The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, is looking for individuals to participate in clinical studies. Participating in clinical trials allows you to play an active role in research on the nature and causes of many disorders of the brain and nervous system, and to possibly help physician-scientists develop future treatments. The information below is designed to help you quickly learn about actively recruiting research studies for which you or someone you know may be eligible.


The ADAPT study will evaluate the effectiveness of different medical therapies on children with severe traumatic brain injury (TBI).

Each year TBI contributes to a substantial number of deaths and cases of permanent disability.   In fact, TBI is a contributing factor to a third of all injury-related deaths in the United States. 

This international study will enroll a total of 1000 children, age 0-17 years old, at 48 clinical sites.  The sites are in 8 different countries including the United States, the United Kingdom, the Netherlands, Spain, South Africa, India, Australia, and New Zealand.  The medical therapies to be evaluated in this study are considered routine care for children with severe TBI and will be provided by the participating hospitals.   Study researchers will collect information regarding these therapies from medical records and record the data in a confidential database.   Participants’ recovery will be assessed at 3, 6, and 12 months after injury.   Assessment tests will measure the child’s behavior, attention, and general thinking.

Duration of the study for participants is about 1 year. Information gained from this study may lead to a better understanding of the various approaches to managing the care of children with TBI.

Eligibility Criteria:

Eligible participants must be age 0-17 years old and have a severe TBI.

Study Design:


Study Location:

United States

Study Website: