Grantees in the News

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Novel gene variants that modify risk of late-onset Alzheimer’s disease discovered

Baylor College of Medicine and Texas Children’s Hospital
Monday, December 7, 2020

Researchers at Baylor College of Medicine and Texas Children’s Hospital have now identified more than 200 new gene variants believed to play a role in who is affected by Late-onset Alzheimer’s disease (LOAD).

Research unlocks new information about reading through visual dictionary in the brain

The University of Texas Health Science Center at Houston
Monday, November 30, 2020

Scientists at The University of Texas Health Science Center at Houston (UTHealth) have now identified a crucial region in the temporal lobe, know as the mid-fusiform cortex, which appears to act as the brain’s visual dictionary.

Genetic treatment plus exercise reverses fatigue in mice with muscle wasting disease

Massachusetts General Hospital
Monday, November 30, 2020

Adding exercise to a genetic treatment for myotonic dystrophy type 1 (DM1) was more effective at reversing fatigue than administering the treatment alone in a study using a mouse model of the disease. In fact, exercise alone provided some benefit whereas the genetic treatment alone did not.

Cortex over reflex: Study traces circuits where executive control overcomes instinct

The Picower Institute for Learning and Memory at MIT
Monday, November 30, 2020

When riding your bike to the store you might have two very different reasons to steer: plain old reflex when you see something dart into your path, or executive control when you see street signs that indicate the correct route. A new study by MIT neuroscientists shows how the brain is wired for both by tracking the specific circuits involved and their effect on visually cued actions.

Penn Medicine Researchers Unlock the Door to Tumor Microenvironment for CAR T Cells

Perelman School of Medicine at the University of Pennsylvania
Monday, November 30, 2020

The labyrinth of jumbled blood vessels in the tumor microenvironment remains one of the toughest blockades for cellular therapies to penetrate and treat solid tumors. Now, in a new study published online today in Nature Cancer, Penn Medicine researchers found that combining chimeric antigen receptor (CAR) T cell therapy with a PAK4 inhibitor drug allowed the engineered cells to punch their way through and attack the tumor, leading to significantly enhanced survival in mice.

AI helps scientists understand brain activity behind thoughts

Baylor College of Medicine
Monday, November 23, 2020

A team led by researchers at Baylor College of Medicine and Rice University has developed artificial intelligence (AI) models that help them better understand the brain computations that underlie thoughts.

Early details of brain damage in COVID-19 patients

Massachusetts General Hospital
Wednesday, November 18, 2020

Study finds COVID-19 patients with neurological symptoms show some of the same disturbances in the brain as other patients who have suffered oxygen deprivation from other causes, but there are also notable differences.

Can high-intensity exercise slow Parkinson’s?

Northwestern University Feinberg School of Medicine
Wednesday, November 18, 2020

Trial tests if high- or moderate-intensity exercise is more effective in decreasing Parkinson’s symptoms.

Promising MS drug could worsen disease, UVA research suggests

University of Virginia School of Medicine
Friday, November 13, 2020

A drug that has shown promise for treating multiple sclerosis may actually make the debilitating disease worse, new research from the University of Virginia School of Medicine suggests. 

Astrocytes identified as master ‘conductors’ of the brain

Duke University
Thursday, November 12, 2020

Star-shaped ‘glue’ cells make it their business to govern connections between neurons.