Grantees in the News

Grantees in the News

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Researchers Provide Complete Clinical Landscape for Major Gene Linked to Epilepsy and Autism

Children’s Hospital of Philadelphia
Wednesday, March 17, 2021

Researchers from Children’s Hospital of Philadelphia (CHOP) affiliated with the CHOP Epilepsy Neurogenetics Initiative (ENGIN) have compiled a complete genetic and clinical analysis of more than 400 individuals with SCN2A-related disorder, which has been linked to a variety of neurodevelopmental disorders, including epilepsy and autism. By linking clinical features to genetic abnormalities in a standardized format, the researchers hope their findings lead to improved identification and clinical intervention.

Sleep Apnea Not Associated with Wake-Up Stroke

University of Michigan Medicine
Monday, March 15, 2021

Stroke onset while asleep does not seem to be the direct link between sleep apnea and stroke.

UAB researchers identify potential therapeutic target against malignant brain tumors

University of Alabama at Birmingham
Monday, March 15, 2021

Researchers at the University of Alabama at Birmingham have identified a potential new pathway to treating radiation-resistant glioblastoma, one of the most aggressive forms of brain cancer. 

New study provides insights into architecture of abnormal protein deposits in brain disorders

Case Western Reserve University School of Medicine
Friday, March 12, 2021

Scientists at the Case Western Reserve University School of Medicine have determined the structure of protein “fibrils” linked to Lou Gehrig’s disease and other neurodegenerative disorders—findings that provide clues to how toxic proteins clump and spread between nerve cells in the brain.

New Spherical Nucleic Acid ‘Drug’ Kills Tumor Cells in Humans With Glioblastoma

Northwestern University Feinberg School of Medicine
Wednesday, March 10, 2021

Early clinical trial shows experimental drug crosses blood-brain barrier to trigger death of brain tumor cells.

Riding the wave to memory-forming genetics

UT Southwestern Medical Center
Wednesday, March 10, 2021

Study identifies the key genes in the brain involved in encoding memories.

Study Maps Key Proteins Linked to Epilepsy, Revealing New Drug Targets

NYU Langone Health
Tuesday, March 9, 2021

An analysis of adult human brain tissue reveals over 900 proteins tied to epilepsy. 

CBD reduces plaque, improves cognition in model of familial Alzheimer’s

Medical College of Georgia at Augusta University.
Monday, March 8, 2021

A two-week course of high doses of CBD helps restore the function of two proteins key to reducing the accumulation of beta-amyloid plaque, a hallmark of Alzheimer’s disease, and improves cognition in an experimental model of early onset familial Alzheimer’s, investigators report.

Huntington’s disease may be driven by slowed protein-building machinery in cells

Scripps Research
Friday, March 5, 2021

A new study shows that mutant huntingtin proteins slow ribosomes.

Scientists Find New Cell Type Implicated in Chronic Pain, Inflammation

UNC School of Medicine
Thursday, March 4, 2021

The discovery, from the UNC School of Medicine lab of Mark Zylka, PhD, offers pain researchers a new, precise target to treat inflammation associated with neuropathic pain.