The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, is looking for individuals to participate in clinical studies. Participating in clinical trials allows you to play an active role in research on the nature and causes of many disorders of the brain and nervous system, and to possibly help physician-scientists develop future treatments. The information below is designed to help you quickly learn about actively recruiting research studies for which you or someone you know may be eligible.


This research study (03-N-0164) will evaluate people with a variety of neurosurgical disorders in order to provide standard expert care and physician training. In the study, doctors will assess and treat people who have disorders of the brain, spinal cord, peripheral nerves, or pituitary gland that may or may not require surgery. This study will not test new treatments. Participants will receive standard care.

The purposes of the study are to help researchers learn more about disorders that affect the nervous system, train physicians to evaluate and treat these disorders, and develop a pool of people who may be eligible for other NINDS studies. However, participants will not be required to join another study.

Approximately 2500 people will enroll in this study and be screened with a review of their medical history and a physical examination. Eligible participants may undergo tests and medical or surgical treatment to help diagnose and treat their condition. Procedures may include laboratory tests, imaging tests such as magnetic resonance imaging (MRI), computed tomography (CT), angiograms, and other procedures to confirm diagnosis or help guide treatment. Participants who require surgery will be offered standard surgical care at the National Institutes of Health (NIH) Clinical Center. Any leftover tissue and blood samples taken during standard treatment may be used for research. Participants and their blood relatives may undergo genetic testing if a genetic issue underlying the neurological disorder is suspected.

This is an observational study for training. There is no cost for participation in this study. Knowledge gained from this study may lead to future advances in the treatment of neurological disorders.

Eligibility Criteria:


  1. Age 4 and older.
  2. Neurosurgical-related conditions such as brain tumors, pituitary tumors, peripheral nerve tumors, epilepsy, Parkinson s disease, other abnormal movement disorders, Chiari I malformation, syringomyelia, and pain disorders, based on Surgical Neurology Branch training and teaching needs.
  3. For adults: able to provide informed consent or having a legally-authorized representative to provide consent, if incapacitated.
  4. For minors: a parent or legal guardian who is able to provide consent.
  5. For immediate blood relatives of subjects having genetic testing only:  Blood relative of a subject who is suspected to have a genetic mechanism underlying their neurological disorder (for genetic testing only)


  1. Medically unstable or severe organ failure based on clinical evaluation.

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