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Support of Competitive Research (SCORE) Research Advancement Award (SC1)

PAR
Wednesday, September 21, 2016
Workforce Diversity
Sunday, September 8, 2019
PAR-16-439

Funding Opportunity Purpose

The SCORE Program is a developmental program designed to increase the research competitiveness of faculty and the research base at institutions with an explicitly stated historical mission and/or a demonstrated historical track record of training and graduating students from backgrounds underrepresented in biomedical research. Eligible institutions must award science degrees to undergraduate (B.S. or B.A.) and/or graduate students (M.S. or Ph.D.) and have received less than 6 million dollars per year of NIH R01 support (total costs) in each of the last 2 fiscal years.

Engineering Next-Generation Human Nervous System Microphysiological Systems (R01)

PAR
Thursday, August 11, 2016
Wednesday, January 8, 2020
R01
PAR-16-398

Funding Opportunity Purpose

This Funding Opportunity Announcement (FOA) encourages research grant applications directed toward developing next-generation human cell-derived microphysiological systems (MPS) with improved fidelity to complex human brain, spinal, peripheral nervous system and/or sensory end organ circuit physiology in vivo, which will ultimately facilitate analysis of higher order functional deficits relevant to complex nervous system disorders.

Engineering Next-Generation Human Nervous System Microphysiological Systems (R21)

PAR
Thursday, August 11, 2016
Wednesday, January 8, 2020
R21
PAR-16-397

Funding Opportunity Purpose

This Funding Opportunity Announcement (FOA) encourages research grant applications directed toward developing next-generation human cell-derived microphysiological systems (MPS) with improved fidelity to complex human brain, spinal, peripheral nervous system and/or sensory end organ circuit physiology in vivo, which will ultimately facilitate analysis of higher order functional deficits relevant to complex nervous system disorders.

Countermeasures Against Chemical Threats (CounterACT): Identification of Therapeutic Lead Compounds (U01)

PAR
Wednesday, June 15, 2016
Translational Research
Wednesday, September 12, 2018
U01
PAR-16-330
David A. Jett

Funding Opportunity Purpose

The mission of the NIH Countermeasures Against Chemical Threats (CounterACT) program is to develop new and improved therapeutics to treat and/or prevent injuries resulting from exposure to chemical threats. Chemical threats are toxic chemicals that could be used in a terrorist attack or accidentally released from industrial production, storage or shipping. They include traditional chemical warfare agents and toxic industrial chemicals and materials. This Funding Opportunity Announcement (FOA) requests new research applications for Cooperative Agreement Research Projects (U01s) seeking support for research on the identification of small molecule or biologic lead compounds that are excellent candidates for therapeutic development. The scope of research supported by this FOA includes confirmation of molecular targets for therapeutic development, demonstration of in vitro activity of candidate therapeutics, preliminary in vivo proof-of-concept efficacy data, preliminary adsorption, distribution, metabolism, excretion, and toxicity (ADME/Tox) evaluations and pharmacokinetics/pharmacodynamics (PK/PD) data. These studies should result in the identification of at least one lead compound ready for optimization. Lead compounds are biologically active and synthetically feasible compounds where specificity, affinity, potency, target selectivity, efficacy, and safety have been established. Lead compounds should be ready for more advanced development under possible support from other programs such as the one described in the companion FOA "CounterACT Optimization of Therapeutic Lead Compound (U01)" (PAR-16-331). The scope of this FOA encompasses Technical Readiness Level (TRL) 3 - see TRLs. Each project must include annual milestones that create discrete go or no-go decision points in a progressive translational study plan.

Countermeasures Against Chemical Threats (CounterACT): Optimization of Therapeutic Lead Compounds (U01)

PAR
Wednesday, June 15, 2016
Translational Research
Wednesday, September 12, 2018
U01
PAR-16-331
David A. Jett

Funding Opportunity Purpose

The mission of the NIH Countermeasures Against Chemical Threats (CounterACT) program is to develop new and improved therapeutics to treat and/or prevent injuries resulting from exposure to chemical threats. Chemical threats are toxic chemicals that could be used in a terrorist attack or accidentally released from industrial production, storage or shipping. They include traditional chemical warfare agents and toxic industrial chemicals and materials. This Funding Opportunity Announcement (FOA) requests research applications seeking support for research on the optimization of small molecule or biologic compounds that are excellent candidates for therapeutic development. A previously identified lead compound is required to be eligible for this funding opportunity. In this regard, lead compounds are defined as biologically active compounds or hits where affinity, potency, target selectivity, and preliminary safety have been established. The scope of research supported by this FOA includes development of appropriate human-relevant animal models and generation of in vivo efficacy data consistent with the intended use of the product in humans. It also includes bioanalytical assay development and validation, laboratory-scale and scale-up manufacturing of the product, and non-GLP toxicity and pharmacology studies. The scope of this FOA encompasses Technical Readiness Levels (TRLs) 4-5 - see TRLs. Each project must include annual milestones that create discrete go or no-go decision points in a progressive translational study plan.

Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32)

PA
Friday, June 3, 2016
Training, Career Development
Wednesday, May 8, 2019
F32
PA-16-307

Funding Opportunity Purpose

The purpose of the Kirschstein-NRSA postdoctoral fellowship is to enhance the research training of promising postdoctoral candidates who have the potential to become productive, independent investigators in scientific health-related research fields relevant to the missions of the participating NIH Institutes and Centers.

Serious Adverse Drug Reaction Research (R01)

PAR
Thursday, May 19, 2016
Channels, Synapses, Circuits
Sunday, September 8, 2019
R01
PAR-16-275

Funding Opportunity Purpose

This Funding Opportunity Announcement is to support research grants that will advance the state of knowledge of serious adverse drug reactions. Applications across the spectrum of research are encouraged.

Serious Adverse Drug Reaction Research (R21)

PAR
Thursday, May 19, 2016
Sunday, September 8, 2019
R21
PAR-16-274

Funding Opportunity Purpose

This Funding Opportunity Announcement is to support research grants that will advance the state of knowledge of serious adverse drug reactions. Applications across the spectrum of research are encouraged.

Dissemination and Implementation Research in Health (R03)

PAR
Tuesday, May 10, 2016
Clinical Research
Wednesday, May 8, 2019
R03
PAR-16-237
Salina Waddy, M.D.

Funding Opportunity Purpose

This Funding Opportunity Announcement (FOA) encourages investigators to submit research grant applications that will identify, develop, evaluate and refine effective and efficient methods, systems, infrastructures, and strategies to disseminate and implement evidence-based health behavior change interventions, evidence-based prevention, early detection, diagnostic, treatment and management, and quality of life improvement services into public health, clinical practice, and community settings.

Neural Regulation of Cancer (R21)

PAR
Monday, May 9, 2016
Friday, June 28, 2019
R21
PAR-16-246

Funding Opportunity Purpose

This Funding Opportunity Announcement (FOA) encourages collaborative, transdisciplinary research with both neuroscience and cancer elements, which together will advance current understanding of the nervous system contribution to cancer. Leveraging the knowledge, tools, experimental models and reagents in neuroscience research to uncover novel mechanisms used by the nervous system to promote tumor initiation, progression and metastasis can ultimately inform key areas of cancer research including the prevention and treatment of non-central nervous system tumors.

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