Subjects are recruited as patients in one of the neurology, neurosurgery or neuro-oncology clinics at OHSU. There are four groups of the study: - Subjects receive the combidex infusion only. - Subjects receive Combidex and undergo a previously schedule neurosurgery. - Subjects undergo surgery only and provide a sample of their tumor tissue to be used in pathology studies of Combidex. - Subjects with MS or stroke are invited to participate in receiving Combidex to evaluate the effectiveness of enhancing the area of damage within the brain. Subjects are deemed eligible for the study and undergo a baseline MRI within 28 days of receiving Combidex. Subjects receiving Combidex are admitted for a half day into the Oregon Clinical & Translational Research Institute(OCTRI). Combidex is infused I.V. over 30 minutes. Subjects are monitored for side effects and are discharged within about 5 hours after the infusion, if no complications have been noted. Subjects return 24 hours after the infusion for a post infusion MRI scan and return again to one of the neurology clinics for one month follow-up. Subjects enrolled in group 2 undergo surgery 1-2 days after the Combidex infusion and also undergo a 24 post infusion MRI and return for one month follow-up. These subjects are also followed closely by the neurosurgical physician during the course of follow-up. Subjects enrolled in group 3 only undergo surgery and agree to have a piece of their tumor resection or biopsy donated for use in the study. Group 4 is the same as group 1, except the patient population includes multiple sclerosis and stroke instead of patients with brain tumors.
Inclusion Criteria: - Brain tumor or CNS inflammatory lesion including stroke or MS - 5 yrs old or older - Able to undergo MRI without general anesthesia - Agree to be followed for 1 month following infusion of Combidex - Sign a written informed consent - If female and of child-bearing potential, be postmenopausal, sterile, or be on birth control for 1 month prior to study - Must have a pre-treatment MRI within 28 days before study Exclusion Criteria: - Clinically significant signs of uncal herniation - Allergy to study drug, Combidex - Hepatic insufficiency - Stage IV or V renal insufficiency - If female, pregnant or lactating - Require anesthesia for MRI scanning - Hemachromatosis