Press Releases


New NIH-funded memory drug moves into Phase 1 clinical study

Thursday, December 31, 2015

An experimental drug that may improve memory is now being tested in a Phase 1 safety trial. The compound, BPN14770, was developed by Tetra Discovery Partners, with support from the NIH Blueprint Neurotherapeutics Network, a program designed to facilitate the discovery and development of novel...

Using mouse brains, scientists studied the role of the proteasome system in neurodegenerative disorders.

Speeding up brain's waste disposal may slow down neurodegenerative diseases

Monday, December 21, 2015

A study of mice shows how proteasomes, a cell's waste disposal system, may break down during Alzheimer's disease (AD), creating a cycle in which increased levels of damaged proteins become toxic, clog proteasomes, and kill neurons. The study, published in Nature Medicine and supported by the...

Scientists studied how the thalamus tunes brain activity during different states of consciousness in rats.

Scientists manipulate consciousness in rats

Friday, December 18, 2015

Scientists showed that they could alter brain activity of rats and either wake them up or put them in an unconscious state by changing the firing rates of neurons in the central thalamus, a region known to regulate arousal. The study, published in eLIFE, was partially funded by the National...

Scientists reduced levels of BRCA1 in mouse brains and in neurons in a dish to investigate the role of the protein in dementia.

DNA repair factor linked to breast cancer may also play a role in Alzheimer's disease

Monday, November 30, 2015

Mutant forms of breast cancer factor 1 (BRCA1) are associated with breast and ovarian cancers but according to new findings, in the brain the normal BRCA1 gene product may also be linked to Alzheimer's disease. The results, published in Nature Communications, suggest that low levels of BRCA1...

Scientists mapped the brain circuits that allow flies to react to temperature changes.

Study shows how fruit flies beat the heat (and cold)

Monday, November 23, 2015

Humans aren't the only ones that take shelter when the weather turns unpleasant. A team of researchers at Northwestern University's Department of Neurobiology has mapped the neural circuits that allow flies to avoid uncomfortable temperatures.

Injecting a shot of genes into the brain’s ventricular plumbing system may be an effective long term method for treating neurological disorders.

Batten disease may benefit from gene therapy

Wednesday, November 11, 2015

In a study of dogs, scientists showed that a new way to deliver replacement genes may be effective at slowing the development of childhood Batten disease, a rare and fatal neurological disorder.

Adding GDF10 to neurons in a dish results in the formation of new connections between brain cells. This process may lead to recovery after stroke.

Scientists identify main component of brain repair after stroke

Wednesday, October 28, 2015

Looking at brain tissue from mice, monkeys and humans, scientists have found that a molecule known as growth and differentiation factor 10 (GDF10) is a key player in repair mechanisms following stroke. The findings suggest that GDF10 may be a potential therapy for recovery after stroke. The...

Scientists discovered how a pair of proteins work together to produce chronic itch.

An itch you just can't scratch

Tuesday, October 27, 2015

Everyone knows the best way to suppress an itch is to scratch it, but for people who suffer from skin diseases like eczema, no amount of scratching can bring relief. Fortunately, help may be on the way. Scientists from the Buck Institute for Research on Aging and the University of California,...

Scientists mapped out the brain circuitry that helps mice focus.

Study in mice shows how brain ignores distractions

Wednesday, October 21, 2015

In a study of mice, scientists discovered that a brain region called the thalamus may be critical for filtering out distractions. The study, published in Nature and partially funded by the National Institutes of Health, paves the way to understanding how defects in the thalamus might underlie...

A genetic mutation implicated in ALS and FTD prevents proteins (green) from entering and exiting the cell’s nucleus (pink).

Nuclear transport problems linked to ALS and FTD

Friday, October 16, 2015

Three teams of scientists supported by the National Institutes of Health showed that a genetic mutation linked to some forms of amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD) may destroy neurons by disrupting the movement of materials in and out of the cell's nucleus,...