CounterACT Publications 2016

CounterACT Publications 2016


Countermeasures against chemical threats banner

2018 | 2016 | 2015

CounterACT Publications 2016

Neurotoxic Agents

Appu AP, Arun P, Krishnan JK, Moffett JR, Namboodiri AM. (2016) Rapid intranasal delivery of chloramphenicol acetyltransferase in the active form to different brain regions as a model for enzyme therapy in the CNS. J Neurosci Methods. 259: 129-34.  Abstract

Aroniadou-Anderjaska V, Figueiredo TH, Apland JP, Prager EM, Pidoplichko VI, Miller SL, Braga MF. (2016) Long-term neuropathological and behavioral impairments after exposure to nerve agents. Ann N Y Acad Sci. [Epub ahead of print]  Abstract

Bourne Y, Sharpless KB, Taylor P, Marchot P. (2016) Steric and dynamic parameters influencing in situ cycloadditions to form triazole inhibitors with crystalline acetylcholinesterase. J Am Chem Soc. [Epub ahead of print]  Abstract

Carver C, Reddy DS. (2016) Neurosteroid Structure-Activity Relationships for Functional Activation of Extrasynaptic delta-GABA-A Receptors. J Pharmacol Exp Ther. [Epub ahead of print]  Abstract

Chambers JE, Meek EC, Chambers HW. (2016) Novel brain-penetrating oximes for reactivation of cholinesterase inhibited by sarin and VX surrogates. Ann N Y Acad Sci. [Epub ahead of print]  Abstract

Coban A, Carr RL, Chambers HW, Willeford KO, Chambers JE. (2016) Comparison of Inhibition Kinetics of Several Organophosphates, including Some Nerve Agent Surrogates, using Human Erythrocyte and Rat and Mouse Brain Acetylcholinesterase. Toxicol Lett. [Epub ahead of print]  Abstract

Koenig JA, Dao TL, Kan RK, Shih TM. (2016) Zebrafish as a model for acetylcholinesterase-inhibiting organophosphorus agent exposure and oxime reactivation. Ann N Y Acad Sci. [Epub ahead of print]  Abstract

Krishnan JK, Arun P, Appu AP, Vijayakumar N, Figueiredo TH, Braga MF, Baskota S, Olsen CH, Farkas N, Dagata J, Frey WH 2nd, Moffett JR, Namboodiri AM. (2016) Intranasal delivery of obidoxime to the brain prevents mortality and CNS damage from organophosphate poisoning. Neurotoxicology. 53:64-73.  Abstract

Rogawski MA, Löscher W, Rho JM. (2016) Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet. Cold Spring Harb Perspect Med. [Epub ahead of print]  Abstract

Wright LK, Lee RB, Vincelli NM, Whalley CE, Lumley LA. (2016) Comparison of the lethal effects of chemical warfare nerve agents across multiple ages. Toxicol Lett. 241:167-74.  Abstract


Vesicating Agents

Das LM, Binko AM, Traylor ZP, Duesler LR, Dynda SM, Debanne S, Lu KQ. (2016) Early indicators of survival following exposure to mustard gas: protective role of 25(OH)D. Toxicol Lett. [Epub ahead of print]  Abstract

DeSantis-Rodrigues A, Chang YC, A Hahn R, P Po I, Zhou P, Lacey CJ, Pillai A, C Young S, A Flowers Ii R, A Gallo M, D Laskin J, R Gerecke D, K H Svoboda K, D Heindel N, Gordon MK. (2016) ADAM17 Inhibitors Attenuate Corneal Epithelial Detachment Induced by Mustard Exposure. Invest Ophthalmol Vis Sci. 57(4):1687-98.  Abstract

Tewari-Singh N, Croutch CR, Tuttle R, Goswami DG, Kant R, Peters E, Culley T, Ammar DA, Enzenauer RW, Petrash JM, Casillas RP, Agarwal R. (2016) Clinical progression of ocular injury following arsenical vesicant lewisite exposure. Cutan Ocul Toxicol. [Epub ahead of print]  Abstract

Wohlman IM, Composto GM, Heck DE, Heindel ND, Lacey CJ, Guillon CD, Casillas RP, Croutch CR, Gerecke DR, Laskin DL, Joseph LB, Laskin JD. (2016) Mustard vesicants alter expression of the endocannabinoid system in mouse skin. Toxicol Appl Pharmacol. [Epub ahead of print]  Abstract


Pulmonary Agents

Conklin DJ. (2016) Acute cardiopulmonary toxicity of inhaled aldehydes: role of TRPA1. Ann N Y Acad Sci. [Epub ahead of print]  Abstract

Hoyle GW, Chen J, Schlueter CF, Mo Y, Humphrey DM Jr, Rawson G, Niño JA, Carson KH. (2016) Development and assessment of countermeasure formulations for treatment of lung injury induced by chlorine inhalation. Toxicol Appl Pharmacol. [Epub ahead of print]  Abstract

Jiang J, Chan A, Ali S, Saha A, Haushalter KJ, Lam WM, Glasheen M, Parker J, Brenner M, Mahon SB, Patel HH, Ambasudhan R, Lipton SA, Pilz RB, Boss GR. (2016) Hydrogen Sulfide-Mechanisms of Toxicity and Development of an Antidote. Sci Rep. [Epub ahead of print]  Abstract

Parseghian MH, Hobson ST, Richieri RA. (2016) Targeted heat shock protein 72 for pulmonary cytoprotection. Ann N Y Acad Sci. [Epub ahead of print]  Abstract

Perkins MW, Wong B, Tressler J, Coggins A, Rodriguez A, Devorak J, Sciuto AM. (2016) Assessment of inhaled acute ammonia-induced lung injury in rats. Inhalation Toxicology. [Epub ahead of print]  Abstract  


Metabolic/Cellular Poisons

Bartling CM, Andre JC, Howland CA, Hester ME, Cafmeyer JT, Kerr A, Petrel T, Petrikovics I, Rockwood GA. (2016) Stability Characterization of a Polysorbate 80-Dimethyl Trisulfide Formulation, a Cyanide Antidote Candidate. Drugs R D. [Epub ahead of print]  Abstract

Benz OS, Yuan Q, Cronican A, Peterson J, Pearce LL. (2016) The Effect of Ascorbate on the Cyanide Scavenging Capability of cobalt(III) meso-tetra(4-N-methylpyridyl)porphine triiodide: Deactivation by Reduction? Chem Res Toxicol. [Epub ahead of print]  Abstract

Greenawald LA, Boss GR, Reeder A, Bell S. (2016) Development of a Hydrogen Sulfide End-of-Service-Life Indicator for Respirator Cartridges Using Cobinamide. Sens Actuators B Chem. 230:658-666.  Abstract

Haouzi P. (2016) Is exogenous hydrogen sulfide a relevant tool to address physiological questions on hydrogen sulfide? Respir Physiol Neurobiol. [Epub ahead of print]  Abstract

Haouzi P, Sonobe T, Judenherc-Haouzi A. (2016) Developing effective countermeasures against acute hydrogen sulfide intoxication: challenges and limitations. Ann N Y Acad Sci. [Epub ahead of print]  Abstract

Judenherc-Haouzi A, Zhang XQ, Sonobe T, Song J, Rannals MD, Wang J, Tubbs N, Cheung JY, Haouzi P. (2016) Methylene Blue Counteracts H2S Toxicity Induced Cardiac Depression by Restoring L-TypeCa Channel Activity. Toxicol Appl Pharmacol. [Epub ahead of print]  Abstract

Kovacs K, Duke AC, Shifflet M, Winner B, Lee SA, Rockwood GA, Petrikovics I. (2016) Parenteral dosage form development and testing of dimethyl trisulfide, as an antidote candidate to combat cyanide intoxication. Pharm Dev Technol. [Epub ahead of print]  Abstract

Kovacs K, Jayanna PK, Duke A, Winner B, Negrito M, Angalakurthi S, Yu JC, Füredi P, Ludányi K, Sipos P, Rockwood GA, Petrikovics I. (2016) Curr Drug Deliv. [Epub ahead of print]  Abstract

Rockwood GA, Thompson DE, Petrikovics I. (2016) Dimethyl trisulfide: A novel cyanide countermeasure. Toxicol Ind Health. [Epub ahead of print]  Abstract

Szilagyi JT, Mishin V, Heck DE, Jan YH, Aleksunes LM, Richardson JR, Heindel ND, Laskin DL, Laskin JD. (2016) Selective Targeting of Heme Protein in Cytochrome P450 and Nitric Oxide Synthase by Diphenyleneiodonium. Toxicol Sci. [Epub ahead of print]  Abstract



Hauck ZZ, Feinstein DL, van Breemen RB. (2016) LC-MS-MS Analysis of Brodifacoum Isomers in Rat Tissue. J Anal Toxicol. [Epub ahead of print]  Abstract

Marangoni MN, Martynowycz MW, Kuzmenko I, Braun D, Polak PE, Weinberg G, Rubinstein I, Gidalevitz D, Feinstein DL. (2016) Membrane Cholesterol Modulates Superwarfarin Toxicity. Biophys J. 110(8): 1777-1788.  Abstract

(31 Total 2016 Publications)