The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, is looking for individuals to participate in clinical studies. Participating in clinical trials allows you to play an active role in research on the nature and causes of many disorders of the brain and nervous system, and to possibly help physician-scientists develop future treatments. The information below is designed to help you quickly learn about actively recruiting research studies for which you or someone you know may be eligible.

Description:

Blood samples will be drawn on traumatic brain injury patients who are participating in the ProTECT III study just prior to the initiation of the study drug infusion and 24 and 48 hours from the time they are enrolled in the study to test for biomarkers that may help predict how severe the injury is and how well they improve. The investigators will also test to see if the study medication is being absorbed and is staying at a consistent level in the blood stream.

Eligibility Criteria:

Inclusion Criteria: - Moderate to severe brain injury (iGCS 12-4 or motor response 2-5 if intubated). - Age >18 years (or developmental stage Tanner 5 in patients where age is not known) - Blunt, traumatic, closed head injury (altered mental status due to brain injury) - Able to initiate study drug infusion within 4 hours from time of injury - Exclusion Criteria: - Non-survivable injury as determined by treating - Bilateral dilated unresponsive pupils - Spinal cord injury with neurological deficits, pre-injury paralysis (quad/paraplegic) - Inability to perform activities of daily living (ADL) without assistance - Cardiopulmonary arrest - Status epilepticus on arrival or concern for post ictal state - systolic blood pressure

Study Design:

Study Location:

Multiple U.S. Locations