The purpose of this time-sensitive Request for Information (RFI) is to seek input from people living with amyotrophic lateral sclerosis (ALS), families, caregivers, advocates, scientists, clinicians, and the broader community on the most important knowledge gaps and promising research opportunities that will lead to the discovery of effective interventions for the diagnosis, treatment, management, prevention, or cure of ALS.

The goal of this funding opportunity announcement is to support a Human Pain-associated Genes & Cells Data Coordination and Integration Center as part of the NIH HEAL Initiatives Program to Reveal and Evaluate Cells-to-gene Information that Specify Intricacies, Origins and the Nature of Human Pain (PRECISION Human Pain). The Data Coordination and Integration Center will extract, accumulate, organize, annotate, and link growing bodies of information related to core datasets generated by companion U19 Centers for Discovery and Functional Evaluation of Human Pain-associated Genes & Cells, which include the characterization of functional genetic elements, epigenetic signatures, and molecular/cellular pathways that underlie human pain signal transduction, transmission and processing. The Human Pain-associated Genes & Cells Data Coordination and Integration Center will lead efforts to establish spatial and semantic standards for managing heterogeneous human pain-associated data types and information, collect and register multimodal human pain-associated data to common neural tissue coordinate systems, and establish a web-accessible information system that can be widely used throughout the research community. A central goal of the PRECISION Human Pain network is to act as a data repository and generate a comprehensive, integrated datasets on human genes and cellular function phenotypes underlying the heterogeneity, pathogenesis and susceptibility to specific pain conditions.

This Notice of Special Interest (NOSI) is issued by the National Institute of Neurological Disorders and Stroke (NINDS) to outline NINDS priorities for applications in the field of headache and migraine research in Fiscal Year 2022. Recognizing the urgent need to increase the study of neurological conditions associated with pain such as headache and migraine, the Fiscal Year 2022 draft budgets from the President, House, and Senate each include proposals to increase funding for pain research within NINDS mission. With this NOSI, NINDS wishes to inform the science community of the headache and migraine research opportunities that will present themselves, if funds become available. To be considered for funding through this initiative in Fiscal Year 2022, applications will need to be submitted to corresponding due dates starting in January or February 2022 so they can undergo Scientific Merit and NINDS Advisory Council review for the September 2022 Council round. For funding consideration, applicants must include NOT-NS-22-051 (without quotation marks) in the Agency Routing Identifier field (box 4B) of the SF424 R&R form. Applications without this information in box 4B will not be considered for this initiative. Applications deemed nonresponsive to the terms of this notice will not be considered for this initiative.

The National Institute of Neurological Disorders and Stroke (NINDS) invites applications to expand existing NINDS awards that are not currently focused on pain researchto allow the research to develop such a focus. Active awards with project end dates in FY 2023 or later are eligible. The award may not be in a terminal no-cost extension or going into a no-cost extension in FY 2022. As administrative supplements, the work proposed needs to be within the scope of the research or training that is already supported. Awardees are expected to follow-up on the supplement and seek competing support to continue promising leads from the research supported through the supplement. Awards that currently focus on pain research are not eligible for this program. If an investigator is uncertain whether the parent project does carry a pain focus as defined by NIH, then the investigator may contact the appropriate program officer who can check that status. All grant awards made by NINDS are eligible with the exception of the following: F30, F31, F32, T32, T35, K99, R13, and U13. Eligibility criteria can be found within PA-20-272 The goal of the supplement should be to add a pain component to the parent project, where a significant pain component doesnt exist. For the administrative supplements, the following examples of the parent project research areas will be considered, note this list is not exhaustive, any grant in NINDS portfolio is eligible, excluding the mechanisms listed above.