Webinar: Discuss New Funding Announcement - Stroke Preclinical Assessment Network (SPAN) to Support Translational Studies for Acute Neuroprotection

Webinar: Discuss New Funding Announcement - Stroke Preclinical Assessment Network (SPAN) to Support Translational Studies for Acute Neuroprotection

September 18, 2018
September 18, 2018

Location: 

Webinar
1-2:30 p.m.m EST
Phone number: 1-650-479-3208
Access # 620 311 854
Password #1234

Event Description: 

Join the webinar event on September 18, 2018 from 1:00 p.m. - 2:30 p.m. EST to discuss new funding opportunity announcements: RFA-NS-18-033 and RFA-NS-18-034 on the Stroke Preclinical Assessment Network.

View webinar slides (pdf, 1068 kb)

(Application due date December 13, 2018)

  • RFA-NS-18-033 - Stroke Preclinical Assessment Network (SPAN) to Support Translational Studies for Acute Neuroprotection (U01 Clinical Trial Not Allowed)

    The purpose of this funding opportunity announcement (FOA) is to solicit applications of promising neuroprotective drugs/interventions for the Stroke Preclinical Assessment Network (SPAN).  SPAN will support late-stage preclinical studies of putative neuroprotectants to be given prior to or at the time of reperfusion, with clinically relevant long-term outcomes and comorbidities. Parallel testing of the most promising interventions will help to determine if an intervention can improve outcome as compared to reperfusion alone and/or extend the therapeutic window for reperfusion, and if so, guide the selection of the best agent(s) to transition to future Phase II clinical trials (to be conducted through StrokeNet).  SPAN will consist of one Coordinating Center (CC) and up to 6 network sites; this infrastructure is expected to test up to 6 compounds/interventions (one for each of the awarded sites) in animal models of transient cerebral ischemia. The SPAN program will not support any human subjects research.
     
  • RFA-NS-18-034 - Stroke Preclinical Assessment Network (SPAN) to Support Translational Studies for Acute Neuroprotection - Coordinating Center (U24 Clinical Trial Not Allowed)
    The purpose of this funding opportunity announcements (FOAs) issued by NINDS is to invite applications for the Coordinating Center and network sites for the NIH Stroke Preclinical Assessment Network (SPAN).  SPAN will facilitate testing of up to 6 promising neuroprotective drugs or interventions to be given prior to or at the time of reperfusion in experimental models of ischemic stroke (e.g., transient middle cerebral artery occlusion). The awarded network sites will become part of the network and will collaborate with the other awarded sites under the oversight and central coordination provided by the SPAN Coordinating Center.  Applicants for the network sites must propose a promising neuroprotective intervention to be tested within SPAN; awarded sites must agree to  test up to 6 interventions in parallel, including their own. If successful, this network will accelerate the identification of the most promising neuroprotective therapies for future pivotal clinical trials and span the gap between preclinical and clinical testing, in a cost-and time-effective fashion.

 

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