Focus on Epilepsy Research

The epilepsies are a set of disorders characterized by recurring seizures, or disturbances in the electrical activity of the brain. Epilepsy affects people of all ages, from infants to the aged, and can result from many causes, including genetic variations, illness, head injury, or abnormal brain development. NIH/NINDS and its community-based research partners are dedicated to finding cures for the epilepsies and/or preventing epilepsy in individuals at risk for seizures.

 

NINDS Epilepsy Research Initiatives

The NINDS established the Centers Without Walls program in 2010 to rapidly advance epilepsy research through promoting interdisciplinary, collaborative research. Three centers have been funded:

  • The Epilepsy 4000 (Epi4K) collaborative has examined genetic data from 4,000 individuals in order to understand the genes underlying epilepsy. See an NIH news release about the center.
  • The Center for SUDEP Research (CSR) brings together extensive expertise to understand Sudden Unexplained Death in Epilepsy. See an NIH news release about the center.
  • The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBiosS4Rx) will use studies of animals and patients with traumatic brain injury (TBI) leading to post-traumatic epilepsy (PTE) in order to develop future clinical trials of epilepsy prevention therapies.

NIH Epilepsy Funding

Funding information tools:


Planning Efforts

Benchmarks for Epilepsy Research


Tools & Resources

PANAChE Database - This resource contains public and non-confidential chemical structures and biological data for compounds which have been screened for efficacy and toxicity in animal models of epilepsy and related seizure disorders as part of the Epilepsy Therapy Screening Program (ETSP) at the National Institute of Neurological Disorders and Stroke. 

Epilepsy Therapy Screening Program (ETSP) - This resource contains public and non-confidential chemical structures and biological data for compounds which have been screened for efficacy and toxicity in animal models of epilepsy and related seizure disorders as part of the Epilepsy Therapy Screening Program (ETSP) at the National Institute of Neurological Disorders and Stroke. 

Epilepsy Common Data Elements - The NINDS epilepsy common data elements provide data standards for clinical research in order to improve data quality and facilitate comparison and combination of data across studies.

ICARE: Interagency Collaborative to Advance Research in Epilepsy - ICARE provides an interagency forum for sharing information about ongoing and planned epilepsy research activities.

Resources in Epilepsy Research - This is a set of resources by the American Epilepsy Society to facilitate basic epilepsy research.

The Epilepsy Research Connection (ERC) - The ERC provides information about grant and funding opportunities from non-profit and government organizations focused on epilepsy related research.

Epilepsy Organizations


Meetings & Workshops

The Society for Neuroscience (SfN) 2017, November 11 – November 15, 2017

The American Epilepsy Society Annual Meeting 2017, December 1 – December 5, 2017

International Conference on Epilepsy and Treatment, Monday, September 21, 2015

31st International Epilepsy Congress, Saturday, September 5, 2015

Epilepsy Across the Spectrum: Promoting Health and Understanding (IOM, March 2012)

Workshop Summaries and Related Publications

Curing the Epilepsies: The Promise of Research

Archived Publications