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Pre-Application Meeting RFA-DA-13-003: Tobacco Centers Regulatory Science Research Relevant the Family Smoking Prevention Tobacco Control Act Notice Number: NOT-DA-12-018 Key Dates Release Date: August 1, 2012 Related Notices RFA-DA-13-003 Issued National Cancer Institute NCI) National Heart, Lung, Blood Institute NHLBI) National Institute Alcohol Abuse Alcoholism NIAAA) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) Center Tobacco Products CTP) FDA) Purpose notice to inform potential applicants a pre-application web-based seminar RFA-DA-13-003, which prospective applicants invited. webinar intended explain goals objectives this initiative answer questions prospective applicants. Meeting Details Title: Pre-application meeting RFA-DA-13-003 When: Thursday, August 23, 2012, 3:00–4:30 PM Time Zone: GMT - 05:00) Eastern Time US Canada) Information the webinar be found this web site: http://cancercontrol.cancer.gov/nih-fda/funding.htm.  Instructions be provided how join web-based meeting, well participation guidelines the meeting agenda. Frequently Asked Questions submitted potential applicants also posted this website. Questions be submitted advance the following email:  NIHFDATobaccoScience@mail.nih.gov.  deadline submission questions Monday, August 20th, 5:00 p.m. Eastern Time.  While effort be to include questions the webinar presentations discussion, is possible not will addressed during meeting due time constraints. Potential applicants the FOA not required attend pre-application meeting. archive the meeting be posted http://cancercontrol.cancer.gov/nih-fda/funding.htm a public resource soon possible after meeting, provide applicants unable attend meeting access the proceedings. applicants strongly encouraged discuss applications the appropriate NIH IC Scientific/Research Contact and/or Financial/Grants Management Contact listed the FOA early possible the process.  complete text the FOA available at: http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-13-003.html. Inquiries Inquiries be directed to: Kay Wanke, PhD, MPH Epidemiology Research Branch Division Epidemiology, Services Prevention Research National Institute Drug Abuse NIDA) 301) 402-0036 Direct) 301) 443-6504 Main) 301) 443-2636 Fax) Email: kay.wanke@nih.gov Elizabeth M. Ginexi, PhD Tobacco Control Research Branch Division Cancer Control Population Sciences National Cancer Institute NCI) 301) 435-6387 Direct) 301) 496-8675 Fax) Email: LGinexi@mail.nih.gov Antonello Punturieri, M.D., Ph.D. Program Director Division Lung Diseases National Heart, Lung, Blood Institute NHLBI) 2 Rockledge Centre Suite 10018 6701 Rockledge Drive Bethesda, MD 20892 301) 435-0230 Direct) 301) 480-3557 Fax) Email: punturieria@nhlbi.nih.gov Abraham P. Bautista, Ph.D. Office Extramural Activities National Institute Alcohol Abuse Alcoholism NIAAA) 301) 443-9737 Alt 3013663942 Fax 3014436077 Email:bautista@mail.nih.gov Caroline Signore, MD, MPH Pregnancy Perinatology Branch Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) 301) 496-5577 Direct) 301) 496-5575 Main) 301) 496-3790 Fax) Email: signorec@mail.nih.gov Srikanth S Nadadur, M.Sc., Ph.D. Cellular, Organs Systems Pathobiology Branch Division Extramural Research Training National Institute Environmental Health Sciences NIEHS) 919) 541-5327 Direct) 919) 541-1919 Main) 919) 541-0462 Fax) Email: nadadurs@niehs.nih.gov Amy Goldstein, PhD Child Adolescent Treatment Preventive Intervention Research Branch National Institute Mental Health NIMH) 301) 496-7227 Direct) 301) 443-4045 Fax) Email: goldsteinam@mail.nih.gov Randall R. Stewart, Ph.D. Division Extramural Research National Institute Neurological Disorders Stroke NINDS) 301) 496-6460 Direct) 301) 496-1917 Main) 301) 402-1501 Fax) Email: stewartr@ninds.nih.gov

Sharing Data via Federal Interagency Traumatic Brain Injury Research FITBIR) Informatics System Notice Number: NOT-NS-12-016 Update: following update relating this announcement been issued: NOT-NS-17-029 March 27, 2014 - Notice NOT-NS-14-022. Notice Modification the Data Sharing Policy the Federal Interagency Traumatic Brain Injury Research FITBIR) Informatics System. March 21, 2013 - Notice NOT-NS-13-018. Notice Modification the Data Sharing Policy the Federal Interagency Traumatic Brain Injury Research FITBIR) Informatics System. Key Dates Release Date: June 4, 2012   Issued National Institute Neurological Disorders Stroke NINDS) Purpose further accelerate pace discovery advance research, National Institutes Health NIH) the Department Defense DoD) collaborating develop Federal Interagency Traumatic Brain Injury Research FITBIR) Informatics System.  FITBIR Informatics System provide traumatic brain injury TBI) research community a common platform exchanging data, protocols, research-related information.  Moreover, architecture FITBIR supports federation other data resources. FITBIR begin accepting clinical data July 16, 2012 a variety phenotypic assessments, including image genomic data, a variety formats details, FITBIR, Contributing Data).  TBI researchers are collecting clinical phenotypic, genomic imaging data expected share data via FITBIR, to this national resource advance projects.  is expected all investigators regardless the size the budget their research projects, regardless the source support their TBI research, including investigators supported NIH grants awarded under focused funding opportunity announcements FOAs) those under parent mechanism FOAs (“unsolicited” applications). TBI researchers supported non-federal sources also encouraged utilize FITBIR Informatics System.  Inquiries Inquiries regarding notice be directed to: FITBIR Operations Team Email: FITBIR-ops@mail.nih.gov

Request Information RFI) the Development a Federal Interagency Traumatic Brain Injury Research FITBIR) Informatics System Notice Number: NOT-NS-12-017 Update: following update relating this announcement been issued: March 27, 2014 - Notice NOT-NS-14-022. Notice Modification the Data Sharing Policy the Federal Interagency Traumatic Brain Injury Research FITBIR) Informatics System. March 21, 2013 - Notice NOT-NS-13-018. Notice Modification the Data Sharing Policy the Federal Interagency Traumatic Brain Injury Research FITBIR) Informatics System. Key Dates Release Date: June 4, 2012 Response Date: June 30, 2012 Related Notices NOT-NS-12-016 Issued National Institute Neurological Disorders Stroke NINDS) Center Information Technology CIT) Purpose stated the recent Notice NOT-NS-12-016, National Institutes Health NIH), collaboration the Department Defense DoD), developing Federal Interagency Traumatic Brain Injury Research FITBIR) Informatics System further accelerate pace discovery advance research. FITBIR Informatics System provide traumatic brain injury TBI) research community a common platform exchanging data, protocols, research-related information.  goal this RFI to seek public comment considerations the development implementation the FITBIR Informatics System.  Information obtained via RFI help improve design policies the FITBIR Informatics System optimize utility productivity, overall value the scientific community the public health. Background TBI a major medical problem lacks sensitive, predictive diagnostic tools proven effective treatments.   Developing effective diagnostics treatments challenging because the heterogeneity TBI, spans ages, evolves over time, includes wide variety causes injury severities.  address challenges, FITBIR Informatics System aims provide high quality, highly granular contemporary data can accessed analyzed scientific experts.  FITBIR Informatics System enable central archiving data both prospective retrospective studies, thereby prevent data sets being lost off-line, long-term storage a multitude distributed databases institutions.  large, rich clinical data set is stored a secure, centralized database the potential address critical questions fundamental needs TBI diagnosis treatment. Functionality include storage, query, retrieval, off-site backup, optionally pre-processing, post-processing, collaboration between approved researchers federal agencies.  Sharing phenotypic, imaging, functional outcome, pathology, genomic data a central secure repository greatly accelerate ability researchers to: a) validate research results; b) pool standardized information improve statistical significance; c) analyze data collected others explore new hypotheses well the variability different treatment protocols, an effort improve TBI treatments all; d) sophisticated analysis tools gain better understanding risk mitigating factors outcome after TBI. Information Requested RFI invites input potential FITBIR users well the broader biomedical research community other interested parties the following other matters relating the FITBIR Informatics System:  1.  FITBIR Data Sharing Policies, including timelines uploading sharing data, requirements   for accessing data.    2.  Strategies incentives promoting collaboration use the FITBIR Informatics System. 3.  Issues regarding informed consent re-consent data sharing. 4.  Research priorities the FITBIR Informatics System. 5. Strategies tools increasing availability aggregate data publications the broad   TBI community, e.g. patients families, healthcare providers, policy makers, other stakeholders. Responses Responses due June 30, 2012 may directed to: FITBIR Operations Team Email: FITBIR-ops@mail.nih.gov Any personal identifiers e.g., names, addresses, email addresses, etc.) be removed responses compiled.  Proprietary, classified, confidential, sensitive information should be included your response. Replies individual topics optional, anonymous responses permitted.  information provided be analyzed may appear various reports. Request Information RFI) for planning purposes only is a solicitation applications an obligation the part the United States U.S.) Government provide support any ideas identified response it.  Please note the U.S. Government not pay the preparation any comment submitted for use that comment. Inquiries further information contact: FITBIR Operations Team Email: FITBIR-ops@mail.nih.gov

Introduction the NeuroNEXT Network New Academic Investigators Disease Study Groups Notice Number:  NOT-NS-12-019 Key Dates Release Date:   June 4, 2012 Issued National Institute Neurological Disorders Stroke NINDS) Purpose Network Excellence Neuroscience Clinical Trials NeuroNEXT) designed increase efficiency clinical trials, facilitate patient recruitment retention, increase quality neuroscience clinical trials, to enable public-private partnerships. network includes multiple Clinical Sites, Clinical Coordinating Center CCC), one Data Coordinating Center DCC); listing the sites more information the network be found the NeuroNEXT website www.neuronext.org). clinical research network provide robust, standardized, accessible infrastructure facilitate rapid development implementation protocols neurological disorders affecting adult and/or pediatric populations. webinar intended introduce new Academic Investigators existing Neurological Disease Study Groups the NeuroNEXT network. will give overview the network including scope, purpose available resources. Discussions opportunities disease study groups apply collaborate NeuroNEXT occur. application process NeuroNEXT be explained. Time be allotted questions answers. Thursday, August 2, 2012 1:00 PM – 2:00 PM EST) Teleconference number toll-free: 1-877-739-5903 Access Code: 669-891-429 Audio PIN: Shown after joining Webinar Weblink:  Reserve Webinar seat at https://www1.gotomeeting.com/register/306886344 Title:    Introduction the NeuroNEXT Network New Academic Investigators Disease Study Groups Date:    Thursday. August 2, 2012 Time:   1:00 PM - 2:00 PM EST After registering will receive confirmation email containing information joining Webinar. Inquiries Please direct inquiries to: D. Elizabeth McNeil, MD MSc NINDS Telephone: 301-496-9135 mcneilde@ninds.nih.gov www.ninds.nih.gov/NeuroNEXT

Notice Changes Key Dates PAR-11-030, quot;Limited Competition: Brain Disorders the Developing World: Research across Lifespan R01)" Notice Number: NOT-TW-12-014 Key Dates Release Date: 30, 2012 Issued Fogarty International Center FIC) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) Office Dietary Supplements ODS) Purpose Notice being provided alert grantees the change Key Dates Non-AIDS related applications being submitted response the Funding Opportunity Announcement FOA), PAR-11-030 issued the Fogarty International Center FIC), invites applications the Limited Competition: Brain Disorders the Developing World: Research Across Lifespan R01) Program. nbsp;The changes the Key Dates for non-AIDS related applications only appear follows bold text: _____________________________________________________________________________ CURRENT LANGUAGE: Key Dates:  Letter Intent Receipt Date(s): Non-AIDS Related Applications: nbsp;December 10, 2012 AIDS Related Applications: March 11, 2013 Application Due Date(s): Non-AIDS Related Applications: January 10, 2013 AIDS Related Applications: April 11, 2013 Peer Review Date(s): June/July 2013 Council Review Date(s): October 2013 Early Anticipated Start Date(s): December 2013 Expiration Date: April 12, 2013 _______________________________________________________________________________ NEW LANGUAGE: Key Dates:  Letter Intent Receipt Date(s): Non-AIDS Related Applications: January 14, 2013 AIDS Related Applications: March 11, 2013 Application Due Date(s): Non-AIDS Related Applications: February 14, 2013 AIDS Related Applications: April 11, 2013 Peer Review Date(s): June/July 2013 Council Review Date(s): October 2013 Early Anticipated Start Date(s): December 2013 Expiration Date: April 12, 2013 other aspects the FOA remain unchanged. Inquiries Please direct inquiries to:   Kathleen Michels, Ph.D. Program Officer Division International Training Research Fogarty International Center FIC) National Institutes Health Building 31, Room B2C39 31 Center Drive, MSC 2220 Bethesda, MD 20892-2220 Telephone: 301-496-1653 Fax: 301-402-0779 Email: brainfic@nih.gov

Notice Changes Key Dates PAR-11-031, quot;Brain Disorders the Developing World: Research across Lifespan R21)" Notice Number: NOT-TW-12-015 Key Dates Release Date: 30, 2012   Issued Fogarty International Center FIC) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) Office Dietary Supplements ODS) Purpose Notice being provided alert grantees the change Key Dates Non-AIDS related applications being submitted response the Funding Opportunity Announcement FOA), PAR-11-031 issued the Fogarty International Center FIC), invites applications the Brain Disorders the Developing World: Research Across Lifespan R21) Program. nbsp;The changes the Key Dates for non-AIDS related applications only appear follows bold text: _____________________________________________________________________________ CURRENT LANGUAGE: Key Dates:  Letter Intent Receipt Date(s): Non-AIDS Related Applications: December 10, 2012 AIDS Related Applications: March 11, 2013 Application Due Date(s): Non-AIDS Related Applications: January 10, 2013 AIDS Related Applications: April 11, 2013 Peer Review Date(s): June/July 2013 Council Review Date(s): October 2013 Early Anticipated Start Date(s): December 2013 Expiration Date: April 12, 2013 _________________________________________________________________________________ NEW LANGUAGE: Key Dates:  Letter Intent Receipt Date(s): Non-AIDS Related Applications: nbsp;January 14, 2013 AIDS Related Applications: nbsp;March 11, 2013 Application Due Date(s): Non-AIDS Related Applications: February 14, 2013 AIDS Related Applications:  April 11, 2013 Peer Review Date(s): June/July 2013 Council Review Date(s): October 2013 Early Anticipated Start Date(s): December 2013 Expiration Date: April 12, 2013 other aspects the FOA remain unchanged. Inquiries Please direct inquiries to:   Kathleen Michels, Ph.D. Program Officer Division International Training Research Fogarty International Center FIC) National Institutes Health Building 31, Room B2C39 31 Center Drive, MSC 2220 Bethesda, MD 20892-2220 Telephone: 301-496-1653 Fax: 301-402-0779 Email: brainfic@nih.gov

Notice Changes Key Dates PAR-10-257, Chronic, Non-Communicable Diseases Disorders Across Lifespan: Fogarty International Research Training Award NCD-LIFESPAN) D43) Notice Number: NOT-TW-12-012 Key Dates Release Date: 24, 2012 Issued Fogarty International Center FIC) National Cancer Institute NCI) National Institute Aging NIA) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) Office Dietary Supplements ODS Purpose Notice being provided alert grantees the change Key Dates applications being submitted response the Funding Opportunity Announcement FOA), PAR-10-257 issued the Fogarty International Center FIC), invites applications the Chronic, Non-Communicable Diseases Disorders Across Lifespan: Fogarty International Research Training Award NCD-LIFESPAN) D43) Program. changes Key Dates appear follows bold text: CURRENT LANGUAGE: Key Dates: Letter Intent Receipt Date(s): August 21, 2012 Application Receipt Date(s): September 21, 2012 Peer Review Date(s): February/March 2013 Council Review Date(s): 2013 Earliest Anticipated Start Date(s): July 2013 Expiration Date: September 22, 2012 NEW LANGUAGE: Key Dates: Letter Intent Receipt Date(s): March 17, 2013 Application Receipt Date(s): April 17, 2013 Peer Review Date(s): October/November 2013 Council Review Date(s): January 2014 Earliest Anticipated Start Date(s): March 2014 Expiration Date: April 18, 2013 PLEASE NOTE: APPLICATIONS BE ACCEPTED THE ORIGINAL RECEIPT DATE SEPTEMBER 21, 2012. Applications only accepted the new receipt date April 17, 2013. other aspects the FOA remain unchanged. Inquiries Please direct inquiries to: nbsp; Kathleen Michels, Ph.D. Program Officer Division International Training Research Fogarty International Center FIC) National Institutes Health Building 31, Room B2C39 31 Center Drive, MSC 2220 Bethesda, MD 20892-2220 Telephone: 301-496-1653 Fax: 301-402-0779 Email: FIC-NCD-D43@nih.gov

Change NINDS salary caps the K02, K08 K23 Career Development Awards Notice Number:  NOT-NS-12-018 Key Dates Release Date: 18, 2012 Related Notices PA-11-193 PA-11-194 PA-11-191 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to inform community the NINDS salary caps change 95,000 K08 K23 awards, to 105,000 the K02 award. other budgetary items policies NINDS Career Development Awards remain identical, including policies 1) outlined NOT-NS-09-015 regarding Mentored Career Development Award salary structure 2) regarding NINDS K02 award salary structure the K awardee obtains NIH R01 during 5 year K award period. change effective immediately all competing awards associated the May, 2012 council round thereafter. awards before May, 2012, change become effective the next anniversary date the award the non-competing award made. Inquiries Please direct inquiries to: Stephen Korn, Ph.D. Director Office Training, Career Development Workforce Diversity National Institute Neurological Disorders Stroke NINDS) National Institutes Health Email: korns@ninds.nih.gov 

Notice Change Country Eligibility Fogarty International Training Grants Notice Number: NOT-TW-12-011 Key Dates Release Date:   May 11, 2012 Related Announcements NOT-TW-17-002 PAR-16-407 RFA-TW-16-002 PAR-16-082 RFA-TW-16-001 PAR-16-045 PAR-15-292 PAR-16-279 PAR-16-281 Issued Fogarty International Center FIC) National Cancer Institute NCI) National Institute Aging NIA) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) Office Dietary Supplements ODS) Purpose Background Intent: Fogarty International Center FIC) historically limited eligibility research training grants institutions low- middle-income countries LMICs), defined the World Bank http://data.worldbank.org/about/country-classifications/country-and-len…).  the rapid growth research training opportunities funded national governments emerging economies around world, broad categorization today become less meaningful the context FIC’s biomedical research capacity-building goals.  particular, countries the Upper Middle Income Country UMIC) bracket today large growing national research training programs fellowship opportunities their own.   a result, FIC revising eligibility criteria our research training programs a subset these nations, such their participation consistent the traditional eligibility rules Upper Income Country Institutions.  is, may participate training partners, may receive support their own trainees.  Specific Change: Beginning receipt dates after January 1, 2013, following change eligibility take effect competing re-competing research training grant applications D43, D71, U2R mechanisms) FIC. the exception Sub-Saharan African countries, FIC no longer accept research training applications from, research training applications involve training scientists UMICs are also members the G20 major economies http://www.g20.org/en/members).    Based the classifications above, change currently applies the following countries: Argentina, Brazil, China, Mexico, Russia, Turkey, the Upper Middle Income European Union member countries Bulgaria, Latvia, Lithuania, Romania.  list change over time countries change categories within classifications. change does preclude involvement G20 UMIC countries partners FIC research training programs where goal to train scientists eligible LMICs to build research capacity the LMIC institutions.  change not apply a D43 application submitted follow to successful planning grant application had received prior January 1, 2013.  change does affect eligibility FIC Research grant programs generally R U mechanisms).  Neither does change affect eligibility rules any grant any component the National Institutes Health.   Finally, does preclude UMIC G20 country trainees eligibility FIC research training programs their participation specifically outlined a bi-lateral agreement between FIC international partner funding organizations cooperative funding such activities. Such agreements be identified specifically relevant funding opportunity announcements. Inquiries Please direct inquiries to: Dr. Joshua Rosenthal, Ph.D. Acting Deputy Director Office the Director Fogarty International Center National Institutes Health Email: FICENQ@mail.nih.gov   Website FAQS: http://www.fic.nih.gov/Grants/Pages/country-eligibility.aspx

NINDS Request Information Stroke Research Priorities Notice Number:  NOT-NS-12-009 Key Dates Release Date: 9, 2012 Response Due Date: June 30, 2012   Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this time-sensitive Request Information RFI) to seek input the broad stroke research community the most important needs promising opportunities the advancement stroke research.  RFI part a larger community-based stroke research planning effort, has involved comprehensive review research advances new unmet needs have emerged over last five years, which lead the development a focused set recommendations overarching stroke research priorities be addressed over next 5 - 10 years. Background: mission the National Institute Neurological Disorders Stroke NINDS) to reduce burden neurological disease.  NINDS accomplishes mission advancing basic, translational clinical research all the diseases under purview that important discoveries be applied improve public health.  facilitate continued advancement stroke research all levels basic discovery treatment development clinical application, NINDS leading stroke research planning effort order identify most promising opportunities the field over next 5 – 10 years.  Representing first stage this planning effort, Stroke Progress Review Group SPRG) completed final review recent stroke research advances identified new unmet needs moving forward each 16 different research subtopics. SPRG been valuable resource the community during past decade, providing first comprehensive assessment 2001 an interim report 2006, most recently final report will continue guide research efforts the coming years.  the current fiscally challenging budget climate, however, is important identify opportunities which significant, community-based effort focus lead major advances stroke research across continuum prevention treatment rehabilitation. Therefore, second phase this planning effort involve discussion among wide range stakeholders help Institute develop focused set priorities the stroke research community NINDS address together over next 5-10 years. Information requested: RFI invites input priorities the stroke research community address over next 5-10 years.  priorities should represent cross-cutting research opportunities have high probability leading a major advance our biologic understanding treatment the disease.  Identify provide input up three high priority stroke research efforts if completed over next 5-10 years lead major advances stroke science. are interested basic, translational, and/or clinical research areas well approaches cut across areas. Please note you not need be stroke specialist respond, we welcome input related disciplines.  input be used the planning panel during consideration the research priorities.  each topic submitted, please comment these five elements: a) Description – challenge, opportunity research question the stroke field address, indicate relevance one more the following three areas:  prevention, acute treatment, recovery rehabilitation.  b) Rationale – background scientific evidence forms basis this research topic/question. c) Readiness – Whether opportunity challenge primed action and the expected deliverables be after 5-10 year effort considering strategic advantages the current state the science, infrastructure capacity, new technologies, new discoveries, etc.), if is newer area science needs be further developed because its great potential high scientific payoff the future i.e. high risk/high reward, longer time frame). d) Impact -- immediate long-term impacts accomplishment this area answering stroke research question have the science on public health.  can include justifying why is national stroke research priority. e) Approach -- Potential approach study design pursue scientific opportunity team science, centers excellence, science challenge, prospective randomized trial, epidemiologic study, prospective data collection without randomization, etc.). Include in research community need become engaged, whether existing infrastructure research capacity sufficient would need be developed.  Also indicate any barriers need be overcome allow area move forward suggest strategies addressing them. General information: Note: of following fields optional.  Proprietary, classified, confidential, sensitive information should be included your response.  1. Please identify nature your interest stroke research i.e. you biomedical clinical researcher, member an advocacy community group, interested member the public, other?). 2. you an investigator, please indicate career level main area research interest, including whether focus clinical basic research. 3. you a member a particular advocacy professional organization, please indicate name primary focus the organization i.e. research support, patient care, etc.) whether are responding behalf your organization not, please indicate position within organization). 4. Please provide name email address. Responses: assure consideration, responses must received June 30, 2012. Responses this RFI must submitted electronically using web-based format http://www.ninds.nih.gov/strokerfi. Responses this RFI voluntary. comments collected be analyzed considered planning development future initiatives.  Any personal identifiers be removed responses compiled.  Proprietary, classified, confidential, sensitive information should be included your response.  Request Information RFI) for planning purposes only is a solicitation applications an obligation the part the United States U.S.) Government provide support any ideas identified response it.  Please note the U.S. Government not pay the preparation any comment submitted for use that comment. Inquiries Please direct inquiries to: Katie Pahigiannis, Ph.D. NINDS Office Science Policy Planning National Institutes Health Phone: 301-496-9172 katie.pahigiannis@nih.gov