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The purpose of this FOA is to solicit applications for a coordination center that will narrow the gap between the availability of biomedical big data and the ability of biomedical scientists to effectively utilize such data accurately, effectively, and efficiently. Achieving this goal requires: (1) bringing together individuals involved in training and career development programs to network and share experiences; and (2) engaging individuals developing open educational resources in meaningful dialogue to ensure that the resources they develop will be freely available and easy to access by the broader biomedical community. By the end of the award period, the Training Coordination Center (TCC) will be expected to have: (1) developed a network of scientists involved in biomedical big data science and (2) produced a discovery index that serves as a primary source for personalized access to publicly available biomedical data science educational resources.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nations biomedical, behavioral and clinical research needs. To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on Courses for Skills Development that will build participants foundational knowledge and skills in the rigorous use of state-of-the art scientific tools and methods that contribute to, and are developed in response to, the major goals of the BRAIN Initiative. Each short course is expected to include both didactics and in-person / hands-on experiences. This FOA is intended for participants who are graduate students, medical students, postdoctoral scholars, medical residents, and/or early-career faculty.

The purpose of this Funding Opportunity Announcement (FOA) is to encourage Research Project Grant (R01) applications to explore two timely issues of significance for policy development relevant to: 1) the principles and characteristics for central Institutional Review Boards (IRBs); and 2) consent and participant preferences for research using clinical records and data.

This FOA provides funding to conduct pharmacodynamics, pharmacokinetics, and in vivo efficacy studies to demonstrate that proposed therapeutic agent(s) have sufficient biological activity to warrant further development to treat neurological disorders. Therapeutic agents may include but are not limited to small molecules, biologics or biotechnology-derived products. This FOA is part of a suite of Innovation Grants to Nurture Initial Translational Efforts (IGNITE) to advance projects to the point where they can meet the entry criteria for NINDS Cooperative Research to Enable and Advance Translational Enterprises program (CREATE) for biologics, biotechnology products, the Blueprint Neurotherapeutics Network (BPN) for small molecules, or other translational program.

This Funding Opportunity Announcement (FOA) invites applications for the Morris K. Udall Centers of Excellence for Parkinsons Disease Research program. The overarching goal of the specialized Udall Centers program is to establish a network of Centers that work collaboratively as well as independently to define the causes of and discover improved treatments for Parkinsons disease (PD). A more immediate goal for each Center is to rapidly advance synergistic, interdisciplinary research programs while serving as local resources and national leaders in PD research. The overall theme, proposed research projects, and associated cores must inform the etiology, pathogenesis or treatment of PD. Investigations on related synucleinopathies may be included, to the extent that these directly inform PD research. Requirements include 1) a minimum of three research projects; 2) research cores that are each essential to accomplish the aims of at least two proposed research projects, plus an Administrative Core; 3) a mission statement and plan for career development of PD researchers; and 4) a plan for outreach to the local patient community. The NINDS Udall Centers program prioritizes innovative and integrative research with significant potential for discovery. A considerable degree of synergy must be evident among Center research projects and cores, such that successful completion of the aims could not be accomplished without the Center structure. The Udall Center Director (PD/PI) must be an established leader in scientific research with visionary leadership skills and proven expertise in the stewardship of large-scale research programs. Eligible institutions must demonstrate commitment to and support for the establishment and continuation of the proposed Udall Center. Funding decisions will focus on those applications most likely to make highly impactful contributions to PD research, as well as those with greatest potential to collaborate effectively across the Centers program.

This funding opportunity announcement (FOA) encourages research grant applications to develop in vitro and/or ex vivo assays and conduct iterative screening efforts to identify and characterize potential therapeutic agents for neurological disorders. This FOA is part of a suite of Innovation Grants to Nurture Initial Translational Efforts (IGNITE) to advance projects to the point where they can meet the entry criteria for NINDS Cooperative Research to Enable and Advance Translational Enterprises program (CREATE) for biologics, biotechnology products, the Blueprint Neurotherapeutics Network (BPN) for small molecules, or other translational program.

This Funding Opportunity Announcement (FOA) invites applications for a Research Coordinating Unit. This unit will facilitate the coordination among and between the awardees of RFA-HL-15-021, "Testing Multi-Level Interventions to Improve Blood Pressure Control in Minority Racial/Ethnic, Low Socioeconomic Status, and/or Rural Populations (UH2/UH3)". This initiative is supported by the Hypertension Disparities Reduction Program Partnership (HDRPP), a research partnership between NHLBI, NINDS, and the Patient-Centered Outcomes Research Institute (PCORI), with funds provided by PCORI to the NIH.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this BD2K R25 FOA is to complement and/or enhance the training of a workforce to meet the nations biomedical, behavioral and clinical research needs. To accomplish the stated over-arching goal, this FOA will focus on Curriculum or Methods Development. In particular, this FOA seeks applications for development of an open, online educational resource.

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this BD2K R25 funding announcement is to complement and/or enhance the training of a workforce to meet the nations biomedical, behavioral and clinical research needs. To accomplish the stated over-arching goal, this FOA will focus on Curriculum or Methods Development. In particular, this FOA seeks applications for development of open educational resources.

The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function. The new tools and technologies should inform and/or exploit cell-type and/or circuit-level specificity. Plans for validating the utility of the tool/technology will be an essential feature of a successful application. The development of new genetic and non-genetic tools for delivering genes, proteins and chemicals to cells of interest or approaches that are expected to target specific cell types and/or circuits in the nervous system with greater precision and sensitivity than currently established methods are encouraged. Tools that can be used in a number of species / model organisms rather than those restricted to a single species are highly desired. Applications that provide approaches that break through existing technical barriers to substantially improve current capabilities are highly encouraged.