The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, is looking for individuals to participate in clinical studies. Participating in clinical trials allows you to play an active role in research on the nature and causes of many disorders of the brain and nervous system, and to possibly help physician-scientists develop future treatments. The information below is designed to help you quickly learn about actively recruiting research studies for which you or someone you know may be eligible.

Description:

This protocol will use functional magnetic resonance imaging (fMRI) to examine the localization of verbal working memory and translation systems in normal volunteers who speak English as a second language. Several important issues in areas such as language acquisition, cortical plasticity, and bilingualism will be advanced by an increased understanding of how multiple languages are represented in the brain. There are also an increasing number of bilingual patients who need to undergo surgical intervention, particularly for uncontrolled epilepsy, or suffer from a variety of neurological disorders affecting different languages to varying degrees. It is very important to accurately assess and localize language functions in these patients. This study will identify cortical areas activated by the immediate translation of words and sentences between native and second languages, as well as differences in verbal working memory systems between two languages. It will also evaluate differences in verbal working memory and translation systems among subjects with different proficiency and different age at acquisition of their second language. This study will advance our understanding of the cortical representation that underlies multiple language functions.

Eligibility Criteria:

LESS-FLUENT BILINGUALS: Native Korean speakers who have lived in the United States for at least one, but less than two years and have studied English after the age of 12. TOEFL (Test of English as a Foreign Language) score above 550. FLUENT BILINGUALS WITH EARLY ACQUISITION: Native Korean speakers who have been exposed to English before the age of 7 and have lived in the US after that. FLUENT BILINGUALS WITH LATE ACQUISITION: Native Korean speakers who have been exposed to English after the age of 12 and have lived in the US after that. ALL SUBJECTS: Ages 18-50 years old. No history of head injury. No history of neurological and thought disorder. Must not take any medication with cognitive side effects. Must not have any contraindication for fMRI (e.g. pacemaker, metallic surgical implantation, etc.). No left-handed persons. No persons who are unable to read the visually presented material.

Study Design:

Study Location:

No documented Location