Agenda

All times are Eastern Standard Time (EST)

Tuesday February 28, 2023
Welcome and Opening Remarks	10:00 AM Welcome to the NINDS Workshop on Status Epilepticus Walter J. Koroshetz, MD Director, National Institute of Neurological Disorders and Stroke (NINDS) 10:10 AM Shardell Spriggs, PhD Program Director, NIH Countermeasures Against Chemical Threats (CounterACT) 10:20 AM Vicky Whittemore, PhD Program Director, NINDS Division of Neuroscience
Patient Advocate Address	10:30 AM The Family Perspective of Status Epilepticus(pdf, 1327 KB) Nora Wong, PhD Executive Director, The NORSE Institute
Keynote Addresses	10:45 AM From Terrorists, Without Love: Nerve Agent-Induced Status Epilepticus and its Treatment(pdf, 2102 KB) Jonathan Newmark, MD Senior Medical Advisor, Office of Biodefense Research and Surety National Institute of Allergy and Infectious Diseases (NIAID) 11:10 AM Benzodiazepine-Refractory Status Epilepticus: Mechanisms and Treatment(pdf, 4470 KB) Jaideep Kapur, MBBS, PhD Eugene Meyer III, Professor of Neuroscience and Neurology Director, University of Virginia, Brain Institute 11:35 AM Q & A 11:45 AM BREAK (30 Minutes)
Clinical Unmet Needs and Current Clinical Research Moderators: Adam Hartman, MD, Program Director, Division of Clinical Research, NINDS and Shardell Spriggs, PhD	12:15 PM Clinical Unmet Needs in Refractory Status Epilepticus, including SRSE and NORSE(pdf, 3494 KB) Lawrence J. Hirsch, MD Professor of Neurology, Yale School of Medicine Chief, Division of Epilepsy and EEG Co-Director, Comprehensive Epilepsy Center and Continuous EEG Monitoring Program 12:35 PM Clinical Trials of Emergency Treatments for Status Epilepticus Robert Silbergleit, MD Professor of Emergency Medicine University of Michigan Medical School 12:55 PM Ganaxolone in Refractory Status Epilepticus Maciej Gasior, MD, PhD Vice President, Clinical Development Marinus Pharmaceuticals, Inc. 1:20 PM Q & A 1:30 PM BREAK (15 Minutes)
Patient Advocate Address	1:45 PM Short and Long-term Effects of Acute Organophosphorus Pesticide Self-poisoning(pdf, 1558 KB) Nicholas Buckley, MD South Asian Clinical Toxicology Research Collaboration Professor of Clinical Pharmacology, University of Sydney
Breakout Sessions	2:00 PM Parallel Sessions: Breakout 1: Refractory SE, Super-refractory SE, and New Onset Refractory SE Moderators: Lawrence J. Hirsch, MD Yale School of Medicine Howard P. Goodkin, MD, PhD, University of Virginia Health Breakout 2: Long-term Sequalae after Status Epilepticus Moderator: Sara E. Hocker, MD, Mayo Clinic Breakout 3: Unmet Needs in Clinical Trials (Rampart / ESETT) Moderator: Jaideep Kapur, MBBS, PhD, University of Virginia, Brain Institute 2:45 PM Workshop BREAK and Time for Synthesis of Breakout Reports (30 Minutes) 3:15 PM Reports from Breakout Sessions and Q & A
Poster Session	4:00 PM Transition to ePoster Session, Gather Town 5:00 PM Adjourn

Wednesday March 1, 2023
Welcome and Opening Remarks	10:00 AM Shardell Spriggs, PhD Program Director, NIH Countermeasures Against Chemical Threats (CounterACT)
Translational and Preclinical Unmet Needs and Current Research, Part I Moderators: Vicky Whittemore, PhD and Shardell Spriggs, PhD	10:15 AM Epilepsy Therapy Screening Program Yogi Raol, PhD Scientific Project Manager, NINDS Epilepsy Therapy Screening Program (ETSP) 10:30 AM U.S. Military Needs for Clinical Management of Benzodiazepine-Refractory Status Epilepticus Following Nerve Agent Exposure Anthony Cardile, DO, FACP Medical Officer, JPM CBRN Medical 10:45 AM Rapid Acquisition and Investigation of Drugs for Repurposing (RAIDR): Progress and Ambition(pdf, 2722 KB) Lauren Quattrochi, PhD Program Officer, Joint Program & Executive Office - CBRN Medical 11:00 AM A Rat Model of Super-refractory Status Epilepticus(pdf, 4310 KB) Hilary McCarren, PhD Research Neuroscientist, US Army Medical Research Institute of Chemical Defense 11:20 AM Pharmacoresistant Status Epilepticus – Combination Therapy, Long-term Effects and Alternative Animal Models Lucille Lumley, PhD Principal Investigator, US Army Medical Research Institute of Chemical Defense 11:40 AM Q & A 11:50 AM BREAK (30 Minutes)
Keynote Addresses	12:20 PM Preclinical Research Gaps in Chemical-Induced Seizures(pdf, 1420 KB) Pamela Lein, PhD Professor of Neurotoxicology, Chair, Department of Molecular Biosciences Director, UC Davis CounterACT Center of Excellence University of California, Davis, School of Veterinary Medicine 12:45 PM How Understanding the Sequelae of Acute Chemical Threat Intoxication can Inform Therapeutic Development for Epilepsy Amy Brooks-Kayal, MD Professor and Chair, Department of Neurology Co-Director, UC Davis CounterACT Center of Excellence University of California, Davis, School of Medicine 1:10 PM Q & A 1:20 PM BREAK (10 Minutes)
Translational and Preclinical Unmet Needs and Current Research, Part II	1:30 PM The Superior Neuroprotective Efficacy of Antiglutamatergic Therapy as First-Line Treatment Against Nerve Agent-Induced Status Epilepticus Maria Braga, DDS, PhD Professor of Anatomy, Physiology and Genetics School of Medicine, Uniformed Services University of the Health Sciences 1:50 PM Therapeutic Approaches for Treating Organophosphate-induced Status Epilepticus Co-morbidities, Based on Changes in Calcium Homeostasis Laxmikant Deshpande, PhD Associate Professor of Neurology, Pharmacology and Toxicology School of Medicine, Virginia Commonwealth University 2:10 PM Ganaxolone as a Neurosteroid Anticonvulsant for OP Refractory Status Epilepticus: A Decade-Long Journey to Bring it from Bench to Clinic D. Samba Reddy, PhD Regents Professor, Department of Neurosciences and Experimental Therapeutics Director, Institute of Pharmacology and Neurotherapeutics, Texas A&M College of Medicine 2:30 PM Status Epilepticus: View from the Bench Douglas A. Coulter, PhD Professor, Departments of Pediatrics and Neuroscience University of Pennsylvania, Perelman School of Medicine and the Research Institute at the Children’s Hospital of Philadelphia 2:45 PM Real World Implementation of Status Epilepticus Care: Seizing an Opportunity for Improvement Elan Guterman, MD, MAS Assistant Professor, Department of Neurology Affiliate Faculty, UCSF Philip R. Lee Institute for Health Policy Studies University of California, San Francisco 3:00 PM Q & A 3:15 PM BREAK (15 Minutes)
Breakout Sessions	3:30 PM Parallel Sessions: Breakout 4: Animal Models for Therapeutic Development Moderators: Hilary McCarren, PhD, US Army Medical Research Institute of Chemical Defense Maria Braga, DDS, PhD, School of Medicine, Uniformed Services University of the Health Sciences Breakout 5: Considerations for Academic Engagement and Regulatory Pathways Moderator: O’Neill D’Cruz, MD, MBA, FAAN, OD Consulting and Neurological Services, PLLC Breakout 6: Barriers in Translational Research Studies and Therapeutic Advancement Moderators: Michael A. Rogawski, MD, PhD, University of California, Davis James Cloyd III, PharmD, University of Minnesota 4:15 PM Workshop BREAK and Time for Synthesis of Breakout Reports (30 Minutes) 4:45 PM Reports from Breakout Sessions and Q & A
Closing Remarks and Adjournment	5:30 PM Shardell Spriggs, PhD Program Director, NIH Countermeasures Against Chemical Threats (CounterACT)