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Notice Expiration PAR-16-340 Career Transition Award NINDS Intramural Clinician-Scientists K22)" Notice Number: NOT-NS-18-035 Key Dates Release Date:   January 11, 2018 Related Announcements PAR-16-340 Issued National Institute Neurological Disorders Stroke NINDS) Purpose notice announces expiration PAR-16-340 quot;Career Transition Award NINDS Intramural Clinician-Scientists K22)" effective January 24, 2018. notice also serves inform applicants NINDS plans reissue Funding Opportunity Announcement FOA) compliance FORMS-E. nbsp; Part 1. Overview Key Dates Currently Reads: Application Due Date(s): Standard dates October 12, 2016; February 12, 2017; June 12, 2017; October 12, 2017; February 12, 2018; June 12, 2018; October 12, 2018; February 12, 2019; June 12, 2019) Modified Read: Application Due Date(s): Standard dates October 12, 2016; February 12, 2017; June 12, 2017; October 12, 2017) Currently Reads: Expiration Date: 8, 2019 Modified Read: Expiration Date: January 24, 2018 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Stephen Korn, Ph.D. National Institute Neurological Disorders Stroke Telephone: 301-496-4188 Email: korns@mail.nih.gov

Notice Expiration PAR-15-195 NeuroNEXT Infrastructure Resource Access X01)" Notice Number: NOT-NS-18-037 Key Dates Release Date: January 11, 2018 Related Announcements PAR-15-195 Issued National Institute Neurological Disorders Stroke NINDS) Purpose notice announces expiration PAR-15-195 quot;NeuroNEXT Infrastructure Resource Access X01)" effective January 24, 2018.  last date NINDS accept applications PAR-15-195 January 23, 2018. Part 1: Overview nbsp; Key Dates: Currently Reads: Application Due Date(s): Applications accepted continuous receipt. Council Round: Receipt Window: November 13 - March 12 Council Round: October Receipt Window: March 13 - July 12 Council Round: January Receipt Window: July 13 - November 12 5:00 PM local time applicant organization. types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Modified Read: Application Due Date(s): Applications accepted continuous receipt. Council Round: Receipt Window: November 13 - January 23, 2018 5:00 PM local time applicant organization. types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Currently Reads: Expiration Date: March 13, 2018 Modified Read: Expiration Date: January 24, 2018 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Codrin Lungu, MD National Institute Neurological Disorders amp; Stroke NINDS) Telephone: 301-496-9135 Email: mcneilde@ninds.nih.gov

NIH Applicant Assistance Program AAP) New Previously Unawarded Small Businesses Notice Number: NOT-CA-18-031 Key Dates Release Date: December 21, 2017 Related Announcements NOT-CA-18-072 Issued National Cancer Institute NCI) National Heart, Lung, Blood Institute NHLBI) National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to announce pilot program assist eligible small businesses understanding completing Small Business Innovation Research SBIR) Small Business Technology Transfer STTR) application process. program, NIH Applicant Assistance Program AAP), intended help new and/or previously unsuccessful small businesses submit competitive SBIR STTR application one the participating institutes NCI, NINDS, NHLBI). AAP designed to: Provide support small businesses preparing Phase SBIR STTR application Assist identifying appropriate market research an SBIR/STTR application Guide applicants through application process, including required registrations Help applicants the electronic system apply an SBIR/STTR award NIH particularly interested assisting small businesses are owned operated individuals are underrepresented the biomedical sciences, including: Black African Americans   Hispanics Latinos American Indians Alaska Natives Native Hawaiians other Pacific Islanders Individuals disabilities Women underrepresented biomedical industry ownership high-level leadership) service provided through third-party federal contractor. Small businesses must apply be accepted the NIH AAP. After acceptance, program offered no charge the small business. Participation this program optional does guarantee successful SBIR STTR award. Small businesses interested the program apply here: https://www.dawnbreaker.com/aap/ Inquiries Please direct inquiries to: Kory Hallett, PhD National Cancer Institute NCI) Telephone: 240-276-5882 Email: kory.hallett@nih.gov Stephanie Fertig, MBA National Institute Neurological Disorders Stroke NINDS) Telephone 301-496-1779 Email: fertigs@ninds.nih.gov Eric Padmore, MHSA National Heart, Lung, Blood Institute NHLBI) Telephone: 301-496-2149 Email: NHLBI_SBIR@mail.nih.gov

Notice NINDS Withdrawal Participation PA-18-286 Exploratory/Developmental Bioengineering Research Grants EBRG) R21 Clinical Trial Optional)" Notice Number: NOT-NS-18-030 Key Dates Release Date:   December 18, 2017 Related Announcements PA-18-286 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to inform applications as the February 16, 2018, standard due date, NINDS no longer participate the Exploratory/Developmental Bioengineering Research Grants EBRG) R21 Clinical Trial Optional) PA-18-286), will accept any applications  the Funding Opportunity Announcement FOA) PA18-286. Currently reads: Components Participating Organizations National Cancer Institute NCI) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) Catalog Federal Domestic Assistance CFDA) Number(s) 93.865; 93.853; 93.399; 93.396; 93.395; 93.394; 93.393; 93.279; 93.846 Part 2. Full Text Announcement Section I. Funding Opportunity Description IC Specific Guidelines following text been removed: NINDS: applications relevant the mission http://www.ninds.nih.gov/about_ninds/mission.htm) the National Institute Neurological Disorders Stroke NINDS): NINDS not accept applications under announcement include clinical trials https://grants.nih.gov/grants/guide/notice-files/NOT-OD-15-015.html). clinical trial a prospective biomedical behavioral research study human subjects designed answer specific questions safety, tolerability, efficacy and/or effectiveness pharmacologic, behavioral, biologic, surgical, device invasive non-invasive) interventions. human subjects research be submitted NINDS decline funding any application includes human subjects programmatic administrative reasons. Applicants considering projects involving human subjects research strongly encouraged contact Scientific/Research staff. Modified read: Components Participating Organizations National Cancer Institute NCI) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Drug Abuse NIDA) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) Catalog Federal Domestic Assistance CFDA) Number(s) 93.865; 93.399; 93.396; 93.395; 93.394; 93.393; 93.279; 93.846 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Nick Langhals, Ph.D. National Institute Neurological Disorders Stroke Telephone: 301-496-1447 Email: nick.langhals@nih.gov

Notice NINDS Policy Submission Applications Participation PA-18-345 NIH Research Project Grant Parent R01) - Clinical Trial Required". NINDS Only accepts Clinical Trial Applications Proposing Mechanistic Studies Clinical Trial Parent R01 Notice Number: NOT-NS-18-011 Key Dates Release Date: December 18, 2017 Related Announcements PA-18-345 NOT-NS-18-054 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to announce NINDSs participation the NIH Research Project Grant Parent R01 Clinical Trial Required) Funding Opportunity Announcement FOA) subsequent reissuances these FOAs. applications submitted or after January 25, 2018, NINDS only accept applications this FOA propose human mechanistic trials/studies meet NIH's definition a clinical trial that fall within NINDS research priorities. NIH defines clinical trial A research study which or human subjects prospectively assigned one more interventions may include placebo other control) evaluate effects those interventions health-related biomedical behavioral outcomes. NOT-OD-15-015) NIH defines mechanistic clinical trial follows: mechanistic study designed understand biological behavioral process, pathophysiology a disease, the mechanism action an intervention. NINDS supports hypothesis-driven mechanistic clinical trial studies basic and/or translational discovery research healthy human subjects in pathobiology, pathophysiology, neuropathology neurological disorders. goal to address basic questions to interrogate concepts biology, behavior, pathophysiology will provide insight understanding neurological disorders. Such studies seek understand biological behavioral process, the mechanism action an intervention. NINDS supports biomarker studies may provide information physiological function, target engagement novel therapeutics, and/or mechanisms therapeutic responses. submitted studies defined clinical trials noted above) do seek answer specific questions safety, tolerability, clinical efficacy, effectiveness, clinical management, and/or implementation pharmacologic, behavioral, biologic, surgical, device invasive non-invasive) interventions. preventive, therapeutic, services interventions. Such designs should submitted an NINDS clinical trial-specific funding announcement listed the NINDS website https://www.ninds.nih.gov/Current-Research/Research-Funded-NINDS/Clinic…). Applicants strongly advised consult NINDS program staff prior submitting application human subjects determine appropriate funding opportunity. Examples types applications intended be supported NINDS under NIH Parent Clinical Trial R01 FOA include, are limited to: Studies which manipulation physiological behavioral) used answer basic science questions normal brain function. Studies develop, validate, and/or apply novel measures brain signaling circuits healthy humans including, example, PET, SPECT, other neuroimaging approaches, well biomarkers physiological processes. Studies use experimental manipulation e.g., CNS active drugs, direct neurostimulation cognitive task activating specific neural circuit) order understand normal functioning the pathophysiology a neurological disorder, do aim demonstrate clinical improvement. Studies involve prospective of efficacious interventions e.g., biomedical, behavioral, cognitive, therapeutic approaches), where intent to obtain biospecimens e.g., blood, patient-derived induced pluripotent stem cells) identify genetic risk associations, novel biomarkers, examine disease process, characterize mechanisms therapeutic response. Studies which intervention demonstrated efficacy that population being studied understand mechanisms response, non-response, risk adverse effects the efficacious intervention. following types clinical trials not intended be supported NINDS under NIH Parent Clinical Trials R01 FOA: Studies do meet NIH definition clinical trial. Early-stage trials novel treatment approaches humans are prerequisite clinical efficacy trials pharmacological, device, behavioral intervention development. Studies develop conduct tests the clinical efficacy/effectiveness treatments. Studies have safety, clinical efficacy, clinical management, and/or implementation its principal aim. Resource Does human subjects research study meet definition a clinical trial? Part 1. Overview Information Components Participating Organizations National Center Complementary Integrative Health NCCIH) National Heart, Lung, Blood Institute NHLBI) National Human Genome Research Institute NHGRI) National Institute Drug Abuse NIDA) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Allergy Infectious Diseases NIAID) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) National Institute Environmental Health Sciences NIEHS) National Institute General Medical Sciences NIGMS) National Institute Minority Health Health Disparities NIMHD) National Institute Nursing Research NINR) National Institute Neurological Disorders Stroke NINDS) Catalog Federal Domestic Assistance CFDA) Number(s) 93.853 Inquiries Please direct inquiries to: Claudia Moy, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9135 Email: moyc@ninds.nih.gov

Notice Clarification NINDS Statement interest PAR-18-208 Bioengineering Research Partnerships BRP) U01 Clinical Trial Optional)" Notice Number: NOT-NS-18-029 Key Dates Release Date:   December 18, 2017 Related Announcements PAR-18-208 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to revise NINDS interest statement PAR-18-208. current language reads: Part 2. Full Text Announcement Section I. Funding Opportunity Description Institute statements interest:   applications relevant the mission http://www.ninds.nih.gov/about_ninds/mission.htm) the National Institute Neurological Disorders Stroke NINDS) under FOA: Applications should milestone-driven, translational engineering development regulatory approval targeted, diagnostic devices excluding neuro-imaging). nbsp;Specific go/no-go milestones be negotiated NINDS Program staff the time award inclusion the notice award.  Applications proposing translational studies designed pre-clinical pilot clinical studies therapeutic devices, specifically, should submitted one the following NINDS CREATE Devices FOAs http://www.ninds.nih.gov/funding/areas/translational_research/CREATE-De…).  Applications NINDS proposing pre-translational, pre-clinical, investigative research projects deliberative optimization development devices impacts neurology neuroscience should apply through Bioengineering Research Grants R01) Exploratory Bioengineering Research Grants R21) refer 2018 FOAs].  NINDS not accept applications under announcement include clinical trials https://grants.nih.gov/grants/guide/notice-files/NOT-OD-15-015.html). clinical trial a prospective biomedical behavioral research study human subjects designed answer specific questions safety, tolerability, efficacy and/or effectiveness pharmacologic, behavioral, biologic, surgical, device invasive non-invasive) interventions. human subjects research be submitted NINDS decline funding any application includes human subjects programmatic administrative reasons. Applicants considering projects involving human subjects research strongly encouraged contact Scientific/Research staff.  Applications NINDS proposing clinical trial must submitted one the following NINDS FOAs specifically designed clinical trials http://www.ninds.nih.gov/research/clinical_research/index.htm#tab3-panel) language been modified now reads: Part 2. Full Text Announcement Section I. Funding Opportunity Description Institute statements interest: NINDS: Within goals this FOA, NINDS particularly interested bioengineering research advances technologies the potential decrease burden neurological disorders stroke. Examples areas interest include development validation invasive non-invasive devices, diagnostic/monitoring tools, advanced imaging techniques, computational models, tissue engineering, other innovative methods. Applicants strongly encouraged contact NINDS Scientific Program staff prior submission. Applicants interested translational activities clinical studies therapeutic diagnostic devices disorders affect nervous neuromuscular systems be appropriate other NINDS bioengineering opportunities https://www.ninds.nih.gov/Current-Research/Focus-Research/Focus-Bioengi…). Inquiries Please direct inquiries to: Nick Langhals, Ph.D. National Institute Neurological Disorders Stroke Telephone: 301-496-1447 Email: nick.langhals@nih.gov

Notice NINDS' Participation PA-18-403 Ruth L. Kirschstein National Research Service Award NRSA) Institutional Research Training Grant Parent T32)" Notice Number: NOT-NS-18-022 Key Dates Release Date:   December 14, 2017 Related Announcements PA-18-403 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to inform potential applicants the National Institute Neurological Disorders Stroke NINDS) participate, effective immediately, PA-18-403 quot;Ruth L. Kirschstein National Research Service Award NRSA) Institutional Research Training Grant Parent T32)" following italicized changes made indicate participation NINDS this FOA.  Part 1. Overview Information Components Participating Organizations National Cancer Institute NCI) National Eye Institute NEI) National Human Genome Research Institute NHGRI) National Institute Aging NIA) National Institute Allergy Infectious Diseases NIAID) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Diabetes Digestive Kidney Diseases NIDDK) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute General Medical Sciences NIGMS) National Institute Mental Health NIMH) National Institute Nursing Research NINR) National Center Complementary Integrative Health NCCIH) Division Program Coordination, Planning Strategic Initiatives, Office Research Infrastructure Programs ORIP) National Institute Neurological Disorders Stroke NINDS) Catalog Federal Domestic Assistance CFDA) Number(s) 93.242; 93.351; 93.846; 93.113; 93.847; 93.866; 93.173; 93.279; 93.361; 93.865; ; 93.855; 93.398; 93.859; 93.867; 93.213; 93.286; 93.853 nbsp;   other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Stephen Korn, Ph.D. National Institute Neurological Disorders Stroke Telephone: 301-496-188 Email: korns@mail.nih.gov

Notice Clarification NINDS Statement interest Bioengineering Research Grants BRG) R01 Clinical Trial Optional)" Notice Number: NOT-NS-18-028 Key Dates Release Date:   December 14, 2017 Related Announcements PAR-18-206 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to revise NINDS interest statement PAR-18-206. current language reads: Part 2. Full Text Announcement Section I. Funding Opportunity Description IC-Specific Interests   NINDS: NINDS not accept applications under announcement include clinical trials https://grants.nih.gov/grants/guide/notice-files/NOT-OD-15-015.html). clinical trial a prospective biomedical behavioral research study human subjects designed answer specific questions safety, tolerability, efficacy and/or effectiveness pharmacologic, behavioral, biologic, surgical, device invasive non-invasive) interventions. human subjects research be submitted NINDS decline funding any application includes human subjects programmatic administrative reasons. Applicants considering projects involving human subjects research strongly encouraged contact Scientific/Research staff. Applications proposing non-clinical studies concluding a clinical trial should submitted one the following NINDS CREATE Devices FOAs specifically designed pre-clinical pilot clinical studies therapeutic devices http://www.ninds.nih.gov/funding/areas/translational_research/CREATE-De…). Applications proposing clinical trial must submitted one the following NINDS FOAs specifically designed clinical trials http://www.ninds.nih.gov/research/clinical_research/index.htm#tab3-panel) language been modified now reads: Part 2. Full Text Announcement Section I. Funding Opportunity Description IC-Specific Interests NINDS: Within goals this FOA, NINDS particularly interested bioengineering research advances technologies the potential decrease burden neurological disorders stroke. Examples areas interest include development validation invasive non-invasive devices, diagnostic/monitoring tools, advanced imaging techniques, computational models, tissue engineering, other innovative methods. Applicants strongly encouraged contact NINDS Scientific Program staff prior submission. Applicants interested translational activities clinical studies therapeutic diagnostic devices disorders affect nervous neuromuscular systems be appropriate other NINDS bioengineering opportunities https://www.ninds.nih.gov/Current-Research/Focus-Research/Focus-Bioengi…). other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Nick Langhals, Ph.D. National Institute Neurological Disorders Stroke Telephone: 301-496-1447 Email: nick.langhals@nih.gov

Notice National Institute Neurological Disorders Stroke NINDS) National Institute Drug Abuse NIDA) Interest Blueprint Neurotherapeutic Network Applications Directed Small Molecule Non-Addictive Pain Therapies Notice Number: NOT-NS-18-027 Key Dates Release Date: December 13, 2017 Related Announcements PAR-17-201 PAR-17-205   Issued National Institute Neurological Disorders Stroke NINDS) National Institute Drug Abuse NIDA) Purpose purpose this Notice to inform potential applicants concerned the NIH Blueprint Neurotherapeutics Network BPN) Funding Opportunity Announcements the areas special interest. National Institute Neurological Disorders Stroke NINDS) interested receiving applications directed identifying developing new small molecule pain therapies. National Institute Drug Abuse NIDA) specifically interested receiving highly innovative applications, entering BPN the discovery phase only, directed identifying new small molecules devoid addictive properties the treatment pain. Additionally, BPN hold informational webinar the program potential applicants. webinar recommended investigators have small molecule validated hit compounds the disease biology assays drive lead optimization are interested learning the BPN it virtual pharma model brings NIH investigators together NIH expertise, seasoned industry consultants BPN's contract resources. webinar optional not required submission applications. WEBINAR INFORMATION Informational Webinar the Blueprint Neurotherapeutic Network January 3, 2018 3:30 p.m.- 4:30 Eastern Time Please visit following link register the webinar: Link webinar registration button available the bottom the page. Inquiries Please direct inquiries to: Charles L. Cywin, Ph.D. Program Director, Blueprint Neurotherapeutics Network National Institute Neurological Disorders Stroke Telephone: 301-496-1779 Email: charles.cywin@nih.gov Stephanie Fertig National Institute Neurological Disorders Stroke NINDS) Telephone:301-496-1779 Email: fertigs@ninds.nih.gov Elena Koustova, PhD, MBA National Institute Drug Abuse NIDA) Telephone: 301-496-8768 Email: koustovae@mail.nih.gov Michael Oshinsky, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9964 Email: michael.oshinsky@nih.gov Tanya Tatiana) Ramey, MD PhD National Institute Drug Abuse NIDA) Telephone: 301-827 5944 Email: tanya.ramey@nih.gov nbsp;

Collaborative Research Computational Neuroscience CRCNS) NSFInnovative Approaches Science Engineering Research Brain Function Notice Number: NOT-MH-18-012 Key Dates Release Date: December 11, 2017 Related Announcements NOT-MH-18-003 Issued National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Institute Drug Abuse NIDA) National Institute Deafness Other Communication Disorders NIDCD) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) National Center Complementary Integrative Health NCCIH) Purpose Notice announces reissue a joint initiative, Collaborative Research Computational Neuroscience CRCNS), among six National Science Foundation NSF) Directorates Offices DOs), nine participating National Institutes Health NIH) Institutes Centers ICs).  Notice supplements NOT-MH-18-003 reiterates involvement all ICs listed above. CRCNS announcement released under NSF 18-501 https://www.nsf.gov/publications/pub_summ.jsp?ods_key=nsf18501). announcement supersedes NSF 16-607: Collaborative Research Computational Neuroscience CRCNS) – Innovative Approaches Science Engineering Research Brain Function. German Federal Ministry Education Research Bundesministerium für Bildung und Forschung, BMBF http://www.bmbf.de/), French National Research Agency Agence Nationale de la Recherche, ANR http://www.agence-nationale-recherche.fr), U.S.-Israel Binational Science Foundation BSF http://www.bsf.org.il) and National Institute Information Communications Technology NICT, https://www.nict.go.jp/en/) now formal partners this program, along NSF the NIH. NIH, CRCNS now affiliated the NIH Blueprint Neuroscience Research http://neuroscienceblueprint.nih.gov). Computational neuroscience provides theoretical foundation a rich set technical approaches understanding complex neurobiological systems, building the theory, methods, findings computer science, neuroscience, numerous disciplines. Through CRCNS program, NSF, NIH, BMBF, ANR, BSF, NICT support collaborative activities will advance understanding nervous system structure function, mechanisms underlying nervous system disorders, computational strategies used the nervous system. classes proposals be considered response this solicitation: Research Proposals describing collaborative research projects; Data Sharing Proposals to enable sharing data other resources. Domestic international projects be considered. detailed the solicitation, international components collaborative projects be funded parallel the participating agencies. Specific CRCNS opportunities parallel funding available bilateral US-German Research Proposals, US-German Data Sharing Proposals, US-French Research Proposals, US-French Data Sharing Proposals, US-Israeli Research Proposals, US-Israeli Data Sharing Proposals, US-Japanese Research Proposals, US-Japanese Data Sharing Proposals, multilateral proposals involving United States 2 more partnering countries Germany, France, Israel, and/or Japan; please Section VIII the solicitation country-specific instructions limitations). Appropriate scientific areas investigations be related the interests any the participating funding organizations. Questions concerning particular project’s focus, direction relevance a participating funding agency should addressed the appropriate person the list agency contacts the NSF Program Solicitation NSF 18-501, https://www.nsf.gov/publications/pub_summ.jsp?ods_key=nsf18501). computational research supported under program must impact on, relate biological processes, optimally generate hypotheses are testable biological studies. is expected that: 1) applications include collaborations among computational and/or modeling experts, theorists, experimental neuroscientists; 2) collaborations involve dynamic and, possibly, protracted period model theory development refinement, intense interaction among scientists engineers different disciplines; 3) development testing new models theories provide framework the design experiments the generation new hypotheses can help reveal mechanisms underlying normal disease states the nervous system, 4) development distribution professional quality software tools e.g., modeling algorithms analytic tools). NSF coordinate manage review proposals jointly participating domestic foreign funding organizations, through joint panel review process used all participating funders. Additional information available the NSF Program Solicitation NSF 18-501, https://www.nsf.gov/publications/pub_summ.jsp?ods_key=nsf18501). Applications submitted response this solicitation not duplicate be substantially similar other applications concurrently under consideration other programs study sections across agencies, including NIH investigator-initiated parent’ FOAs NIH BRAIN Initiative FOAs. Duplicate substantially similar applications be returned without review.  Award Information Award sizes research projects expected range approximately 100,000 250,000 per year direct costs, durations three five years. Many awards be the smaller end this range; award exceed 250,000 per year direct costs. Applicants strongly discouraged requesting greater budgets are necessary the activities being proposed. is estimated data sharing projects range approximately 25,000 100,000 cumulative award size a one- three-year project. Estimated program budget, number awards average award size duration subject the availability funds. Upon conclusion the review process, meritorious applications be recommended funding either participating NSF DOs NIH ICs, the option the agencies, the applicant. Subsequent grant administration procedures be accordance the individual policies the awarding agency. Eligibility Information Limit Number Proposals per PI Collaborator: 2 response this solicitation, investigator participate PI Collaborator no than proposals per review cycle. the event a PI Collaborator does appear either these roles more two proposals, proposals include person a PI Collaborator be returned without review. This limit applies all PIs Collaborators, based inside outside the United States. Proposal Preparation Submission Instructions Applications submitted response this announcement should prepared submitted accordance the general guidelines contained the NSF Proposal & Award Policies & Procedures Guide PAPPG). Applications must submitted the NSF, to NIH. complete text the PAPPG available electronically the NSF Web Site at: http://www.nsf.gov/publications/pub_summ.jsp?ods_key=pappg. Applicants reminded identify announcement number NSF 18-501) the program announcement block the NSF Cover Sheet Proposal the National Science Foundation. Compliance this announcement critical determining relevant proposal processing guidelines. Failure submit information delay processing. Budgetary Information Inclusion voluntary committed cost sharing prohibited proposals submitted NSF under solicitation. Budgets should include travel funds the PI team members attend annual CRCNS Principal Investigators' meeting. NIH Process those proposals are selected potential funding participating NIH ICs, PI be required resubmit proposal an NIH-approved format directly the Center Scientific Review http://www.csr.nih.gov/) the NIH. PIs invited resubmit NIH receive further information resubmission procedures the NIH. applicant not allowed increase proposed budget change scientific content the application the resubmission the NIH.  applicants be expected utilize Multiple Program Director/Principal Investigator option the NIH http://grants.nih.gov/grants/multi_PI/) appropriate. These NIH applications be entered the NIH IMPAC II system. The results the review be presented the involved IC's National Advisory Councils the second level review. Subsequent the Council reviews, NIH ICs make funding determinations selected awards be made. Subsequent grant administration procedures NIH awardees, including those related New Early Stage Investigators http://grants.nih.gov/grants/new_investigators/) be accordance the policies NIH. Applications selected NIH funding use NIH R01 funding mechanism. Inquiries Written telephone inquiries encouraged.  Please the NSF program announcement names contact information each the participating NSF DOs and/or NIH ICs at https://www.nsf.gov/publications/pub_summ.jsp?ods_key=nsf18501