Notice Support Administrative Supplements Embed Ethicists BRAIN Initiative Supported Research Notice Number: NOT-MH-18-034 Key Dates Release Date: 01, 2018 Related Announcements None Issued National Institute Mental Health NIMH) National Eye Institute NEI) National Institute Aging NIA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose Brain Research through Advancing Innovative Neurotechnologies BRAIN) Initiative aimed revolutionizing neuroscience through development application innovative technologies map neural circuits, monitor modulate activity, understand they contribute thoughts, sensations, emotions behavior. NIH issued variety Funding Opportunity Announcements FOAs) will support projects apply technologies understand neural circuit function the context specific circuits, resulting a diverse portfolio research the fundamental biology nervous system function.  purpose this announcement to notify research community NIH encouraging applications to PA-18-591 to integrate neuroethics perspectives approaches existing BRAIN Initiative awards. Supplement applications encouraged ongoing BRAIN Initiative projects can readily incorporate core ethical issues associated research focused the human brain resulting emerging technologies advancements research development supported the BRAIN Initiative. intent that efforts supported through administrative supplement be both complimentary integrative the transformative, breakthrough neuroscience discoveries supported through BRAIN Initiative.   an administrative supplement, work proposed needs be within scope the research is already supported. Research proposed supplement applications should clear relevance the BRAIN Initiative. proposed work cover pilot projects, resource development, personnel costs embedding neuroethics the research project. each case, work proposed should feasible complete within one-year timeframe with limited funds permitted. should also show promise becoming more substantial project might attract additional funding. Investigators should submit applications responses the parent active administrative supplement announcement https://grants.nih.gov/grants/guide/pa-files/PA-18-591.html) using electronic submission. Electronic applications strongly encouraged.. Individual requests be more 100,000 direct costs exclusive Facilities Administrative costs sub-contracts may for year only. Requests must received June 15 funding FY 2018. Inquiries Please direct inquiries to: James Churchill National Institute Mental Health NIMH) Telephone: 301-443-3621 Email: churchillj@mail.nih.gov 

Notice Availability Administrative Supplements Secondary Analysis Existing Datasets within Rare Diseases Clinical Research Network RDCRN) Explore Outcomes Relevant Rare Diseases Notice Number: NOT-TR-18-019 Key Dates Release Date: April 25, 2018 Related Announcements PA-18-591 Issued National Center Advancing Translational Sciences NCATS) National Heart, Lung, Blood Institute NHLBI) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Dental Craniofacial Research NIDCR) National Institute Diabetes Digestive Kidney Diseases NIDDK) National Institute Neurological Disorders Stroke NINDS) Purpose National Center Advancing Translational Science NCATS) announces opportunity investigators relevant active Rare Diseases Clinical Research Consortia RDCRC) Rare Diseases Clinical Research Network RDCRN) U54) submit administrative supplement requests the NIH Parent Funding Opportunity Announcement FOA), ldquo;Administrative Supplements Existing NIH Grants Cooperative Agreements Parent Admin Supp Clinical Trial Optional)” PA-18-591 .   is vitally important begin use existing RDCRC datasets they intended: through secondary analyses develop new hypotheses Rare Diseases outcomes; such identify particular vulnerabilities specific populations; explore age, sex racial differences may warrant larger studies; discover new treatment/rehabilitation approaches; reveal correlations among outcomes outcome domains can guide future studies.   goal to existing human datasets well-focused secondary analyses investigate novel scientific ideas new models, systems, tools, methods, technologies have potential significant impact biomedical biobehavioral research areas relevant the RDCRN’s mission. RDCRN's mission to foster development scientific knowledge needed enhance health, productivity, independence, quality-of-life individuals Rare Diseases. Program Director(s)/Principal Investigators PIs) strongly encouraged partner Early Stage Investigators ESIs).  Projects must propose collect new data must within scope the current award. Budget Available Funds Budgets limited no than 50K direct costs. Award Project Period Supplement project budget periods limited the remaining FY18 budget period.  be eligible, parent award must active i.e. be an extension period), the research proposed the supplement must accomplished within remaining active budget period started FY18 the existing parent award. earliest anticipated start date July 1, 2018. Review process Administrative Review be conducted a committee NIH RDCRN Program Officers/Program Directors final decisions by funding ICs Page Limit NCATS consider supplements a Research Strategy no than 3 pages. Submitting Application Applicants should begin application stating: ldquo;This application being submitted response NOT-TR-18-019".  additional information, the parent program announcement Administrative Supplements Existing NIH Grants Cooperative Agreements Parent Admin Supp Clinical Trial Optional) PA-18-591. Applications these administrative supplements due 5:00 PM local time June 8, 2018. Inquiries Please direct inquiries to: Tiina K. Urv, PhD National Center the Advancement Translational Science NCATS) Telephone: 301-827-2746 Email: urvtiina@nih.gov

RESCINDED - Notice Change NINDS K99/R00 Eligibility Timeframe Parents Have Child during Standard K99/R00 Application Eligibility Window Notice Number: NOT-NS-18-055 Key Dates Release Date: April 17, 2018 Related Announcements NOT-NS-18-042 - RESCINDED Issued National Institute Neurological Disorders Stroke NINDS) Purpose notice being issued inform recipients NIH rescinded NOT-NS-18-042 Notice Change NINDS K99/R00 Eligibility Timeframe Parents Have Child during Standard K99/R00 Application Eligibility Window" until further review the policy. Inquiries Please direct inquiries to: Stephen Korn, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-4188 Email: korns@ninds.nih.gov

Alzheimer's Disease its related Dementias AD/ADRD)-focused Administrative supplements NIH grants are focused Alzheimer's disease Notice Number: NOT-AG-18-008 Key Dates Release Date: April 12, 2018 Related Announcements NOT-AI-18-032 NOT-HD-18-010 PA-18-591 Issued National Institute Aging NIA) National Cancer Institute NCI) National Eye Institute NEI) National Heart, Lung, Blood Institute NHLBI) National Human Genome Research Institute NHGRI) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Allergy Infectious Diseases NIAID) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) National Institute Biomedical Imaging Bioengineering NIBIB) National Institute Dental Craniofacial Research NIDCR) National Institute Deafness Other Communication Disorders NIDCD) National Institute Diabetes Digestive Kidney Diseases NIDDK) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute General Medical Sciences NIGMS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) National Institute Minority Health Health Disparities NIMHD) National Library Medicine NLM) Fogarty International Center FIC) National Center Complementary Integrative Health NCCIH) Division Program Coordination, Planning Strategic Initiatives, Office Research Infrastructure Programs ORIP) Office Research Women’s Health ORWH) Office Strategic Coordination Common Fund) Purpose participating Institutes Centers ICs) inviting applications expand existing awards these ICs are currently focused Alzheimer’s disease AD) its related dementias ADRD) allow to develop focus AD/ADRD. Active awards project end dates FY 2019 later eligible. award not in terminal cost extension going no cost extension FY2018. administrative supplements work proposed needs be within scope the research training is already supported. Center awards resource awards most likely be able justify supplements they tend have broad content scope. research grants also qualify the current research on related topic such cognitive decline aging, caregiving, health disparities). possible topics include research the biology neurodegeneration, genetics, imaging, on pain perception communication. Topics also include possible connections existing conditions are being studied: such links cardiovascular other diseases, common pathways degeneration, sex gender influences incidence, on previously unidentified risk factors. Also work focuses advances methodology, machine learning other modeling, or on biostatistical tools have application research Alzheimer’s its related dementias be appropriate. NIA developed website shows abstracts Reporter) a sample awards are recognized pursuing AD/ADRD research under current guidelines. site also includes description the categories research NIH currently identifies Alzheimer's disease Alzheimer's disease-related dementias. part the application investigators should submit abstract the proposed research shows relevance AD/ADRD. work include pilot projects, resource development. Investigators should submit applications responses the parent active administrative supplement PA: https://grants.nih.gov/grants/guide/pa-files/PA-18-591.html Individual requests be more 250,000 direct costs exclusive Facilities Administrative costs sub-contracts except the information NHGRI below). Requests be one year support only.  Though supplement requests not limited one per parent grant, will consider substantial additional funding an award beyond scope. Also, before submitting supplement request, principal investigators strongly encouraged contact program officers the Institute, Center Office supporting award discuss whether proposed supplement within scope. Requests must received June 8 funding FY 2018. Institute, Center Office-specific Instructions National Human Genome Research Institute: NHGRI collaboration NIA support supplements NHGRI grants to 500,000 direct cost, support research accomplishes NIA’s research goals described this notice. NHGRI support studies provide generalizable methods knowledge all three scientific areas genome sciences, genomic medicine genomics society. Work proposed supplements must fall within scope the aims the NHGRI grant be supplemented. Investigators encouraged contact NHGRI Scientific Program Officer the grant be supplemented before preparing application, discuss relevance the proposed research the parent grant to Institute's research priorities. National Institute General Medical Sciences: NIGMS’s MIRA program provides support an investigator's overall program research within Institute’s mission, MIRA awardees not eligible this supplement program. Office Strategic Coordination:  Common fund awardees are interested applying should contact Dr. Ravi Basavappa the Office Strategic Coordination Common Fund) before applying. Review process IC conduct administrative reviews applications their IC separately. NIA make funds available up ten awards each the participating ICs is allocating to 20 million this cross-IC program. IC conduct administrative reviews applications their IC separately. NIA make funds available up ten awards each the participating ICs is allocating to 20 million this cross-IC program.   Criteria: 1.      the work proposed within scope the active award? 2.      the work proposed focused Alzheimer’s disease its related dementias? 3.      the work likely stimulate additional activity leading progress AD/ADRD? Inquiries Please direct inquiries to: Robin A. Barr National Institute Aging NIA) Telephone: 301-402-7715 E-mail: BarrR@mail.nih.gov Crystal Wolfrey National Cancer Institute NCI) Telephone: 240-276-6277 E-mail: wolfreyc@mail.nih.gov Martha Flanders National Eye Institute NEI) Telephone: 301-451-2020 E-mail: Martha.flanders@nih.gov Jue Chen, Ph.D. National Heart, Lung, Blood Institute NHLBI) Telephone: 301-435-0550 Email: jue.chen@nih.gov Bettie Graham National Human Genome Research Institute NHGRI) Telephone: 301-496-7531 E-mail: grahambj@exchange.nih.gov Abraham Bautista National Institute Alcohol Abuse Alcoholism NIAAA) Telephone: 301-443-9737 E-mail: Bautista@mail.nih.gov Michael Minnicozzi, Ph.D. National Institute Allergy Infectious Diseases NIAID) Telephone: 240-627-3532 Email: minnicozzim@niaid.nih.gov Melinda Nelson National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) Telephone: 301-435-5278 E-mail: nelsonm@exchange.nih.gov Randy King National Institute Biomedical Imaging Bioengineering NIBIB) Telephone:301-451-4780 E-mail: randy.king@nih.gov Judith Cooper National Institute Deafness Other Communication Disorders NIDCD) Telephone: 301-496-5061 E-mail: cooperj@nidcd.nih.gov Preethi Chander National Institute Dental Craniofacial Research NIDCR) Telephone: 301-827-4620 E-mail: Preethi.chander@nih.gov Luke Stoekel National Institute Diabetes Digestive Kidney Diseases NIDDK) Telephone: 301-741-9223 E-mail: luke.stoeckel@nih.gov Kevin Walton National Institute Drug Abuse NIDA) Telephone: 301-827-5980 kevin.walton@nih.gov Jonathan Hollander National Institute Environmental Health Sciences NIEHS) Telephone: 984-287-3269 E-mail: jonathan.hollander@nih.gov Janna Wehrle National Institute General Medical Sciences NIGMS) Telephone: 301451-6446 E-mail: wehrlej@nigms.nih.gov Jovier Evans National Institute Mental Health NIMH) Telephone: 301-443-1369 E-mail: jevans1@mail.nih.gov Roderick Corriveau National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-5680 E-mail: roderick.corriveau@nih.gov Lois Tully National Institute Nursing Research NINR) Telephone: 301-594-5968 E-mail: lois.tully@nih.gov Adelaida Rosario National Institute Minority Health Health Disparities NIMHD) Telephone: 301-402-1366 E-mail: Adelaida.rosario@nih.gov Hua-Chuan Sim National Library Medicine NLM) Telephone: 301-594-4882 E-mail: simh@mail.nlm.nih.gov Marya Levintova Fogarty International Center FIC) Telephone: 301-496-1653 E-mail: levintovam@mail.nih.gov Dave Clark National Center Complementary Integrative Health NCCIH) Telephone: 301-827-1916 E-mail: dave.clark@nih.gov Stephanie Murphy Division Program Coordination, Planning Strategic Initiatives, Office Research Infrastructure Programs ORIP) Telephone: 301-435-0744 E-mail: Stephanie.murphy@nih.gov Chyren Hunter Office Research Women’s Health ORWH) Telephone: 301-402-1770 Email: hunterc@mail.nih.gov Ravi Basavappa Office Strategic Coordination OSC) Telephone: 301-435-7204 E-mail: ravikumar.basavappa@nih.gov