Ketema N. Paul, Ph.D.

Ketema N. Paul, Ph.D.

Speech Title: "Becoming a Biomedical Scientist: Challenges and Rewards"Ketema N. Paul

Dr. Ketema Paul, Associate Professor of Neurobiology at the Morehouse School of Medicine (MSM), studies the genetic, molecular, and neural underpinnings of the sleep-wake cycle. His primary interests are comprised of uncovering the mechanisms responsible for the negative effects of sleep deprivation and developing biomarkers for sleep loss. He also probes the origins of gender differences in the ability to recover from sleep loss. Dr. Paul was born and raised in Washington, D.C. After receiving a bachelor’s degree in biology from Howard University he went on to study neurobiology and circadian biology at Georgia State University in Atlanta, Georgia, where he received his doctorate in 2003. Dr. Paul completed a postdoctoral fellowship at Northwestern University in Evanston, Illinois in 2006 at the Center for Sleep and Circadian Biology, after which he accepted a faculty position at the MSM. He has published extensively in well-regarded journals and has received a number of awards and accolades for his research program. His current research involves applying a forward genetics approach to uncover the core genes responsible for sleep-wake regulation and the impairing effects of sleep loss. Effective treatments for common sleep-wake disorders have been elusive. Dr. Paul conducts a forward genetics approach to facilitate gene identification that takes advantage of natural variation occurring in sleep-replete and sleep-deprived mice. This approach applies the most cutting-edge genome haplotype mapping, positional cloning, and DNA sequencing techniques to identifying the genetic origins of unique sleep phenotypes in transgenic mouse models. These studies are expected to identify novel sleep regulatory genes and lead to the development of new therapeutic targets and improved treatments for sleep disorders.