ALA-induced PpIX Fluorescence During Brain Tumor Resection

Inclusion Criteria: - Preoperative diagnosis of either presumed first-time low or high grade glioma, or recurrent glioma, or metastasis, or meningioma - Tumor judged to be suitable for open cranial resection based on preoperative imaging studies. - Patient or LAR able to provide written informed consent. - No serious associated psychiatric illnesses. - Age > 21 years old. Exclusion Criteria: - Pregnant women or women who are breast feeding - History of cutaneous photosensitivity, porphyria, hypersensitivity to porphyrins, photodermatosis, exfoliative dermatitis. - History of liver disease within the last 12 months. - Elevated liver function levels greater than 2.5 times the normal limit from laboratory tests conducted within 30 days prior to surgery. - Inability to comply with the photosensitivity precautions associated with the study. - Plasma creatinine in excess of 180umol/L within 30 days prior to surgery