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Notice of Special Interest (NOSI): Sleep Disorders and Circadian Clock Disruption in Alzheimers Disease and other Dementias of Aging

Notice of Special Interest
Monday, January 10, 2022
Wednesday, November 13, 2024
R01
NOT-AG-21-051

Funding Opportunity Purpose

The aim of this Notice of Special Interest (NOSI)is to advance basic and clinical research on the causes and consequences of sleep deficiency and circadian clock dysfunction in Alzheimer's disease (AD) and Alzheimers disease-related dementias (ADRD), and the roles of sleep and the circadian clock as modifiers of the onset and progression of neurodegeneration.

Notice of Special Interest (NOSI): BRAIN Initiative: Translation of Groundbreaking Technologies from Early-stage Development through Early Clinical Study via Blueprint MedTech

Notice of Special Interest
Wednesday, January 5, 2022
Friday, June 21, 2024
NOT-NS-22-052

Funding Opportunity Purpose

This Notice of Special Interest (NOSI) encourages the translation of the novel neurotechnologies, funded through the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative and overseen by the NIH Blueprint MedTech program. Academic and Small Business Concerns (SBCs) are encouraged to submit grant applications that propose non-clinical validation for subsequent clinical feasibility studies. Applications supporting the development and translation of groundbreaking neurotechnologies that fit within the mission of the BRAIN Initiative are encouraged.

Request for Information: Soliciting Input on Research Priorities for Amyotrophic Lateral Sclerosis (ALS)

NOT
Tuesday, January 4, 2022
Wednesday, January 1, 2025
NOT-NS-22-056

Funding Opportunity Purpose

The purpose of this time-sensitive Request for Information (RFI) is to seek input from people living with amyotrophic lateral sclerosis (ALS), families, caregivers, advocates, scientists, clinicians, and the broader community on the most important knowledge gaps and promising research opportunities that will lead to the discovery of effective interventions for the diagnosis, treatment, management, prevention, or cure of ALS.

Notice of Intent to Publish a Funding Opportunity Announcement for HEAL Initiative: Discovery and Functional Evaluation of Human Pain-associated Genes & Cells (U19 Clinical Trial Not Allowed)

NOT
Tuesday, December 28, 2021
Wednesday, January 1, 2025
NOT-NS-22-065

Funding Opportunity Purpose

The purpose of this funding opportunity announcement is to support research that uses human tissue or cells to generate comprehensive datasets for the discovery and characterization of functional genetic elements, epigenetic signatures, and molecular/cellular pathways that underlie human pain transduction, transmission, and processing. This FOA will support concerted multidisciplinary team science efforts that apply large-scale high-throughput approaches on tissues involved in human pain processing as part of the NIH HEAL Initiatives Program to Reveal and Evaluate Cells-to-gene Information that Specify Intricacies, Origins, and the Nature of Human Pain (PRECISION Human Pain). U19 Centers will operate as a cooperative network to promote collaboration and coordination of research activities. U19 Centers will also coordinate with the U24 HEAL Initiative: Human Pain-associated Genes & Cells Data Coordination and Integration Center in order to extract, accumulate, organize, annotate, and link the datasets generated by this U19 research program.

Notice of Intent to Publish a Funding Opportunity Announcement for HEAL Initiative: Human Pain-associated Genes & Cells Data Coordination and Integration Center (U24 Clinical Trial Not Allowed)

NOT
Tuesday, December 28, 2021
Wednesday, January 1, 2025
NOT-NS-22-063

Funding Opportunity Purpose

The goal of this funding opportunity announcement is to support a Human Pain-associated Genes & Cells Data Coordination and Integration Center as part of the NIH HEAL Initiatives Program to Reveal and Evaluate Cells-to-gene Information that Specify Intricacies, Origins and the Nature of Human Pain (PRECISION Human Pain). The Data Coordination and Integration Center will extract, accumulate, organize, annotate, and link growing bodies of information related to core datasets generated by companion U19 Centers for Discovery and Functional Evaluation of Human Pain-associated Genes & Cells, which include the characterization of functional genetic elements, epigenetic signatures, and molecular/cellular pathways that underlie human pain signal transduction, transmission and processing. The Human Pain-associated Genes & Cells Data Coordination and Integration Center will lead efforts to establish spatial and semantic standards for managing heterogeneous human pain-associated data types and information, collect and register multimodal human pain-associated data to common neural tissue coordinate systems, and establish a web-accessible information system that can be widely used throughout the research community. A central goal of the PRECISION Human Pain network is to act as a data repository and generate a comprehensive, integrated datasets on human genes and cellular function phenotypes underlying the heterogeneity, pathogenesis and susceptibility to specific pain conditions.

Notice of Information: Multi-Institute Interest in Pain Research

NOT
Monday, December 27, 2021
Heal
Wednesday, January 1, 2025
NOT-NS-22-057

Funding Opportunity Purpose

The purpose of this notice is to inform potential applicants to the National Institute on Aging (NIA); National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); National Center for Complementary and Integrative Health (NCCIH); National Institute of Dental and Craniofacial Research (NIDCR); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); and the National Institute of Neurological Disorders and Stroke (NINDS) of areas of pain research that are of special interest to these Institutes. The Institutes are interested in receiving applications for potential funding in FY22 that seek to provide new knowledge of the mechanistic complexity of pain that may lead to more effective, non-addictive treatments for pain conditions related to the missions of these Institutes. This Notice is also intended to inform investigators of the special research opportunities available through the multi-Institute and Center Helping to End Addiction Long-term (HEAL) Initiative.

Notice of Special Interest (NOSI) in Migraine and Headache Research

Notice of Special Interest
Monday, December 27, 2021
Sunday, May 8, 2022
NOT-NS-22-051

Funding Opportunity Purpose

This Notice of Special Interest (NOSI) is issued by the National Institute of Neurological Disorders and Stroke (NINDS) to outline NINDS priorities for applications in the field of headache and migraine research in Fiscal Year 2022. Recognizing the urgent need to increase the study of neurological conditions associated with pain such as headache and migraine, the Fiscal Year 2022 draft budgets from the President, House, and Senate each include proposals to increase funding for pain research within NINDS mission. With this NOSI, NINDS wishes to inform the science community of the headache and migraine research opportunities that will present themselves, if funds become available. To be considered for funding through this initiative in Fiscal Year 2022, applications will need to be submitted to corresponding due dates starting in January or February 2022 so they can undergo Scientific Merit and NINDS Advisory Council review for the September 2022 Council round. For funding consideration, applicants must include NOT-NS-22-051 (without quotation marks) in the Agency Routing Identifier field (box 4B) of the SF424 R&R form. Applications without this information in box 4B will not be considered for this initiative. Applications deemed nonresponsive to the terms of this notice will not be considered for this initiative.

Notice of Special Interest (NOSI) in NINDS mission relevant Pain Research

Notice of Special Interest
Monday, December 27, 2021
Heal, Neural Exposome
Sunday, May 8, 2022
NOT-NS-22-050

Funding Opportunity Purpose

The purpose of this Notice of Special Interest (NOSI) is to outline NINDS priorities for applications in the field of pain research in Fiscal Year 2022. Recognizing the urgent need to understand the basic science aspect of pathological pain to improve its management, Fiscal Year 2022 draft budgets from the President, House, and Senate each include proposals to increase funding for pain research within NINDS mission. With this NOSI, NINDS wishes to inform the science community of the pain research opportunities that will present themselves, if funds become available. To be considered for funding through this initiative in Fiscal Year 2022, applications will need to be submitted to corresponding due dates starting in January or February 2022 so they can undergo Scientific Merit and NINDS Advisory Council review for the September 2022 Council round. For funding consideration, applicants must include NOT-NS-22-050 (without quotation marks) in the Agency Routing Identifier field (box 4B) of the SF424 R&R form. Applications without this information in box 4B will not be considered for this initiative. Applications deemed nonresponsive to the terms of this notice will not be considered for this initiative.

Notice of Special Interest (NOSI): Pain-Focused Administrative Supplements for NINDS Grants that are Not Focused on Pain Research

Notice of Special Interest
Thursday, December 23, 2021
Thursday, June 2, 2022
333
NOT-NS-22-053

Funding Opportunity Purpose

The National Institute of Neurological Disorders and Stroke (NINDS) invites applications to expand existing NINDS awards that are not currently focused on pain researchto allow the research to develop such a focus. Active awards with project end dates in FY 2023 or later are eligible. The award may not be in a terminal no-cost extension or going into a no-cost extension in FY 2022. As administrative supplements, the work proposed needs to be within the scope of the research or training that is already supported. Awardees are expected to follow-up on the supplement and seek competing support to continue promising leads from the research supported through the supplement. Awards that currently focus on pain research are not eligible for this program. If an investigator is uncertain whether the parent project does carry a pain focus as defined by NIH, then the investigator may contact the appropriate program officer who can check that status. All grant awards made by NINDS are eligible with the exception of the following: F30, F31, F32, T32, T35, K99, R13, and U13. Eligibility criteria can be found within PA-20-272 The goal of the supplement should be to add a pain component to the parent project, where a significant pain component doesnt exist. For the administrative supplements, the following examples of the parent project research areas will be considered, note this list is not exhaustive, any grant in NINDS portfolio is eligible, excluding the mechanisms listed above.

Notice of Intent to Publish a Funding Opportunity Announcement for HEAL Initiative: Restoring Joint Health and Function to Reduce Pain Consortium (RE-JOIN) (UC2 Clinical Trial Not Allowed)

NOT
Monday, December 20, 2021
Wednesday, January 1, 2025
NOT-AR-22-015

Funding Opportunity Purpose

HEAL Initiative: Restoring Joint Health and Function to Reduce Pain Consortium (RE-JOIN) (UC2 Clinical Trial Not Allowed) - The purpose of this Funding Opportunity Announcement is to solicit cooperative agreement applications to support interdisciplinary teams that will work together to form the Restoring Joint Health and Function to Reduce Pain Consortium (RE-JOIN). The goal of RE-JOIN will be to define the innervation of the different tissues, which collectively form the joints, by sensory neurons that mediate the sensation of pain. Knowledge about the types and distribution of neurites in joint tissues will facilitate the identification of key receptors and mediators that induce pain by activating specific sensory neurons. These mediators or their receptors will provide novel targets for reducing pain.

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