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Extended Deadline Request Information RFI): Priorities Outsourcing Laboratory Procedures Notice Number: NOT-GM-12-110 Key Dates Release Date: 9, 2012 New Deadline Date:  COB 15, 2012 Related Notices NOT-GM-12-108 Issued National Institute General Medical Sciences NIGMS) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) National Institute Environmental Health Sciences NIEHS) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Alternative Medicine NCCAM) Purpose purpose this Notice to announce extension the deadline the Request Input RFI) researchers regarding current research laboratory procedures could developed outsourced services initially released NOT-GM-12-108.  convenience, relevant text the RFI appended below. development research laboratory procedures could developed outsourced services potentially facilitate broad access state-of-the-art technologies methodologies research areas high significance the mission the NIH, particularly the participating Institutes NIGMS, NINDS, NCCAM, NIEHS, NIAMS) not limited them. Clinical services expressly excluded. information be used develop funding initiatives through Small Business Innovation Research SBIR/STTR) Program. RFI for planning purposes only should be construed a funding opportunity grant program. Background Recent technological advances opened new doors solving biomedical problems.  However, access the newest technologies procedures present major expense, especially institutions lacking extensive core facilities.  possibility make such technologies procedures accessible a much wider range investigators to promote outsourcing supporting research development commercially viable pipelines such procedures.   efforts result multiple advantages the biomedical enterprise companies provide appropriate assays, measurements, data, bioinformatics other types research services.  advantages include reduced overall costs research grants, enhanced quality control, timely access.  general concept not novel e.g., oligonucleotide synthesis, expression array services, knockout mice generation) there be unexplored opportunities further outsourcing. Benefits increased outsourcing research services have recognized include enhancing access the acceleration progress Science 334, 1154-1156, Nov 2011), well for establishment broad method data validation standards Science 334, 1230-32; Dec 2011). Therefore, stimulating establishment expansion small business outsourcing services further both mission the NIH general, those the SBIR program particular i.e., stimulation technological innovation, support federal R&D goals). untested proposition that market exists services would justify investment small businesses research development costs.  assumption rests the hypothesis there lab-based, non-clinical technologies procedures are amenable scale-up, not already being provided, which be attractive investigators hitherto not used such services could convinced otherwise their quality lower costs.  purpose this RFI to obtain data evaluate proposition. Information Requested request include is limited concerns such as: 1. Research services which see unmet demand outsourcing the perspective your own research the broader scientific area. 2. likely market such services, including research areas be affected beyond own interests. 3. Special obstacles technological, logistical, costs) currently impede development the services identify. 4. Services sense particularly sensitive obsolescence, any. 5. Services may already on market where access quality limited unsatisfactory. 6. comments, suggestions, considerations relevance this RFI. Indicate primary affiliation optional). to Submit Response Response this RFI voluntary.  Extramural investigators other interested parties invited respond. Responders free address any all the above items. comments must submitted electronically to: http://public.nigms.nih.gov/sbir/. Please respond COB 15, 2012. Any personal identifiers be removed responses compiled. Proprietary, classified, confidential, sensitive information should be included your response. information provided be analyzed may appear various reports. Request Information RFI) for planning purposes only is a solicitation application an obligation the part the United States U.S.) Government provide support any ideas identified response it. Please note the U.S. Government not pay the preparation any comment submitted for use that comment. Inquiries Please direct inquiries to: James J. Anderson, Ph.D. Program Director, Division Genetics Developmental Biology Center Bioinformatics Computational Biology National Institute General Medical Sciences NIGMS) Tel: 301-594-0943 E-mail: andersj@mail.nih.gov Stefan Maas, Ph.D. Program Director, Division Genetics Developmental Biology National Institute General Medical Sciences NIGMS) Tel: 301-594-0943 E-mail: stefan.maas@nih.gov Xibin Wang, Ph.D. Research Program Analyst Division Musculoskeletal Diseases National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) Tel: 301-451-3884 Email: wangx1@mail.nih.gov Daniel Shaughnessy, PhD National Institute Environmental Health Sciences NIEHS) Tel: 919-541-2506 Email: shaughn1@niehs.nih.gov Stephanie Fertig, MBA Small Business Program National Institute of Neurological Disorders Stroke NINDS) Tel: 301- 496-1779 E-mail: fertigs@ninds.nih.gov D. Craig Hopp, Ph.D. Program Officer National Center Complementary Alternative Medicine National Institutes Health NCCAM) Tel: 301-496-5825 E-mail: hoppdc@mail.nih.gov

Notice Change Participation NIH Institutes Centers PAS-12-169 Limited Competition: Revision Applications Advance Evidence-Based Research Related Protections Human Subjects U54) Notice Number: NOT-OD-12-105 Key Dates Release Date: April 30, 2012 Issued National Institutes Health NIH) Purpose purpose this Notice to inform potential applicants the addition the National Institute Biomedical Imaging Bioengineering NIBIB) the NIH Institutes participating PAS-12-169 ldquo;Limited Competition: Revision Applications Advance Evidence-Based Research Related Protections Human Subjects U54)” Components Participating Organizations: National Cancer Institute NCI) National Heart, Lung, Blood Institute NHLBI) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Dental Craniofacial Research NIDCR) National Institute Diabetes Digestive Kidney Diseases NIDDK) National Institute Neurological Disorders Stroke NINDS) National Library Medicine NLM) Catalog Federal Domestic Assistance CFDA) Number: NIBIB CFDA number been added. nbsp;93.286 Agency Contacts: following agency contact NIBIB been added. nbsp;  Financial/Grants Management Contact(s) Nancy Curling National Institute Biomedical Imaging Bioengineering Democracy II, Suite 900 Bethesda, MD 20892-5469 Telephone: 496-9315 Email:  nc23a@nih.gov other aspects this FOA remain unchanged. Inquiries Please direct inquiries the Scientific/Research Contact listed the FOA.

Change Receipt Date RFA-NS-13-003, quot;NIH Blueprint Neuroscience Research Grand Challenge: Discovering Novel Drugs Disorders the Nervous System U01)" Notice Number: NOT-NS-12-014 Key Dates Release Date:   April 19, 2012 Issued NIH Blueprint Neuroscience Research National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Dental Craniofacial Research NIDCR) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute General Medical Sciences NIGMS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) National Center Complementary Alternative Medicine NCCAM) Office Behavioral Social Sciences Research OBSSR) Purpose National Institutes Health NIH) Blueprint Neuroscience Research wishes give notice a change receipt date applications submitted response RFA-NS-13-003, NIH Blueprint Neuroscience Research Grand Challenge: Discovering Novel Drugs Disorders the Nervous System U01).” Request Applications RFA) published the NIH Guide Grants Contracts February 21, 2012. previous receipt date June 8, 2012 been changed October 8, 2012. Key Dates section RFA-NS-13-003 been revised follows reflect change described above: Key Dates Old Key Dates Posted Date February 21, 2012 Open Date Earliest Submission Date) 8, 2012 nbsp; Letter Intent Due Date 8, 2012 nbsp; Application Due Date(s) June 8, 2012, 5:00 PM local time applicant organization. AIDS Application Due Date(s) Applicable nbsp; Scientific Merit Review September 2012 Advisory Council Review January 2013 Earliest Start Date(s) April 1, 2013 Expiration Date June 9, 2012 Due Dates E.O. 12372 Applicable New Key Dates Posted Date February 21, 2012 Open Date Earliest Submission Date) September 8, 2012 nbsp; Letter Intent Due Date September 8, 2012 Application Due Date(s) October 8, 2012, 5:00 PM local time applicant organization. AIDS Application Due Date(s) Applicable nbsp; Scientific Merit Review December 2012 nbsp; Advisory Council Review January 2013 nbsp; Earliest Start Date(s) April 1, 2013 Expiration Date October 9, 2012 nbsp; Due Dates E.O. 12372 Applicable other aspects this FOA remain unchanged.  Inquiries Please direct inquiries to: Rebecca Farkas, PhD Office Translational Research National Institute Neurological Disorders Stroke 6001 Executive Boulevard Neuroscience Center/Room 2109 Bethesda, MD 20892 Telephone: 301) 496-1779 FAX: 301-402-1501 Email: farkasr@ninds.nih.gov

Frequently Asked Questions FAQs) RFA-NS-12-010 - Exploratory Laboratory Analysis Projects Parkinson’s Disease Biomarkers U18) RFA-NS-12-011 - Studies Parkinson's Disease Biomarkers Discovery U01) Notice Number: NOT-NS-12-015 Key Dates Release Date: April 19, 2012   Issued National Institute Neurological Disorders Stroke NINDS)   Purpose March 16th, 2012, NINDS issued Funding Opportunity Announcements FOAs): RFA-NS-12-010 - Exploratory Laboratory Analysis Projects Parkinson's Disease Biomarkers U18) RFA-NS-12-011 - Studies Parkinson's Disease Biomarkers Discovery U01). goal RFA-NS-12-010 to stimulate innovation development technologies reagents will accelerate discovery biological biomarkers Parkinson’s disease PD).  goal RFA-NS-12-011 to support hypothesis driven clinical research discover biomarkers will improve efficiency outcome Phase II clinical trials Parkinson’s Disease PD) to support collection clinical data new biological specimens will used biomarker exploratory efforts under NINDS Parkinson’s Disease Biomarkers Program PDBP). date, several questions these FOAs been submitted various investigators. purpose this Notice to inform potential applicants a list Frequently Asked Questions FAQs) answers available http://www.ninds.nih.gov/pdbp/). FAQs be updated periodically without additional notice.  Inquiries questions further information, contact: Katrina Gwinn MD National Institute Neurological Disorders Stroke 6001 Executive Blvd Room 2143 Bethesda MD 20892 Telephone: 301-496-5745 Fax: 301-502-1501 Email: gwinnk@ninds.nih.gov

Extension Expiration Date PAR-11-293, NINDS Exploratory/Developmental Projects Translational Research R21) Notice Number: NOT-NS-12-010 Key Dates Release Date: April 9, 2012 Related Notices NOT-NS-12-011 NOT-NS-12-012 NOT-NS-12-013 Issued National Institute Neurological Disorders Stroke NINDS) Purpose Notice extends expiration date Funding Opportunity Announcement FOA) PAR-11-293,   NINDS Exploratory/Developmental Projects Translational Research R21). new expiration date PAR-11-293 January 8, 2013. other aspects the FOA remain unchanged. Inquiries Please direct inquiries to: Christina Vert, M.S. Office Translational Research National Institute Neurological Disorders Stroke NINDS) 6001 Executive Blvd., Room 2117 Bethesda, MD 20892 Telephone: 301) 496-1779 Email: vertc@ninds.nih.gov

Extension Expiration Date PAR-11-294, NINDS Cooperative Program Translational Research Single-Component Research Projects U01) Notice Number:  NOT-NS-12-011 Key Dates Release Date: April 10, 2012 Related Notices NS-12-010 NS-12-012 NOT-NS-12-013 Issued National Institute Neurological Disorders Stroke NINDS) Purpose Notice extends expiration date Funding Opportunity Announcement FOA) PAR-11-294, NINDS Cooperative Program Translational Research Single-Component Research Projects U01). new expiration date PAR-11-294 January 8, 2013. other aspects the FOA remain unchanged. Inquiries Please direct inquiries to: Linda McGavern, Ph.D. Office Translational Research National Institute Neurological Disorders Stroke NINDS) 6001 Executive Blvd., Room 2227 Bethesda, MD 20892 Telephone: 301) 496-1779 Email: mcgavernlm@ninds.nih.gov

Extension Expiration Date PAR-11-295, NINDS Cooperative Program Translational Research Multi-Component Research Projects U54) Notice Number: NOT-NS-12-012 Key Dates Release Date: April 10, 2012 Related Notices NOT-NS-12-010 NOT-NS-12-011 NOT-NS-12-013 Issued National Institute Neurological Disorders Stroke NINDS) Purpose Notice extends expiration date Funding Opportunity Announcement FOA) PAR-11-295, NINDS Cooperative Program Translational Research Multi-Component Research Projects U54). new expiration date PAR-11-295 January 8, 2013. other aspects the FOA remain unchanged. Inquiries Please direct inquiries to: Linda McGavern, Ph.D. Office Translational Research National Institute Neurological Disorders Stroke NINDS) 6001 Executive Blvd., Room 2227 Bethesda, MD 20892 Telephone: 301) 496-1779 Email: mcgavernlm@ninds.nih.gov

Extension Expiration Date PAR-11-296, NINDS Cooperative Program Translational Research Small Business Awards U44) Notice Number: NOT-NS-12-013 Key Dates Release Date: April 10, 2012   Related Notices NOT-NS-12-010 NOT-NS-12-011 NOT-NS-12-012   Issued National Institute Neurological Disorders Stroke NINDS) Purpose Notice extends expiration date Funding Opportunity Announcement FOA) PAR-11-296, NINDS Cooperative Program Translational Research Small Business Awards U44). new expiration date PAR-11-296 January 8, 2013. other aspects the FOA remain unchanged. Inquiries Please direct inquiries to: Linda McGavern, Ph.D. Office Translational Research National Institute Neurological Disorders Stroke NINDS) 6001 Executive Blvd., Room 2227 Bethesda, MD 20892 Telephone: 301) 496-1779 Email: mcgavernlm@ninds.nih.gov

Request Information RFI): Priorities Outsourcing Laboratory Procedures Notice Number: NOT-GM-12-108 Update: following update relating this announcement been issued: 9, 2012 - Notice NOT-GM-12-110. purpose this Notice to announce extension the deadline the Request Input RFI). Key Dates Release Date: March 30, 2012 Response Date COB:  Extended COB 15, 2012 per NOT-GM-12-110), Original Date 1, 2012 Issued National Institute General Medical Sciences NIGMS) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) National Institute Environmental Health Sciences NIEHS) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Alternative Medicine NCCAM) Purpose purpose this Request Information RFI) to seek input researchers regarding current research laboratory procedures could developed outsourced services.  development such services potentially facilitate broad access state-of-the-art technologies methodologies research areas high significance the mission the NIH, particularly the participating Institutes NIGMS, NINDS, NCCAM, NIEHS, NIAMS) not limited them. Clinical services expressly excluded. information be used develop funding initiatives through Small Business Innovation Research SBIR/STTR) Program. RFI for planning purposes only should be construed a funding opportunity grant program. Background Recent technological advances opened new doors solving biomedical problems.  However, access the newest technologies procedures present major expense, especially institutions lacking extensive core facilities.  possibility make such technologies procedures accessible a much wider range investigators to promote outsourcing supporting research development commercially viable pipelines such procedures.   efforts result multiple advantages the biomedical enterprise companies provide appropriate assays, measurements, data, bioinformatics other types research services.  advantages include reduced overall costs research grants, enhanced quality control, timely access.  general concept not novel e.g., oligonucleotide synthesis, expression array services, knockout mice generation) there be unexplored opportunities further outsourcing. Benefits increased outsourcing research services have recognized include enhancing access the acceleration progress Science 334, 1154-1156, Nov 2011), well for establishment broad method data validation standards Science 334, 1230-32; Dec 2011). Therefore, stimulating establishment expansion small business outsourcing services further both mission the NIH general, those the SBIR program particular i.e., stimulation technological innovation, support federal R&D goals). untested proposition that market exists services would justify investment small businesses research development costs.  assumption rests the hypothesis there lab-based, non-clinical technologies procedures are amenable scale-up, not already being provided, which be attractive investigators hitherto not used such services could convinced otherwise their quality lower costs.  purpose this RFI to obtain data evaluate proposition. Information Requested request include is limited concerns such as: 1. Research services which see unmet demand outsourcing the perspective your own research the broader scientific area. 2. likely market such services, including research areas be affected beyond own interests. 3. Special obstacles technological, logistical, costs) currently impede development the services identify. 4. Services sense particularly sensitive obsolescence, any. 5. Services may already on market where access quality limited unsatisfactory. 6. comments, suggestions, considerations relevance this RFI. Indicate primary affiliation optional). to Submit Response Response this RFI voluntary.  Extramural investigators other interested parties invited respond. Responders free address any all the above items. comments must submitted electronically to: http://public.nigms.nih.gov/sbir/.  Please respond COB 1, 2012. Any personal identifiers be removed responses compiled. Proprietary, classified, confidential, sensitive information should be included your response. information provided be analyzed may appear various reports. Request Information RFI) for planning purposes only is a solicitation application an obligation the part the United States U.S.) Government provide support any ideas identified response it. Please note the U.S. Government not pay the preparation any comment submitted for use that comment. Inquiries Please direct inquiries to: James J. Anderson, Ph.D. Program Director, Division Genetics Developmental Biology Center Bioinformatics Computational Biology National Institute General Medical Sciences NIGMS) Tel: 301-594-0943 E-mail: andersj@mail.nih.gov Stefan Maas, Ph.D. Program Director, Division Genetics Developmental Biology National Institute General Medical Sciences NIGMS) Tel: 301-594-0943 E-mail: stefan.maas@nih.gov Xibin Wang, Ph.D. Research Program Analyst Division Musculoskeletal Diseases National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) Tel: 301-451-3884 Email: wangx1@mail.nih.gov Daniel Shaughnessy, PhD National Institute Environmental Health Sciences NIEHS) Tel: 919-541-2506 Email: shaughn1@niehs.nih.gov Stephanie Fertig, MBA Small Business Program National Institute of Neurological Disorders Stroke NINDS) Tel: 301- 496-1779 E-mail: fertigs@ninds.nih.gov D. Craig Hopp, Ph.D. Program Officer National Center Complementary Alternative Medicine National Institutes Health NCCAM) Tel: 301-496-5825 E-mail: hoppdc@mail.nih.gov

NSF-NIH Interagency Initiative: Core Techniques Technologies Advancing Big Data Science Engineering BIGDATA) Notice Number: NOT-GM-12-109 Key Dates Release Date:  March 29, 2012          Issued National Institute General Medical Sciences NIGMS), http://www.nigms.nih.gov/) National Cancer Institute NCI), http://www.nci.nih.gov/) National Human Genome Research Institute, http://www.nhgri.nih.gov) National Institute Biomedical Imaging Bioengineering NIBIB), http://www.nibib.nih.gov/) National Institute Drug Abuse NIDA), http://www.nida.nih.gov/) National Institute Neurological Disorders Stroke NINDS), http://www.ninds.nih.gov/) National Library Medicine NLM), http://www.nlm.nih.gov/) Purpose Institutes Centers the National Institutes Health NIH) the National Science Foundation NSF) identified Big Data a program focus.  particular, present initiative covers needs core techniques technologies advancing big data science engineering. Full details the programmatic goals application process described the NSF Program Solicitation NSF-12-499). Description:  BIGDATA seeks applications develop evaluate core technologies tools take advantage available collections large data sets accelerate progress science, biomedical research, engineering. addition, applications must also include description how project build capacity.  Also, project choose focus science engineering big data project an area national priority, this optional. small project receive NIH support to 150,000 direct funds to 3 years, while mid-scale projects receive NIH support ranging 150,000 650,000 direct funds to 5 years.  all, participating NIH Institutes committed to 2.75M FY 2012 and/or 2013.   It anticipated NIH pay 4 6 small projects 1 2 mid-scale projects through program fiscal years 2012 and/or 2013, subject availability funds.  Application submission through National Science Foundation. Following jointly conducted initial peer review these applications, likely NIH awardees be asked reformat application resubmit application NIH processing. Detailed information this program be obtained the Internet www.nsf.gov/funding/pgm_summ.jsp?pims_id=504767 Inquiries Potential applicants send inquiries NIH Program Contacts well NSF contacts named the solicitation NSF-12-499). Karin Remington PhD Director, Division Biomedical Technology, Bioinformatics, Computational Biology National Institute General Medical Sciences  (301) 451-6446 remingka@nigms.nih.gov