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CounterACT Publications 2018

Vesicating Agents

Toxicol Lett. 2018 Mar 10. pii: S0378-4274(18)30092-4. doi: 10.1016/j.toxlet.2018.03.007. [Epub ahead of print] Abstract

Articles Highlighted in Journal Issues

Cover page: Reddy, S, Texas A & M, (2018) Journal of Pharmacology and Experimental Therapeutics, 354(1):97-109 Abstract


CounterACT Publications 2016

Neurotoxic Agents

Appu AP, Arun P, Krishnan JK, Moffett JR, Namboodiri AM. (2016) Rapid intranasal delivery of chloramphenicol acetyltransferase in the active form to different brain regions as a model for enzyme therapy in the CNS. J Neurosci Methods. 259: 129-34.  Abstract

Aroniadou-Anderjaska V, Figueiredo TH, Apland JP, Prager EM, Pidoplichko VI, Miller SL, Braga MF. (2016) Long-term neuropathological and behavioral impairments after exposure to nerve agents. Ann N Y Acad Sci. [Epub ahead of print]  Abstract

Bourne Y, Sharpless KB, Taylor P, Marchot P. (2016) Steric and dynamic parameters influencing in situ cycloadditions to form triazole inhibitors with crystalline acetylcholinesterase. J Am Chem Soc. [Epub ahead of print]  Abstract

Carver C, Reddy DS. (2016) Neurosteroid Structure-Activity Relationships for Functional Activation of Extrasynaptic delta-GABA-A Receptors. J Pharmacol Exp Ther. [Epub ahead of print]  Abstract

Chambers JE, Meek EC, Chambers HW. (2016) Novel brain-penetrating oximes for reactivation of cholinesterase inhibited by sarin and VX surrogates. Ann N Y Acad Sci. [Epub ahead of print]  Abstract

Coban A, Carr RL, Chambers HW, Willeford KO, Chambers JE. (2016) Comparison of Inhibition Kinetics of Several Organophosphates, including Some Nerve Agent Surrogates, using Human Erythrocyte and Rat and Mouse Brain Acetylcholinesterase. Toxicol Lett. [Epub ahead of print]  Abstract

Koenig JA, Dao TL, Kan RK, Shih TM. (2016) Zebrafish as a model for acetylcholinesterase-inhibiting organophosphorus agent exposure and oxime reactivation. Ann N Y Acad Sci. [Epub ahead of print]  Abstract

Krishnan JK, Arun P, Appu AP, Vijayakumar N, Figueiredo TH, Braga MF, Baskota S, Olsen CH, Farkas N, Dagata J, Frey WH 2nd, Moffett JR, Namboodiri AM. (2016) Intranasal delivery of obidoxime to the brain prevents mortality and CNS damage from organophosphate poisoning. Neurotoxicology. 53:64-73.  Abstract

Rogawski MA, Löscher W, Rho JM. (2016) Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet. Cold Spring Harb Perspect Med. [Epub ahead of print]  Abstract

Wright LK, Lee RB, Vincelli NM, Whalley CE, Lumley LA. (2016) Comparison of the lethal effects of chemical warfare nerve agents across multiple ages. Toxicol Lett. 241:167-74.  Abstract


Vesicating Agents

Das LM, Binko AM, Traylor ZP, Duesler LR, Dynda SM, Debanne S, Lu KQ. (2016) Early indicators of survival following exposure to mustard gas: protective role of 25(OH)D. Toxicol Lett. [Epub ahead of print]  Abstract

DeSantis-Rodrigues A, Chang YC, A Hahn R, P Po I, Zhou P, Lacey CJ, Pillai A, C Young S, A Flowers Ii R, A Gallo M, D Laskin J, R Gerecke D, K H Svoboda K, D Heindel N, Gordon MK. (2016) ADAM17 Inhibitors Attenuate Corneal Epithelial Detachment Induced by Mustard Exposure. Invest Ophthalmol Vis Sci. 57(4):1687-98.  Abstract

Tewari-Singh N, Croutch CR, Tuttle R, Goswami DG, Kant R, Peters E, Culley T, Ammar DA, Enzenauer RW, Petrash JM, Casillas RP, Agarwal R. (2016) Clinical progression of ocular injury following arsenical vesicant lewisite exposure. Cutan Ocul Toxicol. [Epub ahead of print]  Abstract

Wohlman IM, Composto GM, Heck DE, Heindel ND, Lacey CJ, Guillon CD, Casillas RP, Croutch CR, Gerecke DR, Laskin DL, Joseph LB, Laskin JD. (2016) Mustard vesicants alter expression of the endocannabinoid system in mouse skin. Toxicol Appl Pharmacol. [Epub ahead of print]  Abstract


Pulmonary Agents

Conklin DJ. (2016) Acute cardiopulmonary toxicity of inhaled aldehydes: role of TRPA1. Ann N Y Acad Sci. [Epub ahead of print]  Abstract

Hoyle GW, Chen J, Schlueter CF, Mo Y, Humphrey DM Jr, Rawson G, Niño JA, Carson KH. (2016) Development and assessment of countermeasure formulations for treatment of lung injury induced by chlorine inhalation. Toxicol Appl Pharmacol. [Epub ahead of print]  Abstract

Jiang J, Chan A, Ali S, Saha A, Haushalter KJ, Lam WM, Glasheen M, Parker J, Brenner M, Mahon SB, Patel HH, Ambasudhan R, Lipton SA, Pilz RB, Boss GR. (2016) Hydrogen Sulfide-Mechanisms of Toxicity and Development of an Antidote. Sci Rep. [Epub ahead of print]  Abstract

Parseghian MH, Hobson ST, Richieri RA. (2016) Targeted heat shock protein 72 for pulmonary cytoprotection. Ann N Y Acad Sci. [Epub ahead of print]  Abstract

Perkins MW, Wong B, Tressler J, Coggins A, Rodriguez A, Devorak J, Sciuto AM. (2016) Assessment of inhaled acute ammonia-induced lung injury in rats. Inhalation Toxicology. [Epub ahead of print]  Abstract  


Metabolic/Cellular Poisons

Bartling CM, Andre JC, Howland CA, Hester ME, Cafmeyer JT, Kerr A, Petrel T, Petrikovics I, Rockwood GA. (2016) Stability Characterization of a Polysorbate 80-Dimethyl Trisulfide Formulation, a Cyanide Antidote Candidate. Drugs R D. [Epub ahead of print]  Abstract

Benz OS, Yuan Q, Cronican A, Peterson J, Pearce LL. (2016) The Effect of Ascorbate on the Cyanide Scavenging Capability of cobalt(III) meso-tetra(4-N-methylpyridyl)porphine triiodide: Deactivation by Reduction? Chem Res Toxicol. [Epub ahead of print]  Abstract

Greenawald LA, Boss GR, Reeder A, Bell S. (2016) Development of a Hydrogen Sulfide End-of-Service-Life Indicator for Respirator Cartridges Using Cobinamide. Sens Actuators B Chem. 230:658-666.  Abstract

Haouzi P. (2016) Is exogenous hydrogen sulfide a relevant tool to address physiological questions on hydrogen sulfide? Respir Physiol Neurobiol. [Epub ahead of print]  Abstract

Haouzi P, Sonobe T, Judenherc-Haouzi A. (2016) Developing effective countermeasures against acute hydrogen sulfide intoxication: challenges and limitations. Ann N Y Acad Sci. [Epub ahead of print]  Abstract

Judenherc-Haouzi A, Zhang XQ, Sonobe T, Song J, Rannals MD, Wang J, Tubbs N, Cheung JY, Haouzi P. (2016) Methylene Blue Counteracts H2S Toxicity Induced Cardiac Depression by Restoring L-TypeCa Channel Activity. Toxicol Appl Pharmacol. [Epub ahead of print]  Abstract

Kovacs K, Duke AC, Shifflet M, Winner B, Lee SA, Rockwood GA, Petrikovics I. (2016) Parenteral dosage form development and testing of dimethyl trisulfide, as an antidote candidate to combat cyanide intoxication. Pharm Dev Technol. [Epub ahead of print]  Abstract

Kovacs K, Jayanna PK, Duke A, Winner B, Negrito M, Angalakurthi S, Yu JC, Füredi P, Ludányi K, Sipos P, Rockwood GA, Petrikovics I. (2016) Curr Drug Deliv. [Epub ahead of print]  Abstract

Rockwood GA, Thompson DE, Petrikovics I. (2016) Dimethyl trisulfide: A novel cyanide countermeasure. Toxicol Ind Health. [Epub ahead of print]  Abstract

Szilagyi JT, Mishin V, Heck DE, Jan YH, Aleksunes LM, Richardson JR, Heindel ND, Laskin DL, Laskin JD. (2016) Selective Targeting of Heme Protein in Cytochrome P450 and Nitric Oxide Synthase by Diphenyleneiodonium. Toxicol Sci. [Epub ahead of print]  Abstract



Hauck ZZ, Feinstein DL, van Breemen RB. (2016) LC-MS-MS Analysis of Brodifacoum Isomers in Rat Tissue. J Anal Toxicol. [Epub ahead of print]  Abstract

Marangoni MN, Martynowycz MW, Kuzmenko I, Braun D, Polak PE, Weinberg G, Rubinstein I, Gidalevitz D, Feinstein DL. (2016) Membrane Cholesterol Modulates Superwarfarin Toxicity. Biophys J. 110(8): 1777-1788.  Abstract

(31 Total 2016 Publications)


CounterACT Publications 2015

Neurotoxic Agents

Ben-David M, Sussman JL, Maxwell CI, Szeler K, Kamerlin SC, Tawfik DS. (2015) Catalytic stimulation by restrained active-site floppiness - the case of high-density lipoprotein bound serum paraoxonase-1. J Mol Biol. 427(6 Pt B):1359-74.  Abstract

Blair RE, Desphande LS, DeLorenzo RJ. (2015) Cannabinoids: Is there a potential treatment role in epilepsy? Expert Opin Pharmacother. 16(13): 1911-4.  Abstract

Bruun DA, Cao Z, Inceoglu B, Vito ST, Austin AT, Hulsizer S, Hammock BD, Tancredi DJ, Rogawski MA, Pessah IN, Lein PJ. (2015) Combined treatment with diazepam and allopregnanolone reverses Tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures. Neuropharmacology. 95:332-42.  Abstract

Cao Z, Zou X, Cui Y, Hulsizer SC, Lein PJ, Wulff H, Pessah IN. (2015) Rapid Throughput Analysis Demonstrates that Chemicals with Distinct Seizurogenic Mechanisms Differentially Alter Ca2+ Dynamics in Networks Formed by Hippocampal Neurons in Culture. Mol Pharmacol. 87(4):595-605.  Abstract

Chambers JE, Meek EC, Bennett JP, Bennett WS, Chambers HW, Leach CA, Pringle RB, Wills RW. (2015) Novel substituted phenoxyalkyl pyridinium oximes enhance survival and attenuate seizure-like behavior of rats receiving lethal levels of nerve agent surrogates. Toxicology. 339: 51-57.  Abstract

DeArmond PD, Brittain MK, Platoff GE Jr, Yeung DT. (2015) QuEChERS-based approach toward the analysis of two insecticides, methomyl and aldicarb, in blood and brain tissue. Anal Methods. 7(1):321-328. Abstract 

Desai R, Savechenkov PY, Zolkowska D, Ge RL, Rogawski MA, Bruzik KS, Forman SA, Raines DE, Miller KW. (2015) Contrasting actions of a convulsant barbiturate and its anti-convulsant enantiomer on the α1β3γ2L GABAA receptor account for their in vivo effects. J Physiol. 593(22):  4943-61.  Abstract

Ferchmin PA, Pérez D, Cuadrado BL, Carrasco M, Martins AH, Eterović VA. (2015) Neuroprotection against Diisopropylfluorophosphate in acute hippocampal slices. Neurochem Res. 40(10): 2143-51.  Abstract

Fu Y, Yang MS, Jiang J, Ganesh T, Joe E, Dingledine R. (2015). EP2 receptor signaling regulates microglia death. Mol Pharmacol. 2015 Jul;88(1):161-70. Abstract

Golub VM, Brewer J, Wu X, Kuruba R, Short J, Manchi M, Swonke M, Younus I, Redd DS. (2015) Neurostereology protocol for unbiased quantification of neuronal injury and neurodegeneration. Front Aging Neurosci. 7:196.  Abstract

Jan YH, Richardson JR, Baker AA, Mishin V, Heck DE, Laskin DL, Laskin JD. (2015) Vitamin K3 (menadione) redox cycling inhibits cytochrome P450-mediated metabolism and inhibits parathion intoxication. Toxicol Appl Pharmacol. 288(1): 114-20.  Abstract

Katz FS, Pecic S, Tran TH, Trakht I, Schneider L, Zhu Z, Ton-That L, Luzac M, Zlatanic V, Damera S, Macdonald J, Landry DW, Tong L, Stojanovic MN. (2015) Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates. Chembiochem.  16(15):2205-15.  Abstract

Kovarik Z, Macek Hrvat N, Katalinic M, Sit RK, Paradyse A, Zunec S, Musilek K, Fokin VV, Taylor P, Radic Z. (2015) Catalytic soman scavenging by Y337A/F338A acetylcholinesterase mutant assisted with novel site-directed aldoximes. Chem Res Toxicol. 28(5):1036-44.  Abstract

Li Y, Lein PJ, Ford GD, Liu C, Stovall KC, White TE, Bruun DA, Tewolde T, Gates AS, Distel TJ, Surles-Zeigler MC, Ford BD. (2015) Neuregulin-1 inhibits neuroinflammatory responses in a rat model of organophosphate-nerve agent-induced delayed neuronal injury. J Neuroinflammation. 2015 Apr 2;12(1):64.  Abstract

Mangas I, Taylor P, Vilanova E, Estévez J, França TC, Komives E, Radić Z. (2015) Resolving pathways of interaction of mipafox and a sarin analog with human acetylcholinesterase by kinetics, mass spectrometry and molecular modeling approaches. Arch Toxicol. [Epub ahead of print]  Abstract

Miller SL, Aroniadou-Anderjaska V, Figueiredo TH, Prager EM, Almeida-Suhett CP, Apland JP, Braga MF. (2015) A rat model of nerve agent exposure applicable to the pediatric population: The anticonvulsant efficacies of atropine and GluK1 antagonists. Toxicol Appl Pharmacol. 284(2):204-16.  Abstract

Niquet J, Baldwin R, Gezalian M, Wasterlain CG. (2015) Deep hypothermia for the treatment of refractory status epilepticus. Epilepsy Behav. 49:313-7. Abstract 

Niquet J, Gezalian M, Baldwin R, Wasterlain CG. (2015) Neuroprotective effects of deep hypothermia in refractory status epilepticus. Ann Clin Transl Neurol. 2(12): 1105-15. Abstract

Obiorah M, McCandlish E, Buckley B, DiCicco-Bloom E. (2015) Hippocampal developmental vulnerability to methylmercury extends into prepubescence. Front Neurosci. 9:150.  Abstract

Prager EM, Bergstrom HC, Wynn GH, Braga MF. (2015) The basolateral amygdala γ-aminobutyric acidergic system in health and disease. J Neurosci Res. [Epub ahead of Print]  Abstract

Reddy SD, Younus I, Clossen B, Reddy DS. (2015) Antiseizure Activity of Midazolam in Mice Lacking delta-Subunit Extrasynaptic GABA-A Receptors. J Pharmacol Exp Ther. 353(3):517-28.  Abstract

Reddy SD, Reddy DS. (2015) Midazolam as an anticonvulsant antidote for organophosphate intoxication-A pharmacotherapeutic appraisal. Epilepsia. 56(6):813-21.  Abstract

Rogawski MA, Tofighy A, White HS, Matagne A, Wolff C. (2015) Current understanding of the mechanism of action of the antiepileptic drug lacosamide. Epilepsy Res. 110:189-205.  Abstract

Rojas A, Ganesh T, Lelutiu N, Gueorguieva P, Dingledine R. (2015) Inhibition of the prostaglandin EP2 receptor is neuroprotective and accelerates functional recovery in a rat model of organophosphorus induced status epilepticus. Neuropharmacology. 2015 Jun;93:15-27. Abstract 

Rosenberg YJ, Adams RJ, Abanto SH, Jiang X, Sun W, Mao L, Lee KD. (2015) Pharmacokinetics and immunogenicity of a recombinant human butyrylcholinesterase bioscavenger in macaques following intravenous and pulmonary delivery. Chem Biol Interact. 242:219-226.  Abstract

Rowley S, Liang LP, Fulton R, Shimizu T, Day B, Patel M. (2015) Mitochondrial Respiration Deficits Driven by Reactive Oxygen Species in Experimental Temporal Lobe Epilepsy. Neurobiol Dis. 75:151-8. Abstract

Ruiz CA, Rossi SG, Rotundo RL. (2015) Rescue and Stabilization of Acetylcholinesterase in Skeletal Muscle by N-Terminal Peptides Derived from the Non-Catalytic Subunits. J Biol Chem. 290(34):20774-81. Abstract

Schmidt HR, Radić Z, Taylor P, Fradinger EA. (2015) Quaternary and tertiary aldoxime antidotes for organophosphate exposure in a zebrafish model system. Toxicol Appl Pharmacol. 284(2):197-203. Abstract

Shakarjian MP, Ali MS, Velíšková J, Stanton PK, Heck DE, Velíšek L. (2015) Combined Diazepam and MK-801 Therapy Provides Synergistic Protection from Tetramethylenedisulfotetramine-induced Tonic-Clonic Seizures and Lethality in Mice. Neurotoxicology. 48:100-8.  Abstract

Smith CD, Wright LK, Garcia GE, Lee RB, Lumley LA. (2015) Hormone-dependence of sarin lethality in rats: sex differences and stage of the estrous cycle. Toxicol Appl Pharmacol. 287(3):253-7.  Abstract

Snider TH, Wilhelm CM, Babin MC, Platoff GE Jr, Yeung DT. (2015) Assessing the therapeutic efficacy of oxime therapies against percutaneous organophosphorus pesticide and nerve agent challenges in the Hartley guinea pig. J Toxicol Sci. 40(6):759-75.  Abstract

Suchomelova L, Lopez-Meraz ML, Niquet J, Kubova H, Wasterlain CG. (2015) Hyperthermia aggravates status epilepticus-induced epileptogenesis and neuronal loss in immature rats. Neuroscience. 305:209-24.  Abstract

Torolira D, Suchomelova L, Wasterlain CG, Niquet J. (2015) Widespread neuronal injury in a model of cholinergic status epilepticus in postnatal day 7 rat pups. Epilepsy Res. 120: 47-54.  Abstract

Varvel NH, Jiang J, Dingledine R. (2015) Candidate drug targets for prevention or modification of epilepsy. Annu Rev Pharmacol Toxicol. 2015;55:229-47. Abstract 

Vélez-Carrasco W, Green CE, Catz P, Furimsky A, O'Loughlin K, Eterović VA, Ferchmin PA. (2015) Pharmacokinetics and Metabolism of 4R-Cembranoid. PLoS One. 2015 Mar 26;10(3)  Abstract

Vezzani A, Dingledine R, Rossetti AO. (2015) Immunity and inflammation in status epilepticus and its sequelae: possibilities for therapeutic application. Expert Rev Neurother. 15(9):1081-92.  Abstract


Vesicating Agents

Au L, Meisch JP, Das LM, Binko AM, Boxer RS, Wen AM, Steinmetz NF, Lu KQ. (2015) Suppression of Hyperactive Immune Responses Protects against Nitrogen Mustard Injury. J Invest Dermatol. 135(12): 2971-81.  Abstract

Goswami DG, Tewari-Singh N, Dhar D, Kumar D, Agarwal C, Ammar DA, Kant R, Enzenauer RW, Petrash JM, Agarwal R. (2015) Nitrogen mustard-induced corneal injury involves DNA damage and pathways related to inflammation, epithelial-stromal separation, and neovascularization. Cornea. 35(2): 257-66.  Abstract

Jain AK, Tewari-Singh N, Inturi S, Kumar D, Orlicky DJ, Agarwal C, White CW, Agarwal R. (2015) Flavanone silibinin treatment attenuates nitrogen mustard-induced toxic effects in mouse skin. Toxicol Appl Pharmacol. 285(1):71-8.  Abstract

Jan YH, Heck DE, Casillas RP, Laskin DL, Laskin JD. (2015) Thioredoxin cross-linking by nitrogen mustard in lung epithelial cells: formation of multimeric thioredoxin/thioredoxin reductase complexes and inhibition of disulfide reduction. Chem Res Toxicol. 28(11): 2091-103.  Abstract

Kumar D, Tewari-Singh N, Agarwal C, Jain AK, Inturi S, Kant R, White CW, Agarwal R. (2015) Nitrogen mustard exposure of murine skin induces DNA damage, oxidative stress and activation of MAPK/Akt-AP1 pathway leading to induction of inflammatory and proteolytic mediators. Toxicol Lett. 235(3):161-71.  Abstract

Malaviya R, Gow AJ, Francis M, Abramova EV, Laskin JD, Laskin DL. (2015) Radiation-induced lung injury and inflammation in mice: role of inducible nitric oxide synthase and surfactant protein D. Toxicol Sci. 144(1): 27-38.  Abstract

Malaviya R, Sunil VR, Venosa A, Vayas KN, Heck DE, Laskin JD, Laskin DL. (2015) Inflammatory mechanisms of pulmonary injury induced by mustards. Toxicol Lett. [Epub ahead of Print]  Abstract

Plahovinsak JL, Buccellato MA, Reid FM, Graham JS. (2015) Selection of non-steroidal anti-inflammatory drug and treatment regimen for sulfur mustard-induced cutaneous lesions. Cutan Ocul Toxicol. 11:1-10.  Abstract

Saxena J, Meloni D, Huang MT, Heck DE, Laskin JD, Heindel ND, Young SC. (2015) Ethynylphenyl carbonates and carbamates as dual-action acetylcholinesterase inhibitors and anti-inflammatory agents. Bioorg Med Chem Lett. 25(23): 5609-12.  Abstract

Son Y, Mishin V, Welsh W, Lu SE, Laskin JD, Kipen H, Meng Q. (2015) A Novel High-Throughput Approach to Measure Hydroxyl Radicals Induced by Airborne Particulate Matter. Int J Environ Res Public Health. 12(11):13678-95.  Abstract

Spitler R, Ho H, Norpetlian F, Kong X, Jiang J, Yokomori K, Andersen B, Boss GR, Berns MW. (2015) Combination of low level light therapy and nitrosyl-cobinamide accelerates wound healing. J Biomed Opt. 20(5):051022.  Abstract

Udasin RG, Wen X, Bircsak KM, Aleksunes LM, Shakarjian MP, Kong AT, Heck DE, Laskin DL, Laskin JD. (2015) Nrf2 regulates the sensitivity of mouse keratinocytes to nitrogen mustard via multidrug resistance-associated protein 1 (Mrp1). Toxicol Sci. 149(1): 202-12.  Abstract

Venosa A, Malaviya R, Choi H, Gow AJ, Laskin JD, Laskin DL. (2015) Characterization of Distinct Macrophage Subpopulations During Nitrogen Mustard-Induced Injury and Fibrosis. Am J Respir Cell Mol Biol. [Epub ahead of print]  Abstract


Pulmonary Agents

Aggarwal S, Lam A, Bolisetty S, Carlisle MA, Traylor A, Agarwal A, Matalon S. (2015) Heme attenuation ameliorates irritant gas inhalation induced acute lung injury. Antioxid Redox Signal. 24(2): 99-112. Abstract

Holmes WW, Keyser BM, Paradiso DC, Ray R, Andres DK, Benton BJ, Rothwell CC, Hoard-Fruchey HM, Dillman JF, Sciuto AM, Anderson DR. (2015) Conceptual approaches for treatment of phosgene inhalation-induced lung injury. Toxicol Lett. [Epub ahead of Print]  Abstract

Jurkuvenaite A, Benavides GA, Komarova S, Doran SF, Johnson M, Aggarwal S, Zhang J, Darley-Usmar VM, Matalon S. (2015) Upregulation of autophagy Decreases chlorine gas induced Mitochondrial Injury and Lung Inflammation. Free Radic Biol Med. 85:83-94.  Abstract

Lazrak A, Creighton JR, Yu Z, Komarova S, Doran SF, Aggarwal S, Emala CW Sr, Stober VP, Trempus CS, Garantziotis S, Matalon S. (2015) Hyaluronan mediates airway hyper-responsiveness in oxidative lung injury. Am J Physiol Lung Cell Mol Physiol. 308(9):L891-903.  Abstract

Londino JD, Lazrak A, Noah JW, Aggarwal S, Bali V, Woodworth BA, Bebok Z, Matalon S. (2015) Influenza virus M2 targets cystic fibrosis transmembrane conductance regulator for lysosomal degradation during viral infection. FASEB J. 29(7):2712-25.  Abstract

Matalon S, Bartoszewski R, Collawn JF. (2015) Role of Epithelial Sodium Channels (ENaC) In the Regulation of Lung Fluid Homeostasis. Am J Physiol Lung Cell Mol Physiol. 309(11):L1229-38.  Abstract

McElroy C, Day BJ. (2015) Antioxidants as Potential Medical Countermeasures for Chemical Warfare Agents and Toxic Industrial Chemicals. Biochem Pharmacol. [Epub ahead of Print]  Abstract

Plahovinsak JL, Perry MR, Knostman KA, Segal R, Babin MC. (2015) Characterization of a nose-only inhaled phosgene acute lung injury mouse model. Inhal Toxicol. 27(14): 832-840.  Abstract

Song W, Yu Z, Doran SF, Ambalavanan N, Steele C, Garantziotis S, Matalon S. (2015) Respiratory Syncytial Virus Infection Increases Chlorine Induced Airway Hyper-responsiveness. Am J Physiol Lung Cell Mol Physiol. 309(3):L205-10.  Abstract

Sunil VR, Francis M, Vayas KN, Cervelli JA, Choi H, Laskin JD, Laskin DL. (2015) Regulation of ozone-induced lung inflammation and injury by the β-galactoside-binding lectin galectin-3. Toxicol Appl Pharmacol. 284(2):236-45.  Abstract

Surolia R, Karki S, Kim H, Yu Z, Kulkarni T, Mirov SB, Carter AB, Rowe SM, Matalon S, Thannickal VJ, Agarwal A, Antony VB. (2015) Heme oxygenase-1-mediated autophagy protects against pulmonary endothelial cell death and development of emphysema in cadmium-treated mice. Am J Physiol Lung Cell Mol Physiol. 309(3):L280-92.  Abstract

Zaky A, Bradley WE, Lazrak A, Zafar I, Doran S, Ahmad A, White CW, Dell'Italia LJ, Matalon S, Ahmad S. (2015) Chlorine inhalation-induced myocardial depression and failure. Physiol Rep. [Epub ahead of print] Abstract

Venosa A, Malaviya R, Gow AJ, Hall L, Laskin JD, Laskin DL. (2015) Protective Role of Spleen-Derived Macrophages in Lung Inflammation, Injury and Fibrosis Induced by Nitrogen Mustard. Am J Physiol Lung Cell Mol Physiol. 309(12):L1487-98. Abstract

Zaky A, Ahmad A, Dell'Italia LJ, Jahromi L, Reisenberg LA, Matalon S, Ahmad S. (2015) Inhaled matters of the heart. Cardiovasc Regen Med. [Epub ahead of Print]  Abstract


Metabolic/Cellular Poisons

Chan A, Jiang J, Fridman A, Guo LT, Shelton GD, Liu M, Green C, Haushalter KJ, Patel HH, Lee J, Yoon D, Burney T, Mukai D, Mahon SB, Brenner M, Pilz RB, Boss GR. (2015) Nitrocobinamide, a New Cyanide Antidote that can be Administered by Intramuscular Injection. J Med Chem. 58(4):1750-9.  Abstract

Chenuel B, Sonobe T, Haouzi P. (2015) Effects of infusion of human methemoglobin solution following hydrogen sulfide poisoning. Clin Toxicol (Phila). 53(2):93-101  Abstract

Cronican AA, Frawley KL, Ahmed H, Pearce LL, Peterson J. (2015) Antagonism of Acute Sulfide Poisoning in Mice by Nitrite Anion without Methemoglobinemia. Chem Res Toxicol. 28(7):1398-408.  Abstract

Haouzi P, Chenuel B, Sonobe T. (2015) High-dose hydroxocobalamin administered after H2S exposure counteracts sulfide-poisoning-induced cardiac depression in sheep. Clin Toxicol (Phila). 53(1):28-36.  Abstract

Haouzi P, Sonobe T. (2015) Cardiogenic shock induced reduction in cellular O2 delivery as a hallmark of acute H2S intoxication. Clin Toxicol (Phila). 53(4):416-7.  Abstract

McCracken BA, Brittain MK. (2015) High performance liquid chromatography tandem mass spectrometryassay for the determination of cobinamide in pig plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 1006: 104-11. Abstract

Sonobe T, Chenuel B, Cooper TK, Haouzi P. (2015) Immediate and Long-Term Outcome of Acute H2S Intoxication Induced Coma in Unanesthetized Rats: Effects of Methylene Blue.PLoS One. Abstract

Sonobe T, Haouzi P. (2015) H2S induced coma and cardiogenic shock in the rat: Effects of phenothiazinium chromophores. Clin Toxicol (Phila). 53(6):525-39.  Abstract

Stutelberg MW, Dzisam JK, Monteil AR, Petrikovics I, Boss GR, Patterson SE, Rockwood GA, Logue BA. (2015) Simultaneous determination of 3-mercaptopyruvate and cobinamide in plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 1008: 181-188. Abstract

Zhang D, Lee B, Nutter A, Song P, Dolatabadi N, Parker J, Sanz-Blasco S, Newmeyer T, Ambasudhan R, McKercher SR, Masliah E, Lipton SA. (2015) Protection from cyanide-induced brain injury by the Nrf2 transcriptional activator carnosic acid. J Neurochem. 133(6):898-908. Abstract



Fettiplace MR, Lis K, Ripper R, Kowal K, Pichurko A, Vitello D, Rubinstein I, Schwartz D, Akpa BS, Weinberg G (2105). Multi-modal contributions to detoxification of acute pharmacotoxicity by a triglyceride micro-emulsion. J Control Release. 198:62-70.  Abstract

Ware KM, Feinstein DL, Rubinstein I, Weinberg G, Rovin BH, Hebert L, Muni N, Cianciolo RE, Satoskar AA, Nadasdy T, Brodsky SV. (2015) Brodifacoum Induces Early Hemoglobinuria and Late Hematuria in Rats: Novel Rapid Biomarkers of Poisoning. Am J Nephrol. 2015;41(4-5):392-9. Abstract

(76 Total 2015 Publications)