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Discontinuation PAR-13-022 NINDS Cooperative Program Translational Research U01)" Notice Number: NOT-NS-14-013 Key Dates Release Date: February 13, 2014 Related Announcements PAR-13-022 Issued National Institute Neurological Disorders Stroke NINDS) Purpose Notice to inform potential applicants NINDS discontinue PAR-13-022 quot;NINDS Cooperative Program Translational Research U01)." Applications not accepted NINDS this Funding Opportunity Announcement after February 7, 2014 application due date.  Notices announcing related new programs be forthcoming. Inquiries Please direct inquiries to: Linda McGavern, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: CREATEinquiries@mail.nih.gov nbsp;

Request Information RFI): Areas Research Aimed a Cure Lifelong Remission HIV Infection Notice Number: NOT-AI-14-034 Update: following update relating this announcement been issued: February 21, 2014 - Notice NOT-AA-14-002. Notice NIAAA Participation. Key Dates Release Date: February 5, 2014 Response Date: March 14, 2014 Related Announcements None Issued National Institute Allergy Infectious Diseases NIAID) National Institute Alcohol Abuse Alcoholism NIAAA) National Cancer Institute NCI) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) NIH Office AIDS Research OAR) Purpose Commemorating World AIDS Day December 2, 2013, President Obama announced redirection 100 million expand support research aimed a cure lifelong remission HIV infection purpose this Request Information RFI) to seek input the scientific community regarding high priority research areas related HIV persistence the development strategies eradicating controlling virus remaining despite optimal antiretroviral treatment. information obtained responses aid NIH prioritizing areas be supported HIV cure-related research. Background HIV infection a disease is manageable lifelong effective antiretroviral therapy; however cure remains elusive. Despite prolonged suppression viral replication very low levels, antiretroviral therapy discontinued, viral replication rebounds pretreatment levels nearly infected persons. report a single case a cure an adult underwent stem cell transplants well the report an infant was cured HIV infection early treatment initiated the second day life renewed interest the field cure-related research highlighted need further basic research understand sources and reservoirs residual viremia, mechanisms facilitate persistence,  better assays evaluating measuring persistent HIV well evaluation therapeutic concepts targeting residual virus. Currently, broad program cure-related research supported across NIH.  research spans Institutes addresses range issues, including basic science, adult pediatric research, neuroAIDS. funds available through President’s directive offers NIH opportunity expand research opportunities. Input the research community important identify those research areas highest priority warrant additional support. Information Requested RFI invites scientific community provide comments can include are limited the following areas: 1. a) HIV cure-related research topics should considered high priority.    b) new basic information, technologies, resources are needed facilitate progress this area.    2. a) Areas cure-related research, any, should considered lower priority.   b) approaches have already been, are currently being, explored a sufficient level. 3. a) balance point between basic, translational clinical evaluations would provide optimal mix rapidly advance cure research.    b) type expertise should included enhance better enable research toward cure. c) new initiatives are needed on topics should focus.    d) grant mechanisms would most appropriate.   4. a) Any existing initiatives cure-related programs should expanded abolished.    b) existing programs currently not include cure-related research could logically expanded include cure-related research part the scope. Responses Responses be accepted through March 14, 2014. Please respond email to: CureRFI@nih.gov include text RFI Reply” the subject line. Please specify area are providing responses to. Only submissions this email address be considered this RFI. Please limit total response a maximum 3 pages. interested extramural investigators other interested parties invited respond. Responders free address any all the above items.  individual responses remain confidential. Any identifiers e.g., names, institutions, email addresses, etc.) be removed responses compiled. Only processed, anonymized results be shared internally NIH staff members, appropriate. U.S. Government cannot guarantee confidentiality the information provided. Responders advised the U.S. Government under obligation acknowledge receipt the information received provide feedback responders respect any information submitted. RFI for information planning purposes only should be construed a solicitation applications as obligation the part the U.S. Government provide support any ideas identified response it.  U.S. Government not pay the preparation any information submitted for use that information. Responders should aware the information provided be analyzed may used develop future funding opportunity announcements and/or appear various reports. Inquiries Responses this RFI should only submitted the email address noted above Responses”.  Questions this RFI be directed any the NIH staff members listed below: Paul Sato, M.D. Office AIDS Research Telephone:   301-480-2330  Email:  paul.sato@nih.gov Diana Finzi, Ph.D. National Institute Allergy Infectious Diseases NIAID) Telephone:   301-451-2598 Email: dfinzi@niaid.nih.gov Sarah Read, M.D. National Institute Allergy Infectious Diseases NIAID) Telephone:   301-451-2757 Email: readsa@niaid.nih.gov Katherine Davenny, M.P.H. National Institute Drug Abuse NIDA) Telephone:   301-443-2146 Email: kdavenny@nida.nih.gov Rohan Hazra, M.D. Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) Telephone:  301-435-6868 Email:  hazrar@mail.nih.gov Stephen Hughes, Ph.D. National Cancer Institute NCI) Telephone:  301-846-1619 E-mail: hughesst@mail.nih.gov Jeymohan Joseph, Ph.D. National Institute Mental Health NIMH) Telephone: 301-443-3012 Email: jjeymoha@mail.nih.gov Wong, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1431 Email: wongm@ninds.nih.gov  

Notification a Change Funding Level NINDS Research Education Programs Residents Fellows Neurology, Neurosurgery, Neuropathology Neuroradiology R25) Notice Number: NOT-NS-14-010 Key Dates Release Date: January 30, 2014 Related Announcements RFA-NS-09-001 RFA-NS-10-002 NOT-NS-12-022 PAR-13-384 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to inform those holding active grants were funded under of three Funding Opportunity Announcement FOAs) mentioned below that, effective immediately, administrative supplement support FY 2014 participants conform the budgetary allowances described participants PAR-13-384. NINDS issued three FOAs RFA-NS-09-001, RFA-NS-10-002, RFA-NS-12-003) encourage submission administrative supplements support residents fellows Neurology, Neurosurgery, Neuropathology Neuroradiology conduct research. these three FOAs, direct cost allowed each participating resident fellow limited 70,000. November 2013, NINDS published new FOA PAR-13-384) continuation this program. Because participant's salary fringe requirements exceed 70,000 direct cost maximum, new FOA omitted dollar amount cap direct cost support each individual participant. new FOA supports resident fellow salary fringe benefits to 80% the institution's PGY amount relevant that participant, commensurate the duration the participant's commitment the R25 program activities. addition, additional 3,000 per participant provided travel a scientific meeting an NINDS-sponsored workshop, up 10,000 per year provided per program year administrative costs. Inquiries Please direct inquiries to: Stephen Korn, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-4188 Email: korns@ninds.nih.gov nbsp;

Notice Correction NINDS's CFDA number PAR-13-278 NINDS Phase III Investigator-Initiated Efficacy Clinical Trials U01)" Notice Number: NOT-NS-14-008 Update: following update relating this announcement been issued: March 4, 2014 - Notice NOT-NS-14-017. Notice Correct NINDS CFDA Number Associated this FOA, new application package been posted. Key Dates Release Date: January 16, 2014 Related Announcements PAR-13-278 Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS) correcting CFDA number associated PAR13-278 NINDS Phase III Investigator-Initiated Efficacy Clinical Trials U01)". CFDA number should read: Catalog Federal Domestic Assistance CFDA) Number(s) 93.853 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Wendy Galpern, MD, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9135 Email: Phase3Trial@ninds.nih.gov  

Request Information RFI): Input the European Multi-PART Multicenter Preclinical Animal Research Team) planning effort generate international preclinical stroke network infrastructure Notice Number: NOT-NS-14-006 Key Dates Release Date: January 16, 2014 Response Date: February 7, 2014 Related Announcements None Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS) requesting opinions the US stroke research community regarding European Multi-PART Multicenter Preclinical Animal Research Team; www.multi-part.org) initiative.  Background Multi-PART a planning effort intended generate infrastructure an international preclinical stroke network. overall objective to develop capacity undertake international multicenter animal studies improve validity generalizability current preclinical research. consortium, group internationally recognized scientists broad comprehensive expertise, proposes perform preclinical studies the same rigor centralized coordination characterize multicenter Phase III randomized controlled clinical trials humans. Creating such network identified a cross-cutting priority the 2012 NINDS Stroke Research Priorities Meeting http://www.ninds.nih.gov/find_people/ninds/OSPP/Stroke-Research-Priorit…, a description the recommendations developed that conference). Request Information Investigators actively conducting stroke research encouraged provide brief description to exceed 2 pages) their view regarding benefits risks US stroke investigators participating Multi-PART, area(s) expertise stroke research, potential contribution the Multi-PART planning effort. to Submit Response Responses be accepted through February 7th, 2014. Electronic responses preferred may addressed Multi-Part-Volunteers@ninds.nih.gov please include Notice number, NOT-NS-14-006, the subject line). Responses also sent letter fax the following address: Francesca Bosetti, Pharm.D., Ph.D. Program Director, Neural Environment Cluster National Institute Neurological Disorders Stroke National Institutes Health 6001 Executive Blvd. Rm. 2115 Bethesda, MD 20892-9521 Fax: 301-402-2060 Responses this RFI voluntary, will reviewed NINDS. RFI for planning purposes only, is a solicitation applications an obligation the part the United States U.S.) Government provide support any ideas identified response it. Please note the U.S. Government not pay the preparation any comment submitted, for use that comment. Inquiries Please direct inquiries to: Francesca Bosetti, Pharm.D., Ph.D. National Institute Neurological Disorders Stroke NINDS) Phone: 301-496-1431 Email: frances@mail.nih.gov nbsp;

Notice Correction NINDS's CFDA number PAR-13-281 NINDS Exploratory Clinical Trials R01)" Notice Number: NOT-NS-14-007 Update: following update relating this announcement been issued: March 3, 2014 - Notice NOT-NS-14-016. Notice Correct NINDS CFDA number associated PAR-13-281 NINDS Exploratory Clinical Trials R01)", new Application package been posted. Key Dates Release Date: January 16, 2014 Related Announcements PAR-13-281 Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS) correcting CFDA number associated PAR13-281 NINDS Exploratory Clinical Trials R01)". CFDA number should read: Catalog Federal Domestic Assistance CFDA) Number(s) 93.853 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Peter R. Gilbert, Sc.M. National Institute Neurological Disorders Stroke Telephone: 301-496-0870 Email: ExploratoryTrial@ninds.nih.gov  

Notice Informational Conference Calls Prospective Applicants NIH BRAIN Initiative Funding Opportunity Announcements Notice Number: NOT-NS-14-005 Key Dates Release Date: January 6, 2014 Related Announcements RFA-NS-14-007 RFA-NS-14-008 RFA-NS-14-009 RFA-MH-14-215 RFA-MH-14-216 RFA-MH-14-217 Issued NIH Blueprint Neuroscience Research http://neuroscienceblueprint.nih.gov) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) Purpose Background Information Brain Research through Advancing Innovative Neurotechnologies BRAIN) Initiative a new Presidential project aimed revolutionizing our understanding the human brain. accelerating development application innovative technologies, researchers be able produce new dynamic picture the brain that, the first time, shows individual cells complex neural circuits interact both time space. is expected the application these new tools technologies ultimately lead new ways treat, cure, even prevent brain disorders. general information inquiries regarding NIH support the BRAIN Initiative, please consult following website: http://www.nih.gov/science/brain/index.htm.  December 17, 2013, NIH released six Funding Opportunity Announcements FOAs) the inaugural set projects under BRAIN Initiative links the Related Announcements section this Notice), an expected initial investment 40M be considered NIH funding Fiscal Year 2014.  Summaries the FOAs other information prospective applicants available the following website: http://www.nih.gov/science/brain/funding.htm.  Informational Conference Calls purpose this Notice to inform prospective applications the FOAs NIH be hosting series informational conference calls address technical questions regarding applications each the FOAs.  Information dates contacts each the conference calls as follows: January 10, 2014, 2:00-3:00 PM EST: RFA-MH-14-215, Transformative Approaches Cell-Type Classification the Brain call-in information, contact Andrea Beckel-Mitchener BRAIN-info-NIMH@mail.nih.gov.  January 13, 2014, 2:00-3:00 PM EST: RFA-MH-14-216, Development Validation Novel Tools Analyze Cell-Specific Circuit-Specific Processes the Brain call-in information, contact Michelle Freund BRAIN-info-NIMH@mail.nih.gov.  January 15, 2014, 1:00-2:00 PM EST: RFA-MH-14-217, Planning Next Generation Human Brain Imaging call-in information, contact Greg Farber BRAIN-info-NIMH@mail.nih.gov.  February 4, 2014, 1:00-2:30 PM EST: RFA-NS-14-007, New Technologies Novel Approaches Large-Scale Recording Modulation the Nervous System RFA-NS-14-008, Optimization Transformative Technologies Large Scale Recording Modulation the Nervous System RFA-NS-14-009, Integrated Approaches Understanding Circuit Function the Nervous System call-in information, contact Karen David NINDS-Brain-Initiative@nih.gov.  addition accessing information provided the upcoming conference calls, applicants strongly encouraged consult the Scientific/Research Contacts listed each the FOAs discuss alignment their proposed work the goals the FOA which intend apply. Inquiries Inquiries specifically regarding Notice be directed to: Edmund Talley, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301- 496-1917 Email: NINDS-Brain-Initiative@nih.gov nbsp;

Notice Extension Expiration date PA-11-180 Research Ethical Issues Biomedical, Social Behavioral Research R01)” Notice Number: NOT-OD-14-031 Key Dates Release Date: December 13, 2013 Related Announcements PA-11-180 Issued National Institutes Health NIH) National Cancer Institute NCI) National Human Genome Research Institute NHGRI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Allergy Infectious Diseases NIAID) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute General Medical Sciences NIGMS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) National Center Complementary Alternative Medicine NCCAM) Office Behavioral Social Sciences Research OBSSR) Purpose purpose this Notice to inform interested applicants the expiration date PA-11-180 quot;Research Ethical Issues Biomedical, Social Behavioral Research R01)" being extended until 8, 2015.  the exception NHLBI will continue participating, remaining participating NIH Institutes, Centers Offices ICOs) the same described the FOA.  Please note the mission statement the National Center Complementary Alternative Medicine NCCAM) is listed Part 2, Section Funding Opportunity Description under quot;NIH IC Mission Areas:" been changed the following: mission NCCAM to define, through rigorous scientific investigation, usefulness safety complementary alternative medicine interventions their roles improving health and health care. Inquiries information the FOA, prospective applicants should contact Scientific/Research Contact the relevant NIH ICO identified the end the FOA. General inquiries the FOA about extension Notice, be directed to: Ann Hardy Office Extramural Programs Telephone:  301-435-2690 Email: hardyan@od.nih.gov nbsp;

Notice Extension Expiration date PA-11-182 Research Ethical Issues Biomedical, Social Behavioral Research R21)" Notice Number: NOT-OD-14-033 Key Dates Release Date: December 13, 2013 Related Announcements PA-11-182 Issued National Institutes Health NIH) National Cancer Institute NCI) National Human Genome Research Institute NHGRI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Allergy Infectious Diseases NIAID) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Dental Craniofacial Research NIDCR) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) National Center Complementary Alternative Medicine NCCAM) Office Behavioral Social Sciences Research OBSSR) Purpose purpose this Notice to inform interested applicants the expiration date PA-11-182 quot;Research Ethical Issues Biomedical, Social Behavioral Research R21)" being extended until 8, 2015.  the exception NHLBI will continue participating, remaining participating NIH Institutes, Centers Offices ICOs) the same described the FOA.  Please note the mission statement the National Center Complementary Alternative Medicine NCCAM) is listed Part 2, Section Funding Opportunity Description under quot;NIH IC Mission Areas" been changed the following: mission NCCAM to define, through rigorous scientific investigation, usefulness safety complementary alternative medicine interventions their roles improving health and health care. Inquiries information the FOA, prospective applicants should contact Scientific/Research contact the relevant NIH ICO identified the end the FOA. General inquiries the FOA about extension Notice, be directed to: Ann Hardy Office Extramural Programs Telephone:  301-435-2690 Email: hardyan@od.nih.gov nbsp;

Notice National Institute Nursing Research NINR) Participation RFA-HG-14-001 BD2K-LINCS-Perturbation Data Coordination Integration Center DCIC) U54)" Notice Number: NOT-NR-14-003 Key Dates Release Date: December 6, 2013 Related Announcements RFA-HG-14-001 Issued National Institute Nursing Research NINR) Purpose purpose this Notice to inform potential applicants the National Institute Nursing Research NINR) participating RFA-HG-14-001 quot;BD2K-LINCS-Perturbation Data Coordination Integration Center DCIC) U54).” following sections of RFA-HG-14-001 have updated reflect participation NINR this FOA. Part 1. Overview Information Components Participating Organizations National Cancer Institute NCI) National Eye Institute NEI) National Heart, Lung, Blood Institute NHLBI) National Human Genome Research Institute NHGRI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Allergy Infectious Diseases NIAID) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Dental Craniofacial Research NIDCR) National Institute Diabetes Digestive Kidney Diseases NIDDK) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) National Library Medicine NLM) National Institute Minority Health Health Disparities NIMHD) National Center Complementary Alternative Medicine NCCAM) Office Strategic Coordination Common Fund) Catalog Federal Domestic Assistance CFDA) Number(s) 93.172; 93.121; 93.846; 93.213; 93.839; 93.838; 93.837; 93.233; 93.866; 93.847; 93.307; 93.399; 93.396; 93.395; 93.394; 93.393; 93.310; 93.173; 93.867; 93.113; 93.856; 93.855; 93.242; 93.273; 93.853; 93.879; 93.279; 93.286; 93.361 Inquiries Please direct inquiries to: Lyn Hardy, PhD, RN National Institute Nursing Research NINR) Telephone: 301) 594-5976 Email: hardylr@mail.nih.gov nbsp;