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Notice Intent Publish Funding Opportunity Announcement Data Coordinating Center the NINDS Stroke Trials Network U01) Notice Number: NOT-NS-13-009 Key Dates Release Date:  February 1, 2013 Estimated Publication Date Announcement: June 1, 2013 First Estimated Application Due Date: September 1, 2013 Earliest Estimated Award Date: April 1, 2014 Earliest Estimated Start Date: April 1, 2014 Related Announcements NOT-NS-13-007 NOT-NS-13-008 Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS) intends issue Funding Opportunity Announcement FOA) solicit applications a Clinical Coordinating Center the NINDS Stroke Trials Network U01)”. goal this initiative to harness multidisciplinary stroke expertise work together an efficient manner conduct exploratory NINDS-sponsored phase 2 clinical trials the treatment stroke the goal quickly move potential treatments larger, confirmatory phase 3 trials.  initiative provide support develop, promote conduct high quality, multi-site clinical trials stroke focused key interventions prevention, treatment, recovery the objective have balanced portfolio between three approaches.  Exploratory phase 2 confirmatory phase 3 clinical trials well biomarker-validation studies are immediately preparatory trials be coordinated through separate Data Clinical Coordinating Centers DCC CCC).  Efficiency be encouraged through use master trial agreements a central IRB.  Leaders drawn both clinical basic stroke science communities the sites contribute the development network clinical trial applications peer review, well planning execution applications coming outside the network, including trials result a Collaborative Research Development Agreement CRADA) between NINDS an Industry partner.  Network also uniquely poised rapidly collaborate other existing networks, such the NINDS Neurological Treatment Trials Network NETT), International Consortia conduct larger, definitive trials promising interventions the treatment stroke. http://www.ninds.nih.gov/find_people/ninds/OSPP/Stroke-Research-Priorit… a description the Stroke Priorities this network.  Notice being provided allow potential applicants sufficient time develop meaningful collaborations competitive research programs.  FOA expected be published Spring 2013 an expected application due date September 2013. FOA utilize U01 activity code. Details the planned FOA provided below. Research Initiative Details NINDS Stroke Trials Network utilize Cooperative Agreements U01) support Data Coordinating Center the Stroke Trials Network up 5 years.  Statistical Data Coordinating Center DCC) support protocol data management, data quality control including data monitoring), undertake interim monitoring, analyses reporting the Clinical Coordinating Center, NINDS, Data Safety Monitoring Boards DSMBs).  DCC also initiate coordinate activities promote standardization data elements using NINDS Stroke common data elements support aggressive sharing policy de-identified data. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Scott Janis, Ph.D. Program Director Office Clinical Research National Institute Neurological Disorders Stroke Room 2170, MSC 9525 6001 Executive Blvd. Bethesda, MD 20892-9525 Telephone: 301) 496-9135 Fax: 301) 410-1080 Email: janiss@ninds.nih.gov Website: http://www.ninds.nih.gov/find_people/ninds/bio_scott_janis.htm

Notice Intent Publish Reissuance PA-10-006 Mechanisms, Models, Measurement, & Management Pain Research R01)" Notice Number:  NOT-NR-13-007 Key Dates Release Date: January 25, 2013 Estimated Publication Date Announcement: March 5, 2013   First Estimated Application Due Date: June 5, 2013  Earliest Estimated Award Date: September 15, 2013 Earliest Estimated Start Date: September 15, 2013 Related Announcements PA-10-006 NOT-NR-13-008 NOT-NR-13-009 Issued National Institute Nursing Research NINR) National Cancer Institute NCI) National Institute Aging NIA) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Dental Craniofacial Research NIDCR) National Institute Diabetes Digestive Kidney Diseases NIDDK) National Institute Drug Abuse NIDA) National Institute General Medical Sciences NIGMS) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Alternative Medicine NCCAM) Purpose National Institute Nursing Research, along the National Cancer Institute NCI), National Institute Aging NIA), National Institute Arthritis Musculoskeletal Skin Diseases NIAMS), Eunice Kennedy Shriver National Institute Child Health Human Development NICHD), National Institute Dental Craniofacial Research NIDCR), National Institute Diabetes Digestive Kidney Diseases NIDDK), National Institute Drug Abuse NIDA), National Institute General Medical Sciences NIGMS), National Institute Neurological Disorders Stroke NINDS), the National Center Complementary Alternative Medicine NCCAM), informs community the following FOA its companions be reissued: PA-10-006  "Mechanisms, Models, Measurement, & Management Pain Research R01)" Notice being provided allow potential applicants sufficient time develop meaningful collaborations appropriate projects.  FOA be published Spring 2013. FOA continue utilize R01 Research Project Grant mechanism. Research Initiative Details Notice encourages investigators expertise insights this area Mechanisms, Models, Measurement, & Management Pain consider applying this FOA. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Dr. Susan Marden, PhD Program Director, Office Extramural Activities National Institute Nursing Research, NIH 6701 Democracy Blvd., Suite 710 Democracy Plaza Bethesda, MD 20892-4870 Telephone: 301) 496-9623 Fax: 301) 480-8260 Email: mardens@mail.nih.gov

Notice Intent Publish Reissuance PA-10-008  "Mechanisms, Models, Measurement, & Management Pain Research R03)" Notice Number:  NOT-NR-13-008 Key Dates Release Date: January 25, 2013 Estimated Publication Date Announcement: March 5, 2013   First Estimated Application Due Date: June 16, 2013  Earliest Estimated Award Date: September 15, 2013 Earliest Estimated Start Date: September 15, 2013 Related Announcements PA-10-008 NOT-NR-13-007 NOT-NR-13-009 Issued National Institute Nursing Research NINR) National Cancer Institute NCI) National Institute Aging NIA) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Dental Craniofacial Research NIDCR) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Nursing Research, along the National Cancer Institute NCI), National Institute Aging NIA), Eunice Kennedy Shriver National Institute Child Health Human Development NICHD), National Institute Dental Craniofacial Research NIDCR), National Institute Drug Abuse NIDA), National Institute Neurological Disorders Stroke NINDS),  informs community the following FOA its companions be reissued: PA-10-008  "Mechanisms, Models, Measurement, & Management Pain Research R03)"   Notice being provided allow potential applicants sufficient time develop meaningful collaborations appropriate projects.  FOA be published Spring 2013. FOA continue utilize R03 Small Grant mechanism. Research Initiative Details Notice encourages investigators expertise insights this area Mechanisms, Models, Measurement, & Management Pain consider applying this FOA. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Dr. Susan Marden, PhD Program Director, Office Extramural Activities National Institute Nursing Research, NIH 6701 Democracy Blvd., Suite 710 Democracy Plaza Bethesda, MD 20892-4870 Telephone: 301) 496-9623 Fax: 301) 480-8260 Email: mardens@mail.nih.gov

Notice Intent Publish Reissuance PA-10-007 Mechanisms, Models, Measurement, & Management Pain Research R21)" Notice Number:  NOT-NR-13-009 Key Dates Release Date: January 25, 2013 Estimated Publication Date Announcement: March 5, 2013   First Estimated Application Due Date: June 16, 2013  Earliest Estimated Award Date: September 15, 2013 Earliest Estimated Start Date: September 15, 2013 Related Announcements PA-10-007 NOT-NR-13-007 NOT-NR-13-008 Issued National Institute Nursing Research NINR) National Cancer Institute NCI) National Institute Aging NIA) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Dental Craniofacial Research NIDCR) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Nursing Research, along the National Cancer Institute NCI), National Institute Aging NIA), National Institute Arthritis Musculoskeletal Skin Diseases NIAMS), Eunice Kennedy Shriver National Institute Child Health Human Development NICHD), National Institute Dental Craniofacial Research NIDCR), National Institute Drug Abuse NIDA), National Institute Neurological Disorders Stroke NINDS), informs community the following PA its companions be reissued: PA-10-007 Mechanisms, Models, Measurement, & Management Pain Research R21) Notice being provided allow potential applicants sufficient time develop meaningful collaborations appropriate projects.  FOA be published Spring 2013. FOA continue utilize R21 NIH Exploratory/Developmental Research Grant mechanism. Research Initiative Details Notice encourages investigators expertise insights this area Mechanisms, Models, Measurement, & Management Pain consider applying this FOA. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Dr. Susan Marden, PhD Program Director, Office Extramural Activities National Institute Nursing Research, NIH 6701 Democracy Blvd., Suite 710 Democracy Plaza Bethesda, MD 20892-4870 Telephone: 301) 496-9623 Fax: 301) 480-8260 Email: mardens@mail.nih.gov

Technical Assistance the Development High Throughput Screening HTS) Assay Notice Number: NOT-MH-13-011 Key Dates Release Date: January 16, 2013 Related Announcements PAR-12-058 PAR-12-059 Issued National Institute Mental Health NIMH) National Cancer Institute NCI) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Diabetes Digestive Kidney Diseases NIDDK) National Institute Drug Abuse NIDA) National Institute General Medical Sciences NIGMS) National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to facilitate access researchers a screening laboratory develop High Throughput Screening HTS) assay thereby submit grant application PAR-12-058 R01) PAR-12-059 R21). HTS Assay Development Assistance screening laboratory e.g., Academic Screening Facilities Directory, http://www.slas.org/screeningFacilities/facilityList.cfm) provide advice such identification selection commercial HTS assay reagents, suitable HTS assay format readout. addition, screening laboratory be able provide assistance adapting assays an HTS format e.g., 1536-well 384-well microplate) performing pilot screen a small library compounds e.g., Library Pharmacologically Active Compounds LOPAC) collection, NIH Clinical Collection, etc.) generate sufficient preliminary assay data support grant application submission. Further, researchers might seek advice the screening laboratory orthogonal assays validate screening hits, advice chemical improvement the initial hits via structure-activity relationship SAR) study. technical resources HTS assay development include online comprehensive guidebook Assay Guidance Manual http://www.ncbi.nlm.nih.gov/books/NBK53196/), HTS assay protocols deposited PubChem BioAssay data base http://www.ncbi.nlm.nih.gov/sites/entrez?db=pcassay), ASSAY Drug Development Technologies, peer-reviewed bimonthly journal, the Journal Biomolecular Screening. Inquiries Inquiries regarding Notice be directed to: Yong Yao, Ph.D. National Institute Mental Health NIMH) Telephone: nbsp;(301) 443-6102 Email: nbsp;yyao@mail.nih.gov

Notice Intent Publish Funding Opportunity Announcement Countermeasures Against Chemical Threats CounterACT) Cooperative Research Projects U01) Notice Number: NOT-NS-13-004 Key Dates Release Date: December 20, 2012 Estimated Publication Date Announcement: 1, 2013  First Estimated Application Due Date: September 16, 2013   Earliest Estimated Award Date: July 1, 2014  Earliest Estimated Start Date: July 1, 2014 Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS), intends re-issue Program Announcement Special Review Considerations PAR) solicit applications ldquo;Countermeasures Against Chemical Threats CounterACT) Cooperative Research Projects U01)”. goal this initiative to provide support translational research develop therapeutics reducing mortality morbidity caused acute exposures chemical threat agents. Chemical threats toxic chemicals could used a terrorist attack accidentally released industrial production, storage shipping.  scope the research supported within milestone-driven translational program includes target candidate identification characterization, through candidate optimization demonstration in vivo efficacy, through Investigational New Drug IND) submission.   www.ninds.nih.gov/counteract a description the CounterACT program.  Notice being provided allow potential applicants sufficient time develop meaningful collaborations competitive research programs.  FOA expected be published Spring 2013 an expected application due date September 2013. FOA utilize U01 activity code. Details the planned FOA provided below. Research Initiative Details Notice encourages collaborative multidisciplinary investigations, combining expertise toxicology drug discovery development, discover develop new improved therapeutics treating victims chemical exposures. CounterACT research program utilize Research Project - Cooperative Agreements U01) support Research Projects up 5 years translational research.  research project must establish milestones include discrete quantitative goals create or no-go decision points the project.  Chemical threats be covered include chemical warfare agents e.g. sarin, VX), Toxic Industrial Chemicals e.g. phosgene, sulfur dioxide) others. Please contact NIH Program Director below discuss chemical threats be covered.  NIH intends commit approximately 2-3 million per year Fiscal Years 2014, 2015, 2016 fund new and/or competing renewal U01 awards.  Since nature scope the proposed research vary application application, is anticipated the size duration each award also vary. total amount awarded the number awards depend the number, quality, duration, costs the applications received.  is anticipated several NIH Institutes, including National Eye Institute NEI), National Institute Allergy Infectious Diseases NIAID), National Institute Arthritis Musculoskeletal Skin Diseases NIAMS), Eunice Kennedy Shriver National Institute Child Health Human Development NICHD), National Institute Environmental Health Sciences NIEHS), the National Institute General Medical Sciences NIGMS), also participate this funding opportunity announcement.  APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: David A. Jett, Ph.D. Program Director, NIH CounterACT Research National Institutes Health, NINDS 6001 Executive Blvd. NSC, Room 2177, MSC 9527 Bethesda, MD 20892-9527 Telephone: 301-496-6035 Fax: 301-402-1501 Email: jettd@ninds.nih.gov

Notice Intent Publish Funding Opportunity Announcement Countermeasures Against Chemical Threats CounterACT) Research Centers Excellence U54) Notice Number: NOT-NS-13-005 Key Dates Release Date: December 20, 2012 Estimated Publication Date Announcement: 1, 2013  First Estimated Application Due Date: September 16, 2013   Earliest Estimated Award Date: July 1, 2014  Earliest Estimated Start Date: July 1, 2014 Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS), intends re-issue Program Announcement Special Review Considerations PAR) solicit applications ldquo;Countermeasures Against Chemical Threats CounterACT) Research Centers Excellence U54)”. goal this initiative to provide support translational research develop therapeutics reducing mortality morbidity caused acute exposures chemical threat agents. Chemical threats toxic chemicals could used a terrorist attack accidentally released industrial production, storage shipping.  scope the research supported within milestone-driven translational program includes target candidate identification characterization, through candidate optimization demonstration in vivo efficacy, through Investigational New Drug IND) submission.  www.ninds.nih.gov/counteract a description the CounterACT program.  Notice being provided allow potential applicants sufficient time develop meaningful collaborations competitive research programs.  FOA expected be published Spring 2013 an expected receipt date September 2013. FOA utilize U54 activity code. Details the planned FOA provided below. Research Initiative Details Notice encourages collaborative multidisciplinary investigations, combining expertise toxicology drug discovery development, discover develop new improved therapeutics treating victims chemical exposures. CounterACT research program utilize Specialized Center Cooperative Agreements U54) support Research Centers Excellence up 5 years translational research.  Research Center must establish milestones include discrete quantitative goals create or no-go decision points the project.   Each Center include several individual research projects scientific administrative cores create interdisciplinary synergistic multifaceted research approach, centered a central common goal.  Chemical threats be covered include chemical warfare agents e.g. sarin, VX), Toxic Industrial Chemicals e.g. phosgene, sulfur dioxide) others.  Please contact NIH Program Director below discuss chemical threats be covered.    The NIH intends commit approximately 3-4 million per year Fiscal Years 2014, 2015, 2016 fund new and/or competing renewal U54 awards.  Since nature scope the proposed research vary application application, is anticipated the size duration each award also vary. total amount awarded the number awards depend the number, quality, duration, costs the applications received.  is anticipated several NIH Institutes, including National Eye Institute NEI), National Institute Allergy Infectious Diseases NIAID), National Institute Arthritis Musculoskeletal Skin Diseases NIAMS), Eunice Kennedy Shriver National Institute Child Health Human Development NICHD), National Institute Environmental Health Sciences NIEHS), the National Institute General Medical Sciences NIGMS), also participate this funding opportunity announcement.  APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: David A. Jett, Ph.D. Program Director, NIH CounterACT Research National Institutes Health, NINDS 6001 Executive Blvd. NSC, Room 2177, MSC 9527 Bethesda, MD 20892-9527 Telephone: 301-496-6035 Fax: 301-402-1501 Email: jettd@ninds.nih.gov

Notice Intent Publish Funding Opportunity Announcement FOA) Dissemination Implementation Research Health R01) Notice Number: NOT-MH-13-009 Key Dates Release Date: December 20, 2012 Estimated Publication Date Announcement: January 8, 2013  First Estimated Application Due Date: February 5, 20213  Earliest Estimated Award Date: September 2013  Earliest Estimated Start Date: September 2013  Related Announcements PAR-10-038 Issued National Institute Mental Health NIMH) National Cancer Institute NCI) National Center Complementary Alternative Medicine NCCAM) National Heart, Lung, Blood Institute NHLBI) National Human Genome Research Institute NHGRI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Allergy Infectious Diseases NIAID) National Institute Deafness Other Communication Disorders NIDCD) National Institute Dental Craniofacial Research NIDCR) National Institute Diabetes Digestive Kidney Diseases NIDDK) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) Office Behavioral Social Sciences Research OBSSR) Purpose purpose this Notice to inform potential applicants the National Institute Mental Health, along the participating Institutes listed above, intends reissue PAR-10-038 quot;Dissemination Implementation Research Health R01)," the companion FOAs, will expire January 8, 2013. FOA utilize Research Project Grant R01) activity code. Details the planned FOA provided below. Research Initiative Details funding opportunity encourage research grant applications will identify, develop, evaluate refine effective efficient methods, systems, infrastructures, strategies disseminate implement research-tested health behavior change interventions, evidence-based prevention, early detection, diagnostic, treatment management, quality life improvement services, data monitoring surveillance reporting tools public health clinical practice settings focus patient outcomes. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Inquiries regarding Notice be directed to: David Chambers, D.Phil. National Institute Mental Health NIMH) Telephone: 301-443-3747 Email:  dchamber@mail.nih.gov

Request Information RFI): Curing Epilepsies 2013 - Updating Epilepsy Research Benchmarks Notice Number: NOT-NS-13-003 Key Dates Release Date: November 30, 2012 Responses due by: January 31, 2013 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Request Information RFI) to seek broad input the most important new ongoing challenges opportunities epilepsy research.  Background Since 2000, NINDS has worked the epilepsy community identify priorities research. 2000 2007, NINDS sponsored Curing Epilepsy conferences partnership nongovernmental organizations other Federal agencies assess state epilepsy research identify needs new directions. conferences led the development subsequent revision the Epilepsy Research Benchmarks, series goals research toward cures the epilepsies, defined no seizures, side effects, the prevention epilepsy those risk. 2007 Benchmarks encompass range basic, translational, clinical research priorities focused understanding causes epilepsy, identifying strategies preventing epileptogenesis, developing improving epilepsy treatments, understanding treating comorbid conditions affecting people epilepsy, understanding ultimately preventing sudden unexpected death epilepsy SUDEP).   Benchmarks meant engage entire epilepsy community advancing research, including NIH, NIH grantees other researchers, epilepsy professional organizations, the epilepsy patient community. NINDS particular considers Benchmarks planning new investments epilepsy research has also worked epilepsy researchers serve Benchmarks Stewards track promote progress.  April 17-19, 2013, NINDS sponsor third public conference, quot;Curing Epilepsies 2013: Pathways Forward," reassess state epilepsy research. conference include scientific sessions major topics the field will culminate a discussion possible updates the Epilepsy Research Benchmarks. help inform discussions, Epilepsy Benchmarks Stewards prepared progress report summarizing research advances since 2007, well their views opportunities challenges future research. progress report available the NINDS website at: http://www.ninds.nih.gov/research/epilepsyweb/benchmarks_2007-2012progr…. Information Requested request information intended provide broader perspective progress in epilepsy research on scientific opportunities the years come. NINDS invites input epilepsy researchers academia industry, healthcare professionals, patient advocates advocacy organizations, scientific professional organizations, Federal agencies, other interested members the public. Organizations strongly encouraged submit single response reflects views the organization a whole. Please provide perspectives the following topics.               most important advances basic, translational, clinical epilepsy research since 2007. New ongoing challenges opportunities epilepsy research. role Epilepsy Research Benchmarks played, could play, terms promoting awareness shared priorities stimulating progress. to Submit Response assure consideration, responses must received January 31, 2013, should submitted electronically using web-based form www.ninds.nih.gov/2013epilepsiesRFI. web form provide confirmation response submission, respondents not receive individualized feedback. Responses this RFI voluntary may submitted anonymously.  Please not include any personally identifiable other information you not wish make public.  Proprietary, classified, confidential, sensitive information should be included your response.  Comments submitted be compiled discussion the upcoming conference, Curing Epilepsies 2013: Pathways Forward, may appear various reports.  Any personal identifiers personal names, email addresses, etc.) be removed responses compiled.  Request Information RFI) for informational planning purposes only is a solicitation applications an obligation the part the United States U.S.) Government provide support any ideas identified response it.  Please note the U.S. Government not pay the preparation any information submitted, for use that information. Inquiries Please direct inquiries to: Cara B. A. Long, Ph.D. Office Science Policy Planning National Institute Neurological Disorders Stroke National Institutes Health Phone: 301-496-9172 Email: cara.long@nih.gov

Clarification Budget Instructions RFA-HD-13-004 Centers Collaborative Research Fragile X U01) Notice Number: NOT-HD-12-034 Key Dates Release Date: November 16, 2012 Related Announcements RFA-HD-13-004 nbsp; Issued Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to clarify budget instructions RFA-HD-13-004 quot;Centers Collaborative Research Fragile X U01)". instructions budgets each Center up linked U01 awards) exceed 1.3 million TOTAL costs per year should read 1.3 million DIRECT costs per year. Section II. Award Information - Current Language Individual linked U01 application budgets should reflect actual needs the proposed projects.  Budgets each Center up linked U01 awards) not exceed 1.3 million total costs per year. Section II. Award Information - Revised Language Individual linked U01 application budgets should reflect actual needs the proposed projects.  Budgets each Center up linked U01 awards) not exceed 1.3 million direct costs per year. other aspects this FOA remain same.    Inquiries Please direct inquiries to: Tiina K. Urv, PhD Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) Telephone 301-402-7015 Email: urvtiin@mail.nih.gov