David H. Gutmann, M.D.,Ph.D.

Research Program Award (R35)
Photo of David Gutmann, M.D., Ph.D. FY17 Research Program Award (R35) recipient
Institution
Washington University, St. Louis, MO
Awarded Project
Defining the mechanistic basis for Neurofibromatosis-1 nervous system disease heterogeneity

Neurofibromatosis type 1 (NF1) is a rare genetic condition leading to cognitive and behavioral problems, low-grade brain tumors, and other symptoms that vary across affected individuals. Currently, there is no way to predict disease course or severity in an individual child with NF1. To address this challenge and inform precision-medicine strategies, Dr. Gutmann will study disease variability using patient-derived cells, genetic mouse models, and bioinformatics approaches.