dioxide) others.  Please contact NIH Program Director below discuss chemical threats be covered.    The NIH intends commit approximately 3-4 million per year Fiscal Years 2014, 2015, 2016 fund new and/or competing renewal U54 awards.  Since nature scope the proposed research vary application application, is anticipated the size duration each award also vary. total amount awarded the number awards depend the number, quality, duration, costs the applications received.  is anticipated several NIH Institutes, including National Eye Institute NEI), National Institute Allergy Infectious Diseases NIAID), National Institute Arthritis Musculoskeletal Skin Diseases NIAMS), Eunice Kennedy Shriver National Institute Child Health Human Development NICHD), National Institute Environmental Health Sciences NIEHS), the National Institute General Medical Sciences NIGMS), also participate this funding opportunity announcement.  APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: David A. Jett, Ph.D. Program Director, NIH CounterACT Research National Institutes Health, NINDS 6001 Executive Blvd. NSC, Room 2177, MSC 9527 Bethesda, MD 20892-9527 Telephone: 301-496-6035 Fax: 301-402-1501 Email: jettd@ninds.nih.gov

Research Category: CounterACT Expiration Date: Friday, January 1, 2027 NOFO Number: NOT-NS-10-011 Release Date: Friday, March 5, 2010 Notice Type: NOT

Notice Intent Publish Funding Opportunity Announcements Countermeasures Against Chemical Threats CounterACT) Cooperative Research Projects U01) Research Centers Excellence U54) Notice Number: NOT-NS-10-011 Key Dates Release Date: March 5, 2010 Issued National Institute Neurological Disorders Stroke NINDS) http://www.ninds.nih.gov) Purpose nbsp; National Institute Neurological Disorders Stroke NINDS) intends issue Funding Opportunity Announcements FOAs) the spring 2010: ldquo;Countermeasures Against Chemical Threats CounterACT) Research Centers Excellence U54)” ldquo;Countermeasures Against Chemical Threats CounterACT) Cooperative Research Projects U01)”.  goal both initiatives to provide support translational research develop therapeutics reducing mortality morbidity caused acute exposures chemical threat agents. Chemical threats toxic chemicals could used a terrorist attack accidentally released industrial production, storage shipping.  scope the research supported within milestone-driven translational program includes target candidate identification characterization, through candidate optimization demonstration in vivo efficacy, through Investigational New Drug IND) submission clinical trials appropriate.   www.ninds.nih.gov/counteract a description the CounterACT program.  CounterACT research program utilize Research Centers Excellence U54) Cooperative Research Projects U01) support to 5 years translational research.  Chemical threats be covered include pulmonary agents e.g. chlorine, phosgene), toxic industrial chemicals e.g. cyanide, pesticides), chemical nerve agents e.g. sarin, VX), others.  NIH intends commit approximately 12 million per year Fiscal Years 2011, 2012, 2013 fund new and/or competing renewal U01 U54 awards.  Because nature scope the proposed research vary application application, is anticipated the size duration each award also vary. total amount awarded the number awards depend the number, quality, duration, costs the applications received.  is anticipated several NIH Institutes, including National Eye Institute NEI), National Institute Allergy Infectious Diseases NIAID), National Institute Arthritis Musculoskeletal Skin Diseases NIAMS), Eunice Kennedy Shriver National Institute Child Health Human Development NICHD), National Institute Environmental Health Sciences NIEHS), the National Institute General Medical Sciences NIGMS), also participate this funding opportunity announcement.  notice being provided allow potential applicants sufficient time develop responsive projects.  APPLICATIONS NOT BEING REQUESTED THIS TIME. Inquiries Direct inquiries regarding Notice to: David A. Jett, Ph.D. Program Director, NIH CounterACT Research National Institutes Health, NINDS 6001 Executive Blvd. NSC, Room 2177, MSC 9527 Bethesda, MD 20892-9527 Telephone: 301-496-6035 Fax: 301-402-1501 jettd@ninds.nih.gov

Research Category: CounterACT Expiration Date: Friday, January 1, 2027 NOFO Number: NOT-NS-09-018 Release Date: Tuesday, September 22, 2009 Notice Type: NOT

Notice Intent Publish Program Announcement Countermeasures Against Chemical Threats CounterACT) Exploratory/Developmental Projects Translational Research R21) Notice Number: NOT-NS-09-018 Key Dates Release Date: September 22, 2009 Issued National Institute Neurological Disorders Stroke NINDS) http://www.ninds.nih.gov) Purpose nbsp; National Institute Neurological Disorders Stroke NINDS) intends issue Program Announcement Special Referral Considerations PAR) the fall 2009 provide support exploratory developmental translational research therapeutics reducing mortality morbidity caused acute exposures chemical threat agents.  Chemical threat agents toxic chemicals could released a deliberate terrorist attack against civilians, by accident natural disaster causing mass casualties.  NIH CounterACT Research Program supports basic, translational, clinical research aimed the discovery and/or identification better therapeutic medical countermeasures against chemical threat agents, facilitates movement through regulatory process www.ninds.nih.gov/counteract).  CounterACT Exploratory/Developmental Projects Translational Research R21) be utilized support 1-2 year pilot studies generate tools proof-of-principle data therapeutics treat exposures chemical threats.  Chemical threats include traditional chemical warfare nerve agents such sarin VX, toxic industrial chemicals such cyanide chlorine, toxic agricultural chemicals such parathion sodium fluoroacetate.  Pilot studies include creation validation screening assays therapy development, identification candidate therapeutics, development preliminary proof-of-principle data the efficacy candidate therapeutics.  Four six awards anticipated, with direct costs limit 250,000 per year.  is anticipated several NIH Institutes, including National Eye Institute NEI), National Institute Allergy Infectious Diseases NIAID), National Institute Arthritis Musculoskeletal Skin Diseases NIAMS), Eunice Kennedy Shriver National Institute Child Health Human Development NICHD), National Institute Environmental Health Sciences NIEHS), the National Institute General Medical Sciences NIGMS), also participate this funding opportunity announcement. notice being provided allow potential applicants sufficient time develop responsive projects.  APPLICATIONS NOT BEING REQUESTED THIS TIME. Inquiries Direct inquiries regarding Notice to: David A. Jett, Ph.D. Program Director, NIH CounterACT Research National Institutes Health, NINDS 6001 Executive Blvd. NSC, Room 2177, MSC 9527 Bethesda, MD 20892-9527 Telephone: 301-496-6035 Fax: 301-402-1501 jettd@ninds.nih.gov

Research Category: CounterACT Expiration Date: Friday, January 1, 2027 NOFO Number: NOT-NS-08-007 Release Date: Wednesday, November 7, 2007 Notice Type: NOT
Research Category: CounterACT Expiration Date: Friday, January 1, 2027 NOFO Number: NOT-NS-07-015 Release Date: Tuesday, August 14, 2007 Notice Type: NOT
Research Category: CounterACT Expiration Date: Friday, January 1, 2027 NOFO Number: NOT-NS-06-006 Release Date: Monday, March 27, 2006 Notice Type: NOT
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