NINDS supports research on traumatic brain injury (TBI) to advance knowledge on mechanisms of injury and recovery, and to develop better diagnostic tools and more effective treatments. This website provides information on NINDS activities, opportunities and resources for TBI research.
Clinical Research and TBI
Recent NINDS-sponsored clinical research in TBI include:
- Transforming Research and Clinical Knowledge in TBI - TRACK TBI
- Multiple Medical Therapies for Pediatric TBI; Comparative Effectiveness Approach – ADAPT TRIAL
- Erythropoietin on Cerebral Vascular Dysfunction in Human TBI
- Brain Tissue Oxygen Monitoring
Translational Research and TBI
NINDS Translational Program focuses on preclinical development and testing of novel therapeutics and devices. Examples of TBI projects funded under this cooperative program include:
- Preclinical Cyclosporine A Therapy Trials for Pediatric TBI
- Cell Based Therapy for Treatment of TBI
- Polynitroxylated Pegylated Hemoglobin for TBI Resuscitation
- An Erythropoietin-Mimetic Peptide for Treatment of TBI
Specific TBI Research Programs:
The Sports and Health Research Program (SHRP) is a public-private partnership of the National Institutes of Health (NIH), the Foundation for the NIH (FNIH) and the National Football League (NFL), aimed at addressing major public health issues related to sports participation.
- NINDS Director’s Statement on CTE Research
- Sports and Health Research Program Stakeholders meet to discuss sports-related brain injury research
Tools & Resources
Common Data Elements
NINDS CDEs for TBI
NIH RePORTER, an online reporting tool, allows users to search a repository of NIH-funded TBI research projects and access publications and patents resulting from NIH funding.
Dr. Geoffrey Manley
University of California San Francisco
Dr. Geoffrey Manley of the University of California San Francisco discusses the value of TBI data sharing and comparative effective research in his TRACK-TBI initiative.
The Neurological Emergencies Treatment Trials (NETT) Network engages clinicians and providers at the front lines of emergency care to conduct multicenter clinical trials focused on improving outcomes in patients with TBI and acute neurological injuries.
The FITBIR Informatics System is a platform, developed by the NIH and the Department of Defense, which allows data sharing across the entire TBI community. Sharing data, associated tools and methodologies accelerates research progress by allowing re-analysis of data, as well as re-aggregation, integration and rigorous comparison with other data, tools and methods.
The International Initiative for Traumatic Brain Injury Research (InTBIR) is a collaborative effort of the NIH, the European Commission and the Canadian Institutes of Health to advance clinical TBI research, treatment and care.
- Traumatic Brain Injury - An International Knowledge-Based Approach
- Toward an International Initiative for Traumatic Brain Injury Research
Meetings & Workshops
- Report from the First NIH Consensus Conference to Define the Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy February, 2015
- InTBIR 3rd Conference 2014 [pdf, 297 kb] Participant List